Hidden in Plain Sight: Natural Products of Commensal Microbiota as an Environmental Selection Pressure for the Rise of New Variants of SARS-CoV-2잘 보이지 않는 곳에 숨겨져 있음: SARS-CoV-2의 새로운 변종 증가를 위한 환경 선택 압력으로서 공생 미생물군의 천연 산물Review Published on 2021-10-132022-09-11 Journal: Chembiochem [Category] SARS, 변종, [키워드] ACE2 receptor Affect Bacteria bile acid bile acids binding binding affinity binding pocket commensal commensal microbiota future work Interaction interfere metabolite microbiota molecular docking Mutation N501Y N501Y mutation natural natural products New NRPs peptide peptides predict predicted pressure produced product RBD Receptor binding domain reduce respiratory tract respiratory virus respiratory viruses SARS-CoV-2 Selection spike glycoprotein stimulate the binding affinity the RBD variant viral infection virus wild-type [DOI] 10.1002/cbic.202100346 PMC 바로가기 [Article Type] Review
A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis빌리루빈 유래 나노의약은 폐 섬유증의 병리학적 캐스케이드를 약화시킵니다Article Published on 2021-08-012022-09-11 Journal: Biomaterials [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory Anti-inflammatory effects antioxidant antioxidants Antioxidative ARDS attenuate bile acid Bilirubin Bilirubin nanoparticles Biomarkers Bleomycin blood circulation cascade caused Clinical sign Clinical signs COVID-19 COVID-19 infection disease fibrosis histological Immune cell immune cells incidence life-threatening mice nanomedicine outbreak oxidative damage pulmonary pulmonary fibrosis reduce respiratory distress SARS-CoV-2 SARS-COV-2 infection shown syndrome the disease therapeutic options therapeutic potential [DOI] 10.1016/j.biomaterials.2021.120986 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiotaResearch Article Published on 2021-03-082022-10-31 Journal: Gut Microbes [Category] COVID-19, [키워드] 16S rRNA gene Acinetobacter acute respiratory syndrome Alter alteration Analysis Bacterial bile acid change changes in Community coronavirus coronavirus disease correlated correlation COVID COVID 19 Effect Fatty acid firmicutes functional global public health Gut gut dysbiosis gut microbiota in viral indicated Infection metabolic output metabolite metabolomics microbiota mild COVID-19 symptoms nonhuman primates opposite pandemic parameters positively correlated Post-infection Proteobacteria Quantitative respiratory infections SARS-CoV-2 SARS-COV-2 infection SCFAs significant changes in Streptococcus systemic inflammatory marker the gut-lung axis upper respiratory tract [DOI] 10.1080/19490976.2021.1893113 PMC 바로가기 [Article Type] Research Article
Depletion of cholesterol could be associated with modulation of progesterone but not other sex hormone levels during Plasmodium falciparum infection in humans: a cross-sectional study from Zaria, Nigeriaarticle Published on 2020-12-312024-09-01 Journal: Parasitology Research [Category] 말라리아, [키워드] bile acid cholesterol Plasmodium falciparum Steroid hormones Vitamin D [Article Type] article
Genetic determinants of gut microbiota composition and bile acid profiles in mice생쥐의 장내 미생물 조성 및 담즙산 프로필의 유전적 결정인자Research Article Published on 2019-08-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abundance Analysis approach Author Bacterial bile acid bile acids can be used changes in characterized cholic acid distal Diversity Effects eight environmental cue environmental cues experiment fecal Follow-up Gene Expression generate Genetic genetic determinant genetic differences Genetic variant genetic variants Genetic variation genetics Genome genomic region genotypic data Gut gut bacteria gut microbiota composition homeostasis hormone Hormones Host host genetics Human hypothese Hypothesis ileal influence Inter-individual variation Interaction interactions intestinal loci locus mammal mapped mechanism mediation Mediation analysis metabolism metabolites mice microbes Microbial communities microbial community microbiota overlapping plasma produced profile profiles QTL Quantitative quantitative trait locus Slc10a2 strain Strains subsequent sucrose Variation variations while [DOI] 10.1371/journal.pgen.1008073 PMC 바로가기 [Article Type] Research Article
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signalsCspC pseudoprotease는 여러 환경 신호에 대한 응답으로 Clostridioides difficile 포자의 발아를 조절합니다Research Article Published on 2019-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alter Amino acid Bacteria bile acid bile acids calcium Clostridioide Clostridioides conserved Critical crystal structure detect dormant exhibited function germination Gut hypo induce Infection initiate involved lack mammalian mechanism mechanism of action Mutation nosocomial Organisms pathogen physically question raise receptor regulate residue sensitivity Signaling small molecule Small molecules spore thought transmembrane unique variant while [DOI] 10.1371/journal.pgen.1008224 PMC 바로가기 [Article Type] Research Article
[From the Establishment of Hepatitis B Virus Cell Culture Systems to Drug Discovery]Review Published on 2019-01-012023-06-16 Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Category] B형 간염, [키워드] bile acid cell culture system Entry Hepatitis B virus inhibitor sodium taurocholate cotransporting polypeptide [DOI] 10.1248/yakushi.18-00164-4 [Article Type] Review
Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced CirrhosisArticle Published on 2016-04-012023-06-15 Journal: Journal of Proteome Research [Category] B형 간염, [키워드] bile acid Child-Pugh classification cirrhosis hepatitis B serum [DOI] 10.1021/acs.jproteome.5b00217 PMC 바로가기
Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced CirrhosisArticle Published on 2016-04-012023-06-15 Journal: Journal of Proteome Research [Category] B형 간염, [키워드] bile acid Child-Pugh classification cirrhosis hepatitis B serum [DOI] 10.1021/acs.jproteome.5b00217 PMC 바로가기