Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-care Research Published on 2022-05-242022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Affect amplify analytical sensitivity assays Cancer Cancer cells cervical cancer Combination complement demonstrated DNA Efficacy expression HPV Infection ISFET isothermal amplification limit of detection majority marker molecular target mRNA point-of-care resolved selected single copy strain tissue tissue samples tissues transcriptase transistor virus [DOI] 10.1038/s41598-022-12557-y [Article Type] Research
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination Reviews Published on 2022-03-072022-10-05 Journal: Nature reviews. Genetics [Category] 변종, 유전자 메커니즘, 치료제, [키워드] antibody Antiviral Cancer Cancer cells consequence Cytidine deaminase Deamination DNA DNA and RNA enzyme Factors function functional generate Genome genomic help IMPROVE Innate immune cells member Mutation nucleic acid substrate recent RNA similarity Transcriptome [DOI] 10.1038/s41576-022-00459-8 [Article Type] Reviews
Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown잘 분화된 간암은 ACE2 기능 장애와 대사 장애 사이의 잠재적 연관성을 보여줍니다Article Published on 2022-02-032022-09-10 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome coronavirus Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bile canaliculi bioinformatics bystander Cancer Cancer cells cancers Cell co-expression network coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 dataset DNA dysfunction endothelial cells enzyme Epigenetics analysis Express FIVE followed by functions Gene expression analysis Genomic analysis hepatic function hepatocytes High-resolution human liver Image analysis imaging immunohistochemistry Immunological techniques in vitro Inflammation liver Liver cancer Liver disease livers Localization Microarray Microscopy mRNA multiplex mutated oxidative stress POLE predicted promoter protein expression Quantitative receptor respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro Sequencing Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tissue TMPRSS2 TMPRSS2 expression transcriptomic transmembrane serine protease transmembrane serine protease 2 Tumor tumors Viral whole mount β-catenin [DOI] 10.1038/s41598-021-03710-0 PMC 바로가기 [Article Type] Article
Identification of potentially anti-COVID-19 active drugs using the connectivity MAP연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인Research Article Published on 2022-01-272022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus [DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article
SBSA: an online service for somatic binding sequence annotationSBSA: 체세포 결합 시퀀스 주석을 위한 온라인 서비스Article Published on 2022-01-112022-09-11 Journal: Nucleic Acids Research [Category] 변종, 유전자 메커니즘, [키워드] alteration approach binding Cancer cells candidate cause demonstrated efficient ETS1 Genome genomic variant genomic variants help hypotheses identify joint mechanism miRNA molecular Mutation nucleotide offer online tool Organisms polymorphism promoter region Proteins reference genome RNA sequence sequences single nucleotide Single nucleotide polymorphism Somatic somatic mutation subjects Support TERT TFS therapeutic transcription factor transcription factors variants [DOI] 10.1093/nar/gkab877 PMC 바로가기 [Article Type] Article
Immunoediting in SARS-CoV-2: Mutual relationship between the virus and the hostReview Published on 2022-01-102022-10-04 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome adaptive immune system Cancer Cancer cells caused clinical conditions coronavirus Coronavirus disease 2019 Course COVID-19 develop disease early infection effective effort Epitopes growth hallmark help heterogeneous HIV Host HTLV-1 immune response immune system in viral infected cell infected cells Inflammatory response inhibiting malignancy MHC I molecule modulating Mutation occur pathophysiological mechanism patients promote response SARS-CoV-2 suppresse the interferon the SARS-CoV-2 therapeutic strategy tumor cell untreated patients viral infection virus [DOI] 10.1016/j.intimp.2022.108531 PMC 바로가기 [Article Type] Review
Vulnerability of SARS-CoV-2 and PR8 H1N1 virus to cold atmospheric plasma activated mediaArticle Published on 2022-01-072022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, 신종인플루엔자, [키워드] A549 activated antiviral activity atmospheric Bacteria Biological physics Cancer cells Cell cells Cold demonstrated effective expression fungi H1N1 influenza H1N1 virus Health healthy induce Inflammation Influenza investigated lung cell media nitrogen PAM plasma Replication Research respiratory diseases SARS-CoV-2 Specy tissue Treatment treatments for COVID-19 viral infection virus vulnerability [DOI] 10.1038/s41598-021-04360-y PMC 바로가기 [Article Type] Article
Computational study, synthesis and evaluation of active peptides derived from Parasporin-2 and spike protein from Alphacoronavirus against colorectal cancer cellsCancer Published on 2021-12-222022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] 5-FU activated active against alphacoronavirus anticancer anticancer peptides binding Cancer cells Cell cells characterized Circular Colon cancer Colorectal cancer computational simulations Concentration Evidence exhibited experiments Fmoc synthesis HCoV-229E Hemolysis hemolytic activity human APN Interaction intrinsic apoptosis investigated kDa less mechanism of action molecular docking Parasporin PS2Aa1 peptide produced Protein receptor shown significantly lower Spike protein these compound Toxicity virus spike protein α-helix [DOI] 10.1042/BSR20211964 PMC 바로가기 [Article Type] Cancer
Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy유전자 요법에서 아데노 바이러스 생물학, 재조합 아데노 바이러스 및 아데노 바이러스 사용Review Published on 2021-12-142022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] adenoviral vector Adenovirus adenovirus-based best Biology Cancer Cancer cells Cancer immunotherapy Cell clinical trial clinical trials conditionally replicating adenovirus COVID-19 vaccine COVID-19 vaccines cytokine ENhance Gene therapy insertion kill m-CRA methodological Modification oncolytic virus Patients with cancer platform pluripotent stem cells promoter recombinant regenerative regenerative medicine replicate replication-defective adenoviral vector stem cell subsequent survivin therapeutic therapeutic effects therapy Tumor tumors Usage Vaccine Vaccines Viral viral replication virus wild-type [DOI] 10.3390/v13122502 PMC 바로가기 [Article Type] Review
3D culture of cancer cells in alginate hydrogel beads as an effective technique for emergency cell storage and transportation in the pandemic era대유행 시대에 비상 세포 저장 및 수송을 위한 효과적인 기술로서 알지네이트 하이드로겔 비드에서 암세포의 3D 배양Short Communication Published on 2021-12-062022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] SARS, 진단, 치료제, [키워드] addition alginate can be used cancer cell Cancer cells Cell cells conditions COVID‐19 Culture culture media effective Effectiveness faster feasible help Laboratory less measure outcome pandemic pandemic era proliferation Quantitative Research room temperature significantly subculture Support supported survival temperature tested trypan blue trypan blue staining viability were assessed [DOI] 10.1111/jcmm.17078 PMC 바로가기 [Article Type] Short Communication