binding epitope – Page 2 – Communicable Diseases Research

In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate Vaccine

SARS-CoV-2 예측 에피토프 기반 후보 백신의 In Silico 및 In Vivo 평가

Article

Published on 2021-10-132022-09-10
Journal: Molecules
[Category] MERS, SARS, 진단, 치료기술,

Analysis of the molecular mechanism of SARS-CoV-2 antibodies

SARS-CoV-2 항체의 분자 메커니즘 분석

Review

Published on 2021-08-202022-09-11
Journal: Biochemical and Biophysical Research Communication
[Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] antibody antibody cocktail beta-coronavirus binding domain binding epitope caused Chinese death effective epitope Epitopes human cells include infect Infection mechanism molecular mechanism monoclonal antibodies monoclonal antibody neutralize Neutralizing activity NTD pandemic provide RBD Receptor binding domain receptor binding domain (RBD) Region reported Research respiratory Respiratory disease S protein S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 mutants SARS-CoV-2. Spike proteins TCM the antibody the S protein the SARS-CoV-2 the spike protein therapy Traditional Chinese medicine Treatment treatment strategy Vaccine vaccine therapy WHO
[DOI] 10.1016/j.bbrc.2021.06.001 PMC 바로가기 [Article Type] Review

Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

SARS-CoV-2에 대한 체액성 면역의 동적 지형 매핑은 중요한 COVID-19 환자의 생존과 관련된 비구조적 단백질 항체를 식별합니다

Article

Published on 2021-08-172022-09-10
Journal: Signal Transduction and Targeted Therapy
[Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody Antibody Response Antibody responses binding epitope clinical variable clinical variables Cohort comprehensive analysis coronavirus correlation COVID-19 COVID-19 pathogenesis COVID-19 severity Critical critical COVID-19 patient diagnostics dynamic epitope Epitopes help high mortality high mortality rate humoral immune response Humoral immunity identify IgG antibodies IgG antibody IgM and IgG IgM antibodies IgM antibody immunogenic independent Infectious diseases innate immune response longitudinal analysis Microarray non-structural protein nonstructural protein nonstructural proteins Nsp3 Nsps nucleocapsid ORF3a Patient patients peptide peptide-based performed polyprotein Prognosis Proteases Protein respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 replication serum serum sample serum samples severe acute respiratory syndrome Coronavirus severity spike structural protein structural proteins survival therapy Transcription Treatment with COVID-19
[DOI] 10.1038/s41392-021-00718-w PMC 바로가기 [Article Type] Article

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

Article

Published on 2021-08-032022-10-04
Journal: Nature Communications
[Category] MERS, SARS, 변종,

[키워드] ACE2-binding site acute respiratory syndrome Analysis antibodies Antiviral bind binding binding epitope circulating variant circulating variants class comparison conserved coronavirus COVID-19 therapeutics cryo-EM structures Cryoelectron microscopy determine disrupt effective eight epitope host receptor inaccessible indicate mechanisms Microbiology Microscopy nanobody neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody neutralizing epitope potent provided RBD Receptor binding domain recognize reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Spike protein STABLE structural biology Structure target the SARS-CoV-2 unique Vaccine variant variants of concern variety virus VoC VOCs
[DOI] 10.1038/s41467-021-24963-3 PMC 바로가기 [Article Type] Article

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

초기 환자 반응의 심층 마이닝에서 교차 반응성 SARS-CoV-2 중화 항체

Immunology

Published on 2021-06-152022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 변종, 진단,

[키워드] affected antibodies antibody antibody repertoire Antibody Response approach B cell B.1.1.28 B.1.1.7 B.1.351 BCR binding binding epitope blocking antibody Brazil conserved convergence COVID-19 cross-reactivity deep described epitope Epitopes highlight hospitalized COVID-19 patient hospitalized COVID-19 patients independent monoclonal antibodies monoclonal antibody Mutation Neutralizing antibodies neutralizing antibody occur passive immunization Patient phage display RBD binding receptor reduced reported response reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variants sensitivity sequence sequences Sequencing South Africa study group the RBD unlikely Vaccine Viral viral variant Viral variants
[DOI] 10.3389/fimmu.2021.678570 PMC 바로가기 [Article Type] Immunology

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern

우려되는 SARS-CoV-2 변이체에 대한 중화 항체의 에피토프 분류 및 RBD 결합 특성

Immunology

Published on 2021-06-042022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 binding ACE2 binding affinity acute respiratory syndrome acute respiratory syndrome coronavirus Against Analysis angiotensin angiotensin converting enzyme antibody bind binding binding affinity binding epitope C1D cause Cell classification concern coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID19 death disease disrupting E484K ENhance enzyme epitope mapping Epitopes evade evaluated exhibited Host immune response hosts interactions L452R less mutant N501Y NAb NAbs Naturally Neutralizing antibodies neutralizing antibody P.1 predict promote property Protein quantified RBD RBD binding RBD variant RBD variants Receptor binding domain representing respiratory responsible SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 WT sensitivity sequence variation Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike Strains surface area susceptible susceptible hosts the RBD the SARS-CoV-2 therapeutic option Treatment variant variant of concern Viral viral infectivity viral pathogenesis while Wuhan-1
[DOI] 10.3389/fimmu.2021.691715 PMC 바로가기 [Article Type] Immunology

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

신규 결합 에피토프를 갖는 SARS-CoV-2 중화 항체의 구조적 기초

Research Article

Published on 2021-05-072022-08-13
Journal: PLoS Biology
[Category] Biochemistry, SARS, 진단,

[키워드] ACE2 receptor acute respiratory syndrome coronavirus Ad5-hACE2 Ad5-hACE2 transduction mouse model angiotensin antibodies antibody antiviral efficiency applied binding binding epitope caused characterized coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 domain Economy epitope Epitopes global public health H2L2 platform H2L2 transgenic mice hACE2 help High-resolution X-ray crystallography structures human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human immunoglobulin human immunoglobulin variable regions humanized NAb identify immunize Immunoglobulin injection mAb mAb-related therapeutic intervention mAb-related therapeutic interventions monoclonal antibody mouse model NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody novel non-blocking epitope pandemic platform PR1077 PR953 PR961 Prophylactic provide provided RBD RBM receptor-binding motif recombinant vaccines regions respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein spike receptor-binding domain Structural analysis Structure subsequent tested the antibody the SARS-CoV-2 the spike protein therapeutic interventions therapy transgenic mice treatment groups variable regions X-ray crystallography
[DOI] 10.1371/journal.pbio.3001209 PMC 바로가기 [Article Type] Research Article

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

SARS-CoV-2 비-RBD 스파이크 에피토프의 만연, 보호 및 수렴형 IgG 인식

Report

Published on 2021-05-042022-09-10
Journal: Science (New York, N.y.)
[Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

Antibody Binding Epitope Mapping (AbMap) of Hundred Antibodies in a Single Run

단일 실행에서 100개 항체의 항체 결합 에피토프 매핑(AbMap)

Article

Published on 2021-01-012022-09-12
Journal: Molecular & Cellular Proteomics : MCP
[Category] 진단,

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

530

Published on 2020-10-132022-10-29
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID-19, MERS, SARS,

[키워드] Activation acute respiratory syndrome Adaptive immune response adaptive immune system adult COVID-19 patient adult COVID-19 patients Bacterial binding binding epitope caused children complex coronavirus Coronaviruses COVID-19 COVID-19 patient Cytokine storm disease Escalation European Excessive activation exhibit explain glycoprotein histocompatibility complex hyperinflammation Hyperinflammatory Hyperinflammatory syndrome implication include Infection Interaction intercellular MHCII MIS-C motif Mutation Pandemics pathogenic Patient residue SARS virus SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike SARS-related coronaviruses selected sequence severe COVID-19 patients Shock Significance skewed staphylococcal superantigen Support supported Symptom syndrome T cell T cell receptor T cell receptors TCR TCR binding TCRs the cytokine storm the receptor-binding domain the SARS-CoV-2 therapeutic approaches Toxic shock syndrome triggered TSS unique virus with COVID-19
[DOI] 10.1073/pnas.2010722117 PMC 바로가기 [Article Type] 530