Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발Article Published on 2022-06-182022-09-11 Journal: Journal of molecular modeling [Category] 신약개발, [키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus. [DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article
Assessment of antifungal efficacy of itraconazole loaded aspasomal cream: comparative clinical study이트라코나졸 로딩 아스파소말 크림의 항진균 효능 평가: 비교 임상 연구Article Published on 2022-05-042024-07-28 Journal: Drug Delivery [Category] 백선증, [키워드] aspasomes candidiasis clinical study Cream itraconazole tinea [DOI] 10.1080/10717544.2022.2067601 PMC 바로가기
COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention StrategiesCOVID-19 관련 칸디다증: 가능한 병리 기전, 소인 및 예방 전략Review Published on 2022-03-142022-09-11 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Bacterial bacterial and fungal infections Candida candidiasis caused Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical deficiencies effective Factor Factors fungal infections Hospitalized iatrogenic immune system Immunocompromised Immunocompromised patients iron knowledge molecular nosocomial outcome Pathogenesis pathophysiology Patient prevention preventive measure preventive measures public health SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 Strategy susceptible transmissions virulence while Zinc [DOI] 10.1007/s00284-022-02824-6 PMC 바로가기 [Article Type] Review
Detection of anti-Histoplasma capsulatum antibodies and seroconversion patterns in critically ill patients with COVID-19: An underdiagnosed fungal entity complicating COVID-19?COVID-19에 감염된 중환자에서 항히스토플라스마 캡슐화 항체 및 혈청전환 패턴의 검출: COVID-19를 복잡하게 만드는 과소 진단된 곰팡이 개체?Article Published on 2022-03-042022-09-11 Journal: Medical mycology [Category] MERS, SARS, 진단, 치료기술, [키워드] AIDS analyzed antibody Antibody titer Antibody titers Awareness baseline Bearing Buenos Aire Buenos Aires candidiasis classical clinician Co-infection COVID-19 pneumonia COVID-19-associated mycoses Critically ill Critically ill patient critically ill patients death detection Diagnosis died Endemic endemic area endemicity evaluated FIVE fungal fungal disease fungal infections fungus help Histoplasma Histoplasma capsulatum Histoplasmosis HIV/AIDS Hospitalized house ICU IgG antibodies IgG antibody in-house ELISA increased risk infections invasive Invasive pulmonary aspergillosis mind morbidity morbidity and mortality Mycoses Patient positive Prevent pulmonary aspergillosis reduce respiratory Respiratory failure Respiratory function risk risk factor SARS-CoV-2 Sepsis sera Seroconversion seronegative seropositive serum sample serum samples severe COVID-19 Severe COVID-19 pneumonia severe respiratory failure specific IgG antibodies Treatment with COVID-19 worsening [DOI] 10.1093/mmy/myac012 PMC 바로가기 [Article Type] Article
Root Causes of Fungal Coinfections in COVID-19 Infected PatientsReview Published on 2021-12-042022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] acute respiratory syndrome Antibiotics aspergillosis Aspergillus Candida candidiasis cause caused clinical manifestation co-infection risk factors Coinfection condition conscious coronavirus Corticosteroid Corticosteroids COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 patient cryptococcosis Cryptococcus neoforman deaths Diabetes Mellitus distribution dosage drug Factor fungal Fungal infection fungal pathogen fungi Healthcare provider hospitalizations Host hyperglycemia hypoxia identify immunosuppressants Immunosuppression increase in infect infections literature review measure mechanical ventilation Mucorale outcomes Patient physician risk factor root SARS-CoV-2 shown skewed Treatment with COVID-19 [DOI] 10.3390/idr13040093 PMC 바로가기 [Article Type] Review
Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review입원 환자에서 Covid-19의 구강 증상 : 체계적인 검토Systematic Review Published on 2021-11-272022-08-31 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, meta-analysis, SARS, [키워드] article candidiasis Case series case-control studies caused certainty certainty of evidence cheilitis conducted confirmed COVID-19 case COVID-19 COVID-19 disease Cross-sectional studies Frequency global pandemic Hospital admission Hospitalization hospitalized patients immunological impairment lesion Macroglossia manifestation Medical devices observational studies oral oral candidiasis oral cavity oral examination oral lesions oral manifestations oral ulcers Patient pressure ulcers Prone position protocol recognize retrospective review risk of bia SARS-CoV-2 Spread systematic review target tongue tongue lesions Web of Science [DOI] 10.3390/ijerph182312511 PMC 바로가기 [Article Type] Systematic Review
COVID-19 and Its Repercussions on Oral Health: A ReviewCOVID-19와 구강 건강에 미치는 영향: 검토Review Published on 2021-11-012022-09-10 Journal: Medicina [Category] MERS, SARS, 변종, 치료기술, [키워드] abdominal pain accompanied Adverse reaction Adverse reactions Anosmia candidiasis co-morbidities condition coronavirus COVID-19 COVID-19 patient COVID-19 patients dental medicine Deterioration diarrhea distress dysgeusia enanthema erythematous fatigue geographic tongue gravity hairy tongue Health Organization Hemorrhagic Hospitalized Hypogeusia include Infection involved knowledge lesion lesions life-threatening manifestation Manifestations morbidities mucosal mucosal lesions nasal congestion nausea nausea/vomiting necrotic ocular ocular symptoms oral Oral hygiene oral lesions oral manifestations pandemic patients with COVID-19 periodontal disease petechiae Poor oral hygiene presenting Repercussion reported respiratory distress review runny nose SARS-CoV-2 Severe infection SIGN simplex Symptom Symptoms temporomandibular disorders tongue Viral viral infection viral variant Viral variants vomiting World Health Organization Wuhan Wuhan, China [DOI] 10.3390/medicina57111189 PMC 바로가기 [Article Type] Review
Antibody responses to the SARS-CoV-2 vaccine in individuals with various inborn errors of immunity다양한 선천성 면역 오류가 있는 개인의 SARS-CoV-2 백신에 대한 항체 반응Article Published on 2021-11-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] adverse event adverse events affected age anti-S anti-S IgG anti-S IgG levels antibody Antibody Response Antibody titer Antibody titers Autoimmune B cells B-cell baseline candidiasis Care CD19 CD3 Cohort cohort of patient completion controls counseling COVID-19 COVID-19 vaccine Diagnosis dose evaluate Genetic Health Health care immune immune suppressants Immunity immunization immunization schedule immunized immunogenicity immunomodulators immunosuppressive drug immunosuppressive drugs Inborn errors inborn errors of immunity individual information Jak jak inhibitors janssen Johnson & Johnson less luciferase Luciferase immunoprecipitation system median medical records mRNA vaccine Patient patients plasma rate of seroconversion reported rituximab Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose Seroconversion single dose subsequent T cells the SARS-CoV-2 therapy These data thymoma Treatment Vaccinating Vaccine was collected were measured [DOI] 10.1016/j.jaci.2021.08.016 PMC 바로가기 [Article Type] Article
Candida spp. co-infection in COVID-19 patients with severe pneumonia: Prevalence study and associated risk factorsObservational Study Published on 2021-11-012022-10-05 Journal: Respiratory medicine [Category] 임상, [키워드] admitted to ICU Aspergillus C. albican Candida candidiasis clinical outcomes Co-infection COVID-19 COVID-19 patient determine develop diagnosis of COVID-19 Escalation Fungal infection ICU IFI Infection interferon isolate mortality rate Patient patients Pneumonia positive presenting Prevalence radiological involvement reported Result risk risk factor SARS-COV-2 infection severe pneumonia submitted suggested systemic systemic Candidiasis systemic steroids tested Tocilizumab Viral pneumonia [DOI] 10.1016/j.rmed.2021.106619 PMC 바로가기 [Article Type] Observational Study
Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral ImmunityHIV에서 COVID로의 Ezrin Peptide Therapy: 염증 억제 및 적응형 항바이러스 면역의 증폭Review Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activate adaptive adjuvant adjuvants Administered amino acids Anti-viral immunity antibody antibody titres B cell candidiasis chronic diarrhea Clinical studies clinical study Colon COVID Cytokines derivative diarrhea disappearance disease domain duodenum dysregulation effective ENhance enhancer enhancers Enterocolitis expression ezrin ezrin peptides FIVE gp120 HCV herpes herpes zoster HIV HIV-infected patients homologous HPV Human human respiratory viruses IL-6 immune responses Immunity Inflammation inflammatory complications Inflammatory cytokines Influenza Inhaled inhibition inhibitor inhibitors innate immune response innate immune responses mice Microbiome middle Mild-to-moderate mucosal Mutation normalization opportunistic infection opportunistic Infections outbreak peptide peptides Placebo Prevent produced Protein randomised receptor Registered replicated respiratory respiratory viruses resulting Russia SARS-CoV-2 SARS-COV-2 infection shown stomach synthetic synthetic peptides T cell therapy tissue repair treat Treatment ulceration vaccination Viral viral respiratory virus virus infection viruses Volunteer [DOI] 10.3390/ijms222111688 PMC 바로가기 [Article Type] Review