Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2게놈 전체의 CRISPR 화면은 ACE2의 변조를 통해 GATA6을 SARS-CoV-2의 프로바이러스 숙주 인자로 식별합니다.Article Published on 2022-04-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 Alpha Alpha variant Analysis anti-SARS-CoV-2 Beta biogenesis candidate cellular clathrin clinical sample clinical samples collected Comparative analysis component COVID-19 pathogenesis CRISPR CRISPR screen Critical data-set elevated facilitate Factor GATA6 Health heparan sulfate Host host gene host genes identify infected individuals Infection KREMEN2 list loss-of-function modulation pathway pharmacological phosphatidylglycerol regulate required SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SETDB1 Spread sulfate target therapeutic interventions therapeutic strategy Transcription transcription factor Transport unique variant variants of concern variants of SARS-CoV-2 viral infectivity virus pathogenesis VoC VOCs wild type Zinc [DOI] 10.1038/s41467-022-29896-z PMC 바로가기 [Article Type] Article
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus viruses [DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article
Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity감소된 감염성과 함께 약독화된 바이러스의 방출을 초래하는 SARS-CoV-2 스파이크 팔미토일화 억제제의 식별Article Published on 2022-03-042022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acylation Antiviral antivirals biogenesis bis-piperazine C-terminal cysteine cysteine residue cytoplasmic DHHC9 domain ER and Golgi FIVE fusion Glycoproteins Golgi identification Infection Infectivity inhibit SARS-CoV-2 inhibitor interact Intervention knockdown membrane fusion palmitate palmitoylation palmitoyltransferase palmitoyltransferase inhibitor Particle piperazine post-translational modifications progeny virion Protein reduced Release released Result resulting S protein S-acylation SARS-CoV-2 SARS-CoV-2 S protein spike Spike mutant Spike protein Spike proteins the SARS-CoV-2 the spike protein transmembrane glycoprotein undergo virus [DOI] 10.3390/v14030531 PMC 바로가기 [Article Type] Article
Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevitySirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다Review Published on 2022-03-012022-09-11 Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn [DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review
hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAsCoronaviruses Published on 2022-02-102022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] activate acute respiratory syndrome airway analysed Analysis biogenesis Calu-3 Calu-3 cell cells circRNA co-expression cognitive coronavirus Critical downstream epithelial expression facilitate form heterogeneous hnRNP C Host human lung immunoprecipitation increase Infection Interaction knockdown MERS-CoV MERS-CoV infection Messenger RNA Middle East modulate mRNA mRNAs mTOR inhibitor nuclear OSI-027 Pathogenesis pathway phosphorylated physically reduced viral loads Replication respiratory syndrome coronavirus ribonucleoprotein RNA RNA binding protein SARS-CoV-2 SARS-CoV-2 replication shown significantly Specific subset suppressed systemically upregulated viral infections virus [DOI] 10.1080/22221751.2022.2032372 PMC 바로가기 [Article Type] Coronaviruses
Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV-2미토콘드리아 기능 장애: SARS-CoV-2의 신경병증 발생에 대한 서곡Article Published on 2022-02-022022-09-11 Journal: ACS chemical neuroscience [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] approach biochemical biogenesis Brain caused cellular organelle change changes in conditions Golgi apparatus heat heat-inactivated increase in increasingly limit lipid droplets lipids microglia microglia cells Mitochondria mitochondrial mitochondrial dysfunction molecular neuro-COVID. Neuroinvasive neurological Neuropathogenesis Neuropathology organelle oxygen progression Raman spectrometry reactive oxygen species reactive oxygen specy reduction in ROS SARS-CoV-2 SARS-CoV-2 virus Spike protein storage Therapeutic approach transformations treated [DOI] 10.1021/acschemneuro.1c00675 PMC 바로가기 [Article Type] Article
Generation of Spike-Extracellular Vesicles (S-EVs) as a Tool to Mimic SARS-CoV-2 Interaction with Host CellsSARS-CoV-2와 숙주 세포의 상호 작용을 모방하는 도구로 스파이크-세포외 소포(S-EV) 생성Article Published on 2022-01-032022-09-12 Journal: Cells [Category] SARS, 진단, [키워드] Analysis anti-ACE2 antibody biogenesis bronchial epithelial cell Cell cells characterized clinical trials co-expressed coding Colchicine collected COVID-19 drugs embryonic kidney endothelial EVs expressing Extracellular vesicles generate Generation host-virus interaction internalization mechanism Microscopy MIMIC non-transfected reduced S1 and S2 Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly spike Spike protein subunits the SARS-CoV-2 therapeutic Vesicle virus [DOI] 10.3390/cells11010146 PMC 바로가기 [Article Type] Article
Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formationArticle Published on 2021-12-142022-10-04 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] accumulated Alternative pathway analyzed Applying attenuate autophagy biogenesis Cell cellular chronic liver disease contribute COVID-19 different diseases disparate driving elevated fraction HCV hepatitis C virus highlighting host cell identify in viral involved Lipid mechanism membrane vesicle morphologically organelle pathway pharmacological phylogenetically proteomics purified recruited Replication responsible RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 replication therapy virus viruses [DOI] 10.1038/s41467-021-27511-1 PMC 바로가기 [Article Type] Article
Small Extracellular Vesicles and COVID19—Using the “Trojan Horse” to Tackle the GiantReview Published on 2021-12-012022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] approach biogenesis cell entry COVID-19 COVID-19 pandemic diagnostics eukaryotic cells EVs exhibited Exosome Exosomes extracellular vesicle Extracellular vesicles Host immune response indicate intercellular lipid bilayer mechanism physiological released researcher SARS-CoV-2 similarity Spread Structure therapeutic Topic Treatment viral infections viral spread viruses [DOI] 10.3390/cells10123383 PMC 바로가기 [Article Type] Review
Application of Stem Cell-Derived Extracellular Vesicles as an Innovative Theranostics in Microbial DiseasesMicrobiology Published on 2021-11-302022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome antimicrobial agents application Bacteria bacterial EVs biogenesis cell types clinical complication component coronavirus death demonstrated described develop diagnostic disease early diagnosis Efficiency Escherichia coli EVs Extracellular vesicles HBV HCV Hepatitis B virus hepatitis C virus HIV Human immunodeficiency virus Impact Infectious disease lipids mechanism microbes microbial MSC-derived EVs nucleic acids Organisms Particle pathogen pathogenic microorganism peptides physiological platform produced Proteins responsible RNA SARS-CoV-2 Staphylococcus aureus STEM stem cell stem cells Therapeutic approach Therapeutic strategies therapy translation Treatment Vesicle Viral EVs virus [DOI] 10.3389/fmicb.2021.785856 PMC 바로가기 [Article Type] Microbiology