betacoronaviruses – Page 2 – Communicable Diseases Research

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

SARS-CoV-2 RNA 의존성 RNA 중합효소의 돌연변이는 별개의 메커니즘으로 렘데시비르에 대한 내성을 부여합니다

Article

Published on 2022-08-032022-09-11
Journal: Science Translational Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제,

Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines

S1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도

Article

Published on 2022-07-132022-09-11
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of interest wild-type wild-type SARS-CoV-2
[DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article

SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent origin

SARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis approaches assays Autoimmune disease Autoimmune diseases Betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology
[DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication

SARS-CoV-2 N 단백질은 바이러스 복제를 촉진하기 위해 G3BP와 상호작용하여 스트레스 과립 조립 및 IFN 생산을 길항합니다

Article

Published on 2022-06-222022-09-11
Journal: Journal of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] A549 cell line A549 cell lines Antiviral assembly betacoronaviruses bind causative agent contribute coronavirus disease Coronavirus disease 2019 COVID-19 Evidence G3BP1 G3BP2 global health Granule Health IFN in vitro in vivo Innate immunity interferon knockout mice knowledge live SARS-CoV-2 lung viral load mechanism mice N protein nucleocapsid nucleocapsid protein pandemic pathogenic pathogenicity Production Protein provide recent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 pathogenesis SARS-CoV-2 virus SARS-CoV-2 virus infection SFTPC significantly higher Stress stress granule suppress the SARS-CoV-2 viral genome viral infection viral particle viral RNA genome virus infection viruses wild-type
[DOI] 10.1128/jvi.00412-22 PMC 바로가기 [Article Type] Article

Broadly Neutralizing Antibodies to SARS-CoV-2 Provide Novel Insights Into the Neutralization of Variants and Other Human Coronaviruses

SARS-CoV-2에 대한 광범위 중화 항체는 변이체 및 기타 인간 코로나바이러스 중화에 대한 새로운 통찰력 제공

Article

Published on 2022-06-162022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Human Superantibodies to 3CL pro Inhibit Replication of SARS-CoV-2 across Variants

3CL pro에 대한 인간 초항체는 변이체 전반에 걸쳐 SARS-CoV-2의 복제를 억제합니다

Article

Published on 2022-06-132022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종,

IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

뚜렷한 계절성 코로나바이러스-보존 SARS-CoV-2 스파이크 하위 도메인을 표적으로 하는 IgG는 차별적인 COVID-19 질병 결과와 상관관계가 있습니다

Article

Published on 2022-05-312022-09-11
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] Activation ADE amplification anti-Spike IgG anti-spike IgG levels anti-spike IgG response Anti-spike IgG responses antibody antibody-mediated effector responses Betacoronavirus betacoronaviruses caused conserved convalescent individual coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity CoVs CP: Immunology CP: Microbiology cross-reactivity Deleterious disease disease severity Early detection epitope Epitopes Fc-gamma receptor activation FcγR fusion protein fusion protein region greater heptad repeat heptad repeat region human betacoronavirus human betacoronavirus. humoral IgG IgG responses immunodominant epitope immunology lowest memory response Microbiology observé OC43 offer outcome predict profile Protective recall receptor responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS1 seasonal coronaviruses severe COVID-19 patient severe COVID-19 patients severe disease significantly Spectrum Spike protein the SARS-CoV-2 virus β-CoVs
[DOI] 10.1016/j.celrep.2022.110904 PMC 바로가기 [Article Type] Article

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

임상적으로 승인된 약물인 Acriflavine은 SARS-CoV-2 및 기타 베타 코로나바이러스를 억제합니다.

Article

Published on 2022-05-192022-09-11
Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 신약개발, 치료제,

Correlated sequence signatures are present within the genomic 5’UTR RNA and NSP1 protein in coronaviruses

코로나바이러스의 게놈 5'UTR RNA 및 NSP1 단백질 내에 상관된 서열 서명이 존재합니다

Article

Published on 2022-05-012022-09-11
Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

First detection of Hedgehog coronavirus 1 in Poland

Article

Published on 2022-02-112022-10-29
Journal: Scientific Reports [Category] Coronavirus,