APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical studyAPOE ε4는 심각한 CovID-19, 뇌 미세 조혈 및 침전 후 정신 피로의 위험 증가와 관련이 있습니다. 핀란드 바이오 뱅크, 부검 및 임상 연구Research Published on 2021-12-232022-09-01 Journal: Acta Neuropathologica Communications [Category] 진단, [키워드] age allele Analysis animal model animal models ApoE APOE4 APOE4 carriers Apolipoprotein e association Autopsy Biobank Brain Brain microhaemorrhage cardiovascular disease carriers clinical manifestation clinical manifestations clinical study Cohort Control COVID-19 COVID-19 case COVID-19 mortality COVID-19 sequelae datasets Evidence fatigue Finn Finnish Finns Genetic genetic association Genetic studies histopathological examination in some increased risk information initial intensive care patient intensive care patients Mental mental fatigue Neuropathology non-infected pathology perivascular post-COVID fatigue Post-viral fatigue prevalent provide provided risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Sex shown subject supplementary material susceptibility [DOI] 10.1186/s40478-021-01302-7 PMC 바로가기 [Article Type] Research
The DxConnect Virtual Biobank connects diagnostic researchers to clinical samples Correspondence Published on 2021-12-222022-10-05 Journal: Nature biotechnology [Category] 진단, [키워드] Biobank clinical sample diagnostic researcher [DOI] 10.1038/s41587-021-01168-z [Article Type] Correspondence
Circulating IgG Levels in SARS-CoV-2 Convalescent Individuals in CyprusArticle Published on 2021-12-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Abbott Laboratories age antibodies antibody Antibody Response arbitrary unit Biobank center circulating Clinical data conducted COVID-19 Cyprus evaluated Gender General population heterogeneity Hospitalized humoral IgG IgG antibody IgG response Immunoglobulin individual individuals Infection interquartile investigated Level males median Older parameters Participants peaked persistence RBD-specific IgG Receptor binding domain SARS-CoV-2 SARS-COV-2 infection severity of symptoms significantly Stata 16 statistical analysis Symptom symptom onset the RBD the SARS-CoV-2 university Variability were measured [DOI] 10.3390/jcm10245882 PMC 바로가기 [Article Type] Article
Soluble ST2 concentrations associate with in-hospital mortality and need for mechanical ventilation in unselected patients with COVID-19가용성 ST2 농도는 COVID-19로 선택되지 않은 환자의 병원 내 사망률 및 기계적 환기의 필요성과 관련이 있습니다.Observational Study Published on 2021-12-012022-09-11 Journal: Open Heart [Category] SARS, 바이오마커, 임상, [키워드] association baseline Biobank Biomarker Biomarkers cardiovascular disease Chronic kidney disease collected Comparisons Concentration COVID-19 demonstrated determine diabetes disease severity elevated Endothelial dysfunction enrolled fibrosis heart failure hospitalisation hospitalised patient Hospitalised patients hypertension hypoxaemia ICU ICU treatment In-hospital In-hospital death in-hospital mortality independent independent of Inflammation Inflammatory intensive care intensive care unit IQR Kidney disease lower oxygen saturation lung Lungs Male sex mechanical ventilation median Myocardial myocardial fibrosis non-survivor Non-survivors Older age outcome outcomes oxygen pathophysiological pathophysiology patients died patients with COVID-19 produced reflect registration number respiratory rate Risk factors robust SARS-CoV-2 smoking ST2 survivor thrombosis Treatment Viraemia with COVID-19 [DOI] 10.1136/openhrt-2021-001884 PMC 바로가기 [Article Type] Observational Study
Assessment of Macrophage Inflammatory Biomarkers and Neutrophil Extracellular Traps Associated Proteins in COVID-19 PatientsConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 바이오마커, [키워드] activate Activation acute respiratory distress Adaptive immune response age Analysis assessment Biobank Biomarker Blood cause cfDNA Characteristics chitinase circulating clinical clinical manifestations clinical variable Comorbidities contribute control group COVID-19 COVID-19 patient COVID19 critically ill patients cytokine Cytokine storm D-dimer database decrease demographic disease severity DNA download dysregulated immune response Elastase endothelial damage ethics committee European evaluate explained ferritin figure Follow-up GDPR group healthy control Hospitalization hospitalized patient Hypothesis increase in induce Infection Inflammation inflammation marker knowledge Macrophage macrophage activation Mann-Whitney U test marker microthrombi MPO multiple organ failure NET NETosis neutrophil Neutrophil extracellular trap Patient protection provided Research Result resulting routine clinical practice SARS-CoV-2 infected subjects SARS-COV-2 infection selected Septic shock severe complication severe COVID-19 disease shown statistical statistically significant stratified supported symptom onset syndrome System the median the patient thrombosis thrombotic complication Vascular damage were measured were used [DOI] 10.1182/blood-2021-148166 [Article Type] Conference abstract
Quality of Life (QoL) Is Reduced in Those with Severe COVID-19 Disease, Post-Acute Sequelae of COVID-19, and Hospitalization in United States Adults from Northern ColoradoArticle Published on 2021-10-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Adults alleviate Biobank Cohort collected COVID-19 COVID-19 severity demographic described disease severity enrolled evaluated Hospitalization Hospitalized implication indicate Intervention life limitation nasopharyngeal PASC PCR polymerase chain positive Post-acute sequelae of COVID-19 (PASC) Quality Quality of life question role SARS-CoV-2 scored SF-36 significantly lower Surveillance survivor Survivors Symptom the disease the United State United State [DOI] 10.3390/ijerph182111048 PMC 바로가기 [Article Type] Article
Uncovering Clinical Risk Factors and Predicting Severe COVID-19 Cases Using UK Biobank Data: Machine Learning ApproachOriginal Paper Published on 2021-09-302022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, [키워드] 95% CI abnormality Accuracy age analyses Analysis Atrial fibrillation AUC baseline Biobank Blood build cardiometabolic characteristic clinical clinical risk factor clinical variable Cohort collected Comorbidities Comorbidity Control Coronary artery disease covariate COVID-19 COVID-19 outbreak Dementia Demographic variables Deprivation disease disease severity distribution drug evaluate example Factor fatal infections fatality feature identify independent infected individual Infection infections Interaction involved machine learning machine learning model male Measures Medical informatics Mortality multiple comorbidities obesity objective Other outcomes pandemic parameters performed population level predict prediction prediction models Predictive predictors public health quantified Red cell renal function Replication required Result risk risk factor Risk factors Severe infection severity Sex susceptible type 2 diabete UK biobank UKBB variable Waist circumference was used were used WHR [DOI] 10.2196/29544 PMC 바로가기 [Article Type] Original Paper
COVID-19 in Pregnancy and Early Childhood (COPE): study protocol for a prospective, multicentre biobank, survey and database cohort studyObstetrics and Gynaecology Published on 2021-09-142022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, SARS, [키워드] Affect age Analysis Antenatal approval authority Biobank biological samples child health cohort study collected confidentiality COVID-19 COVID-19 group COVID-19 pandemic database different time point dissemination Epidemiology ethical committee Ethics examined Health healthcare Infant information knowledge Long-term follow-up multicentre National neonatology non-infected obstetrics outcome outcomes peer-reviewed positive Pregnancy pregnant women prospective cohort study protection questionnaire Result review SARS-CoV-2 Study protocol Swedish the SARS-CoV-2 with COVID-19 women [DOI] 10.1136/bmjopen-2021-049376 PMC 바로가기 [Article Type] Obstetrics and Gynaecology
Sex steroid hormones are associated with mortality in COVID-19 patients Level of sex hormones in severe COVID-19Observational Study Published on 2021-08-272022-10-04 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] affected age albumin androgen association binding Biobank center coronavirus disease COVID-19 COVID-19 patient Deceased died disease severity estradiol estradiol level hormone hospital Infection interquartile range investigated Level median men men and women Mortality mortality rate Multiple outcome Patient patients with COVID-19 plasma sample residual selected severe COVID-19 Sex sex hormone sex steroid SHBG significantly lower surviving patients Testosterone therapy university were used women [DOI] 10.1097/MD.0000000000027072 PMC 바로가기 [Article Type] Observational Study
Association of Sickle Cell Trait with Risk and Mortality of COVID-19: Results from the United Kingdom BiobankShort Report Published on 2021-08-152022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, [키워드] 95% CI 95% confidence interval Biobank black carrier confirmation coronavirus disease COVID-19 COVID-19 infection COVID-19 mortality diabete hemoglobin higher risk immune response increased risk individual individuals infection rate Mortality Mutation Odds ratio Result SCT Sickle sickle cell trait significantly higher tested United Kingdom [DOI] 10.4269/ajtmh.20-1657 PMC 바로가기 [Article Type] Short Report