mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cellsArticle Published on 2022-09-072022-11-16 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody antigen-presenting cells appear B cell biodistribution Cancer Cancer vaccine CD8 T cell changes in Clinical studies design-of-experiments methodology effective extrahepatic delivery histopathological Immune cell immune cell populations Immunity immunization Immunotherapy induce interferon liver LNP mechanism methodology mRNA mRNA expression non-human primate phagocyte provide response responses SARS-CoV-2 spleen stimulatory systemic T cell T cell response the vaccine Type vaccination Vaccine [DOI] 10.1016/j.ymthe.2022.07.007 PMC 바로가기
rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbitsrVSV-ΔG-SARS-CoV-2-S 백신: NZW 토끼에서 반복되는 근육내(IM) 독성, 국소 내성, 면역원성 및 생체 분포 연구Article Published on 2022-08-012022-09-11 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, 치료기술, [키워드] Administered animals antibody antibody levels Antibody titers Antigen assigned binding biodistribution biodistribution study body temperature body weight breath C-reactive protein change Clinical pathology Clinical signs clinical trial clinical trials correlated COVID-19 detection elicited evaluate Express followed by Gross High-dose high-dose group histopathological iliac lymph node immunogenicity inflammatory reaction injection intervals intramuscular intramuscularly Local local reactions Lymph node mesenteric lymph nodes Necrosis Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers New Nonclinical ophthalmology pathology Phase 2 platform Reactions repeated RNA Safe Safety SARS-CoV-2 SARS-CoV-2-S significant increase spleen stomatitis supported systemic the vaccine Tolerance Toxicity two group two groups Urinalysis vaccination Vaccine vaccine doses Vector-based vaccine vesicular stomatitis vesicular stomatitis virus Viremia VSV was performed [DOI] 10.1007/s00204-022-03302-5 PMC 바로가기 [Article Type] Article
Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID-19 and the need for biodistribution evaluations코로나19 유전자 백신의 면역 기전에서 항원 제시 과정의 역할과 생체 분포 평가의 필요성Article Published on 2022-08-012022-09-11 Journal: Scandinavian journal of immunology [Category] 유전자 메커니즘, [키워드] Antigen presentation biodistribution COVID-19 Genetic immunization mechanism role Vaccine [DOI] 10.1111/sji.13160 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
COVID-19 inflammation and implications in drug deliveryReview article Published on 2022-06-012022-10-05 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Anti-inflammatory anti-inflammatory agent Bioavailability biodistribution Biomimetics Bioresponsive carrier COVID-19 Cytokine storm develop drug delivery Effects Evidence hyperinflammation Hyperinflammatory syndrome implication IMPROVE indicate Inflammation inflammatory pathway inherent Mesenchymal stem cells nanodecoys nanomedicine pandemic poor prognosis repress respond resulting SARS-CoV-2 second selective Severe case therapeutic strategy therapeutic target therapeutic targets [DOI] 10.1016/j.jconrel.2022.04.027 [Article Type] Review article
A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models자가 증폭 mRNA SARS-CoV-2 백신 후보는 전임상 모델에서 안전하고 강력한 보호 면역을 유도합니다Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] (Alpha) (Beta Alpha animals Antigen B.1.1.7 B.1.351 B.1.617.2 Beta biodistribution breath CD4 CD8 T cell CD8 T cell responses characterized clinical evaluation Delta demonstrated disease dose-dependent manner Efficacy elicit elicited emergency response Evidence evidence of Frequency Germinal center hamsters humans immune responses immunization immunogenicity induce Lipid nanoparticle Lipid nanoparticles LNP lower airways Messenger RNA mice mRNA neutralized no evidence of Phase 1 Protective protective immune response protective immunity RATs reduced response RNA RNA vaccines robust Safe safety profile SAM SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants SARS-CoV-2 Wuhan strain self-amplifying mRNA Spike antigen spike-specific antibody response T cell the SARS-CoV-2 the vaccine Tolerance Toxicity upper and lower airways Vaccine vaccine candidate variants Viral Viral load Wuhan-Hu-1 [DOI] 10.1016/j.ymthe.2022.01.001 PMC 바로가기 [Article Type] Clinical Trial
Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque쥐 및 붉은털 원숭이에서 침팬지 아데노바이러스 기반 COVID-19 백신의 비임상 면역원성, 생체 분포 및 독성 평가Article Published on 2022-05-012022-09-12 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Adenovirus adenovirus-based biodistribution candidate vaccine caused cellular Chimpanzee Chimpanzee adenovirus vector collected conditions coronavirus COVID-19 COVID-19 vaccine develop DNA dose effective Effective vaccines elicit ENCODE evaluated full-length spike protein global pandemic Humoral response immune response immunogenicity induce injected injection Intramuscular injection intramuscularly long-lasting morbidity and mortality Neutralizing antibody response organ polymerase chain profile qPCR quantified Quantitative rhesus rhesus macaque Safe safety profile SARS-CoV-2 serotype shown T cell responses Th1 toxicology Vaccine were given [DOI] 10.1007/s00204-021-03221-x PMC 바로가기 [Article Type] Article
Effect of mRNA Delivery Modality and Formulation on Cutaneous mRNA Distribution and Downstream eGFP ExpressionArticle Published on 2022-01-082022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] biodistribution Cell Cutaneous delivery distribution Effect Efficiency eGFP Ex vivo expressing expression facilitate fluorescent Formulation fractional laser ablation immunohistochemistry injection intradermal injection investigated Jet injection knowledge microneedle injection Microscopy modality mRNA mRNA delivery mRNA-based Protein protein expression responsible semi-quantitative therapeutic transcribed Visualization was used [DOI] 10.3390/pharmaceutics14010151 PMC 바로가기 [Article Type] Article
Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs3 개의 승인 된 siRNA (Patisiran) 및 mRNA (COVID-19 백신) 약물에 사용 된 지질 나노 입자 기술의 차이Review Published on 2021-12-012022-08-31 Journal: Drug metabolism and pharmacokinetics [Category] MERS, 치료제, [키워드] approval approved approved drug biodistribution Candidates coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine moderna difference drug drugs effective delivery Elasomeran Genes Ionizable lipid Lipid Lipid nanoparticles LNP Medicine Moderna mRNA mRNA vaccine mRNA vaccines mRNA-based Onpattro outbreak Patisiran Pfizer-BioNTech provided remained Safe SARS-CoV-2 siRNA target cell target cells Tozinameran translation [DOI] 10.1016/j.dmpk.2021.100424 PMC 바로가기 [Article Type] Review
SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice Research Published on 2021-11-232022-10-05 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 ACE2 expression angiotensin-converting enzyme 2 approach BALB/c mice bind binding binding domain biodistribution blocked C-terminus Cell COVID-19 distribution expression profile hACE2 high uptake in vivo Infection Inflammation inhibiting injection interact intrapulmonary Intravenous injection low-dose lung mammals metabolism mice moderate molecular Non-invasive organ pathway probe purification Radiation Radiotherapy RBD Receptor binding domain Recombinant spike protein reduce respiratory epithelial cells SARS-CoV-2 SARS-CoV-2 receptor Spike protein was obtained [DOI] 10.1038/s41401-021-00809-y [Article Type] Research