Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike ProteinArticle Published on 2024-01-052024-09-05 Journal: Antibodies [Category] update2024, [키워드] betacoronaviruses mAb panel Neutralizing antibodies Pancoronavirus pandemic preparedness SARS-CoV-2 [DOI] 10.3390/antib13010005 PMC 바로가기 [Article Type] Article
Intragenomic rearrangements involving 5′-untranslated region segments in SARS-CoV-2, other betacoronaviruses, and alphacoronavirusesarticle Published on 2023-02-252024-09-05 Journal: Virology Journal [Category] update2024, [키워드] alphacoronaviruses betacoronaviruses Intragenomic rearrangements variants [DOI] 10.1186/s12985-023-01998-0 PMC 바로가기 [Article Type] article
Structural Analysis of the Spike Protein of SARS-CoV-2 Variants and Other Betacoronaviruses Using Molecular DynamicsArticle Published on 2022-12-052023-07-10 Journal: Chemphyschem : a European journal of chemical physics and physical [Category] COVID19(2023년), [키워드] betacoronaviruses molecular dynamics principal component analysis protein structures. SARS-CoV-2 [DOI] 10.1002/cphc.202200382
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS-CoV-2Article Published on 2022-11-082022-11-15 Journal: EMBO Molecular Medicine [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 Administered administration ameliorated Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody betacoronaviruses bind catalytic activity catalytically active Clinical use COVID-19 decoy demonstrated effective entry receptor High dose Host increased survival Infection Inflammation inoculated intravenous intravenously K18-hACE2 mice Loss Lung injury mechanism neutralization potency neutralize omicron Omicron variant persist PROTECT receptor reduced sACE2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants shown substrate target the SARS-CoV-2 therapeutic efficacy therapeutic potential Treatment virus [DOI] 10.15252/emmm.202216109 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virionsArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] 6-Thioguanine ACE2-expressing cells acting antiviral activity antiviral drug antivirals approach Betacoronavirus betacoronaviruses biochemical Cell complementary coronavirus demonstrated early stage ectopic expression Effect full-length Genetic GTPase had no HCoV-OC43 HPRT1 in vitro infect Infection inhibit inhibitor lentivirus nucleotide oligosaccharide outcome progeny virion Protein pseudotyped pseudovirus Replication SARS-CoV-2 selective shown spike structural proteins subgenomic RNA target Treatment Viral diseases viral genomes Virus-like particle VLPs yielding [DOI] 10.1371/journal.ppat.1010832 PMC 바로가기
Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigensArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibody Antigen assist Betacoronavirus betacoronaviruses bioinformatic analysis convalescent coronavirus cross-reactive cross-reactive antibodies cross-reactive antibody diagnostics Donor donors Effectiveness fatality functional individual mapped mapping monoclonal natural human antibody neutralization potency Next-generation sequencing NGS non-specific Patient performed produced response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specificity tested the antibody Transmissibility unique Vaccines yeast yeast display [DOI] 10.3389/fimmu.2022.977064 PMC 바로가기
Serological screening in wild ruminants in Germany, 2021/2022: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virusArticle Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age antibodies antibody betacoronaviruses bluetongue disease bovine viral diarrhoea collected coronavirus COVID-19 deer disease ELISA Germany human SARS-CoV-2 infectious agent investigated no evidence of occurred pandemic pathogenic Pestivirus positive presence of antibody public health RBD risk ruminant ruminants SARS-CoV-1 SARS-CoV-2 scored Serologically serology Spread susceptible tested the RBD the receptor-binding domain the SARS-CoV-2 virus Virus neutralisation while wildlife [DOI] 10.1111/tbed.14600 PMC 바로가기
Broadly neutralizing antibodies target the coronavirus fusion peptide광범위 중화 항체는 코로나바이러스 융합 펩티드를 표적으로 한다Article Published on 2022-08-122022-09-12 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha antibodies antibody approach arginine residue betacoronaviruses caused cleavage site conserved coronavirus coronavirus vaccine Coronaviruses crystal structure disease epitope fusion peptide helical structure highlight identify include monoclonal antibody neutralize neutralizing antibody omicron outbreak Pathogens Receptor binding SARS-CoV-2 Seven Spike protein the SARS-CoV-2 [DOI] 10.1126/science.abq3773 PMC 바로가기 [Article Type] Article
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodiesACE2 결합은 코로나바이러스 항체를 광범위하게 중화시키는 SARS-CoV-2 융합 펩타이드를 노출시킵니다Article Published on 2022-08-122022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha alpha- Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal coronavirus Animal coronaviruses antibody approach betacoronaviruses binding breadth breath conserved coronavirus coronavirus spike protein donors enzyme epitope functional fusion peptide hidden host receptor Host receptors immune in vitro in vivo mAb mAbs monoclonal antibodies monoclonal antibody motif neutralize Neutralizing Neutralizing activity omicron pathology peptide prefusion recognize reduce respiratory SARS-CoV-2 selected Seven severe acute respiratory syndrome Coronavirus somatic mutations spike glycoprotein Spike proteins the SARS-CoV-2 Viral viral burden virus viruses [DOI] 10.1126/science.abq2679 PMC 바로가기 [Article Type] Article