MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cellsmicroRNA는 표적 세포로 거의 전달되지 않는 세포 외 소포의 작은 성분입니다.Research Article Published on 2021-12-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Alter analyzed applied approach Biological functions Blood cells carried Cell cell line cell lines cell types cell-to-cell communication cellular cellular membrane cellular membranes contribute defined document effector effectors Evidence EVs Exosome Exosomes experiments extracellular vesicle Extracellular vesicles fraction functional FUSE had no majority mammalian cells messenger RNAs microRNA MicroRNAs Microvesicles miRNA miRNAs mRNA mRNAs packaged purified Quantitative recipient regulate RNAs Sensitivity and specificity stability target target cell target cells target mRNA Transcriptome Vesicle vesicles Viral viral miRNAs [DOI] 10.1371/journal.pgen.1009951 PMC 바로가기 [Article Type] Research Article
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patientsPBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘, [키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic [DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article
In silico drug repurposing in COVID-19: A network-based analysisCovid-19의 Silico Drug Reperhing에서 : 네트워크 기반 분석Article Published on 2021-10-012022-08-31 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, 신약개발, 임상, 치료제, [키워드] addition Analysis analyzed antibodies Anticoagulants approach Blood cells bowel Central nervous system clinical clinical setting clinical trial clinical trials compounds conditions Corticosteroid Corticosteroids corticosteroids) COVID-19 COVID-19 patient COVID-19 patients de novo drug Drug discovery Drug repurposing examined faster healthy subjects heparin identify Inflammatory bowel disease inhibitor mandatory patients with COVID-19 priority public health emergency SARS-CoV-2 pandemic SCN5A septic Septic shock Shock transcriptomic data treat vaccination whole blood cell whole blood cells [DOI] 10.1016/j.biopha.2021.111954 PMC 바로가기 [Article Type] Article
Tocilizumab, blood cells, and mild COVID-19: delayed vascular protection by interleukin blockade?토실리주맙, 혈구, 경증 코로나19: 인터루킨 차단으로 혈관 보호 지연?Article Published on 2021-09-212022-09-12 Journal: European heart journal. Cardiovascular pharmacothe [Category] SARS, 진단, [키워드] Blood cells Mild Vascular [DOI] 10.1093/ehjcvp/pvab051 PMC 바로가기 [Article Type] Article
Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection염증의 내인성 조절은 무증상 또는 무증상 SARS-CoV-2 감염이 있는 임산부의 특징입니다.Article Published on 2021-07-292022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, [키워드] Activation Affect alteration anti-inflammatory cytokine anti-inflammatory cytokines antiviral immune response antiviral immune responses Asymptomatic Blood cells cell proliferation cytokine cytokine production Cytokines cytometry analysis D-dimer damages develop differentiation during pregnancy endogenous help heterogenous IL-10 IL-17 IL-6 Immune cell immune responses immunological change immunological changes increase in Inflammation Inflammatory interleukin lymphopenia marker mild SARS-CoV-2 infection mother neutrophil Neutrophils PD-L1 Peripheral blood plasma Plasma levels Pregnancy pregnant women preserved pro-inflammatory cytokines remain unchanged reported SARS-COV-2 infection Therapeutic strategies therapeutic strategy therapeutic target Translational immunology viral infection virus White blood cells [DOI] 10.1038/s41467-021-24940-w PMC 바로가기 [Article Type] Article
Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19심한 Covid-19를 가진 젊고 이전에 건강한 남성의 TLR7 변이체에 대한 유전자 스크리닝Clinical Trial Published on 2021-07-232022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] absence age blood cell Blood cells coding region Comorbidities Comorbidity COVID-19 database deficiency Deleterious determine Diagnosis Genetic genetic screening High-flow nasal oxygen host genetics imiquimod immunodeficiency in silico interferon interferon response IQR loss-of-function male median age men Mild missense variant oxygen Patient pre-symptomatic predicted predictors predisposition prospectively studied rare variant rationale reported required Result Risk factors SARS-CoV-2 Screening sequenced severe COVID-19 Stimulation Support the median the patient therapeutic interventions TLR7 treat Treatment type I underlie variant variants [DOI] 10.3389/fimmu.2021.719115 PMC 바로가기 [Article Type] Clinical Trial
Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19심각한 COVID-19의 주요 유전적 위치의 기초가 되는 변경된 혈구 특성Article Published on 2021-07-132022-09-11 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 변종, 유전자 메커니즘, [키워드] age and sex Altered Analysis association basophil Blood blood cell Blood cells Blood samples candidate gene CCR1 CCR2 CCR3 Cell complex coronavirus disease Coronavirus disease 2019 COVID-19 eosinophil Eosinophil count European examined expression Genetic groups identify increased risk individual locus Major men Meta-analysis monocyte monocyte count Monocytes neutrophil Older pathophysiological mechanism performed phenome Phenome-wide association study. phenotype Phenotypes positive predicted regulated risk severe coronavirus disease severe COVID-19 significantly tested traits UK biobank underlie variant White blood cell [DOI] 10.1093/gerona/glab035 PMC 바로가기 [Article Type] Article
Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients코로나19 환자에서 ACE2, 가용성 ACE2, 안지오텐신 I, 안지오텐신 II 및 안지오텐신-(1-7)의 발현이 조절됨Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] ACE2 ACE2 (Angiotensin Converting Enzyme-2) ACE2 expression ACE2 gene ACE2 mRNA ACE2 protein adverse effect adverse effects Affect alveolar Ang II angiotensin angiotensin I Angiotensin II binding blood cell Blood cells blood pressure blood pressure homeostasis Cell cell types cells circulating Concentration consequence coronavirus COVID-19 COVID-19 patient COVID-19 patients dysregulation enzyme etiological agent Evidence Express expression healthy controls healthy volunteers hypertension less lower expression membrane Monocytes outcome plasma plasma concentration Plasma levels pneumocyte Prevent proteolysis regulator Renin – Angiotensin – Aldosterone System sACE2 SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2-infected patients soluble ACE2 the SARS-CoV-2 These data Trigger Variation variations Viral virus [DOI] 10.3389/fimmu.2021.625732 PMC 바로가기 [Article Type] Immunology
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected PatientsSARS-CoV-2와 인플루엔자 바이러스 감염 환자 간의 전사 서명 차이Observational Study Published on 2021-05-312022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 임상, [키워드] adverse outcome adverse outcomes B cell blood cell Blood cells Cell cell cycle Complete Complication COVID-19 COVID-19 pathogenesis COVID-19 severity degranulation develop difference distress dramatic increase dysregulated dysregulation dysregulation of T cells Evidence feature gene expression pattern group healthy host response IFN immune profiling immune signature Immunoglobulin Increasing individuals individuals with COVID-19 infected individuals infected with SARS-CoV-2 Influenza influenza viruses involved life-threatening metabolism Neutrophils NK cells over-expression Patient provided reason reduction respiratory distress responses RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severity signature Symptom T cells Toxicity transcriptomic transcriptomic profile transcriptomic profiles website whole blood transcriptome [DOI] 10.3389/fimmu.2021.666163 PMC 바로가기 [Article Type] Observational Study
Transcriptional Start Site Coverage Analysis in Plasma Cell-Free DNA Reveals Disease Severity and Tissue Specificity of COVID-19 PatientsGenetics Published on 2021-05-282022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory distress affected Analysis antiviral activity Asymptomatic biological processe Biomarker blood cell Blood cells cell-free DNA cfDNA Characteristics Clinical management control group coronavirus disease Coverage COVID-19 COVID-19 patients COVID-19 progression COVID-19 severity critical condition Cytokine storm death demonstrated disease severity DNA downregulated gene evidenced feasibility function Gene Expression high risk immune system individual Infection involved lung cell lung cells mechanism noninvasive plasma plasma DNA provided Region SARS-CoV-2 Severe case severe COVID-19 patient severe COVID-19 symptoms Severe patient severe patients severe pneumonia Site the disease tissue tissue specificity transcriptional Transcriptome TSS coverage upregulated gene utility Variation viral replication [DOI] 10.3389/fgene.2021.663098 PMC 바로가기 [Article Type] Genetics