Potential of Bacillus subtilis Against SARS-CoV-2 – A Sustainable Drug Development PerspectiveMicrobiology Published on 2022-02-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Bacillus subitilis activity Against anti-inflammatory activity Antiviral B. subtilis Bacillus Bacillus subtilis Bacteria biosurfactant Characteristics clinical trial COVID-19 COVID-19 pandemic cytokine development drug Drug development Healthcare systems hidden highest Hypothesis IL-1 β Impact in vivo monocyte neutrophil non-toxic Potential resources SARS-CoV-2 secreted surfactin triggered unique [DOI] 10.3389/fmicb.2022.718786 PMC 바로가기 [Article Type] Microbiology
Expression of SARS-CoV-2 Spike Protein Receptor Binding Domain on Recombinant B. subtilis on Spore Surface: A Potential COVID-19 Oral Vaccine CandidateArticle Published on 2021-12-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Acidic Adenovirus administration approved B. subtilis Bacillus subtilis candidate clinical development Course COVID-19 COVID-19 pandemic dormant expressing expression gastrointestinal tract gram-positive bacterium Health healthy Host inactivated increases in injection intestine mice mRNA neutralizing antibody oral Oral vaccine Pilot test Potential Prevent Receptor binding domain recombinant recombinant proteins Safe SARS-CoV-2 SARS-COV-2 infection Side effect Significant spike Spike protein spore spores sporulation temperature the SARS-CoV-2 Vaccines virus Volunteer volunteers [DOI] 10.3390/vaccines10010002 PMC 바로가기 [Article Type] Article
Polyethylene Films Containing Plant Extracts in the Polymer Matrix as Antibacterial and Antiviral MaterialsArticle Published on 2021-12-142022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] Φ6 phage active against active films active foils addition affected Analysis Antibacterial antibacterial properties antiviral activity Antiviral effect antiviral properties Bacillus subtilis Bacterial CO2 extracts Containing determine Escherichia coli exhibited Extract Features film functional Gram-negative bacteria growth indicated inhibit inhibited initial material matrix not affect offer parameter Particles PE films physicochemical plant plant extracts plants polyethylene Polymer polymer matrix pomegranate seeds Pseudomona Radiation raspberry seeds Research rosemary SARS-Co-V2 SARS-CoV-2 particles selected significantly Staphylococcus aureus strain [DOI] 10.3390/ijms222413438 PMC 바로가기 [Article Type] Article
Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro일본 발효 대두 음식 인 Natto 추출물은 시험 관내 SARS-COV-2를 포함한 바이러스 감염을 직접 억제합니다.Article Published on 2021-09-172022-08-31 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Antiviral effect Bacillus Bacillus subtilis BHV-1 binding bovine caused Cell cells coronavirus domain Evidence examined glycoprotein Glycoprotein D Health heat inactivation impair in vitro incubated infect Infection inhibit inhibited Japanese N501Y Natto nutritious Point mutation protease proteolysis RBD RBD protein Receptor binding domain respiratory restored SARS-CoV-2 Serine serine protease inhibitor severe acute respiratory syndrome Coronavirus shown the cells treated variant Viral viral infection Viral proteins viruses western blot Western blot analysis [DOI] 10.1016/j.bbrc.2021.07.034 PMC 바로가기 [Article Type] Article
Phytoconstituents, In Vitro Anti-Infective Activity of Buddleja indica Lam., and In Silico Evaluation of its SARS-CoV-2 Inhibitory PotentialPharmacology Published on 2021-04-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Buddleia indica 3CL pro active site active sites activity antimicrobial Antiviral antiviral activity Bacillus subtilis Buddleja caffeic acid comparable Compound consolidation COVID-19 COVID-19 pandemic dihydrofolate dose exhibited glucoside Helicobacter pylori herpes simplex highest HSV-1 Isolation kaempferol methanol molecular docking Molecular modeling notable phytochemical Phytoconstituents Potential Pro quercetin Safe SARS-CoV-2 Scrophulariaceae susceptible vesicular stomatitis viral replication virus VSV [DOI] 10.3389/fphar.2021.619373 PMC 바로가기 [Article Type] Pharmacology
A Multifunctional Peptide From Bacillus Fermented Soybean for Effective Inhibition of SARS-CoV-2 S1 Receptor Binding Domain and Modulation of Toll Like Receptor 4: A Molecular Docking StudyMolecular Biosciences Published on 2021-03-312022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Bacillus spp. 6M0J Accessibility ACE2 Amino acid analyzed Antiviral antiviral activity Antiviral agents antiviral peptides Asian Bacillus Bacillus subtilis binding binding interaction cell receptor Combination complex Contact contributed coronavirus 2 country COVID-19 Critical Cytokine storm differentiation docked complex fermented soybean Generalized glycoprotein human Angiotensin-converting enzyme immunomodulation in silico India inhibition Interaction interactions investigated Like modulation molecular docking motif PDB peptide Prophylaxis Protein proteome RBD receptor residue respiratory SARS-CoV-2 SARS-CoV-2 S1 screened selected soybean spike strain the receptor-binding domain the S1 protein TLR4 TLR4/MD2 complex Viral diseases ZDOCK [DOI] 10.3389/fmolb.2021.636647 PMC 바로가기 [Article Type] Molecular Biosciences
Airborne Disinfection by Dry Fogging Efficiently Inactivates Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Mycobacteria, and Bacterial Spores and Shows Limitations of Commercial Spore CarriersEnvironmental Microbiology Published on 2020-11-062022-10-28 Journal: Applied and Environmental Microbiology [Category] COVID-19, [키워드] Geobacillus stearothermophilus Mycobacterium senegalense acute respiratory syndrome addition airborne disinfection Bacillus subtilis can be used carrier coated with Community complex Concentration concentrations coronavirus coronavirus 2 determine develop Disinfection Dry dry fog effective Efficacy fogging Hospital wards hydrogen peroxide inactivated inactivation Indiana vesiculovirus (VSIV) infectious agent Laboratory limitation methodology microorganism microorganisms Murine norovirus (MNV) mycobacteria Neutral pandemic parameter peroxyacetic acid protocol public health emergency Quantitative reduction respiratory robust room disinfection Safe SARS-CoV-2 SARS-CoV-2 pandemic sensitivity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show spore spores temperature tested viral pathogen virus viruses [DOI] 10.1128/AEM.02019-20 PMC 바로가기 [Article Type] Environmental Microbiology
Bacillus subtilis PB6 Supplementation in Weaned Holstein Steers During an Experimental Salmonella Challengearticle Published on 2020-08-312024-09-01 Journal: Foodborne Pathogens and Disease [Category] 살모넬라증, [키워드] Bacillus subtilis Calves CLOSTAT Probiotic Salmonella [Article Type] article
Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms생물막 관련 독소 및 세포외 프로테아제는 Bacillus subtilis 생물막에서 경쟁자를 협력적으로 억제합니다Research Article Published on 2019-10-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate Alter antibiotic Antibiotics Antimicrobials assistance B . subtilis Bacillus subtilis Bacteria Bacterial bacterial composition biofilm Cell cells combating contribute Defense DEGs demonstrated diffusion Diseases effective eliminated excluded expression Extracellular food contamination growth impair Infectious diseases inhibit leads medium multicellular mutant mutations Neutral observation overexpression penetrate peptide Polymer polymers Prevent problem problems protease PROTECT Protein Regulatory required resistance gene resistance genes secreted solid medium Space suppress Taking Tolerance Treatment type strain upstream wild-type strain [DOI] 10.1371/journal.pgen.1008232 PMC 바로가기 [Article Type] Research Article
Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis펩티도글리칸 합성을 지원하는 포스포글루코사민 뮤타제로서의 바실러스 서브틸리스 PgcA 월광Research Article Published on 2019-10-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amino sugar B . subtilis Bacillus subtilis Bacterial binding biosynthesis pathway cell wall cell wall synthesis contribute convert dual enzyme Enzymes Evidence function functional Gain gain-of-function glucosamine Glucose glucose 1-phosphate glucose 6-phosphate increase interact isomerization member mutant Mutation overproduction pathway peptidoglycan PG synthesis phosphate phosphoglucomutase positive precursor subset substrate substrates sugar sugar moiety sugars Support suppresse suppressed synthesis teichoic acid transfer [DOI] 10.1371/journal.pgen.1008434 PMC 바로가기 [Article Type] Research Article