Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19 Research Published on 2022-03-222022-10-05 Journal: NPJ Genomic Medicine [Category] 바이오마커, 신약개발, 유전자 메커니즘, [키워드] Analysis application applied approach average CCR5 CCR9 complications Concentration COVID-19 COVID-19 severity CXCR6 disease expression Genes Gustatory higher risk host genetics Immunity implication individual Inflammatory locus methodology molecular mechanism much higher olfactory phenotype severe COVID-19 severe disease severity SLC6A20 traits transcriptomic [DOI] 10.1038/s41525-022-00296-y [Article Type] Research
The major genetic risk factor for severe COVID-19 is associated with protection against HIV심각한 COVID-19의 주요 유전적 위험 요소는 HIV에 대한 보호와 관련이 있습니다Article Published on 2022-03-012022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] carrier carriers CCR5 chemokine receptors chromosome chromosome 3 COVID-19 DNA down-regulated expression genetic risk factor genetic risk factors genetics Haplotype HIV HIV infection initiative lower risk modulate Nature outcome risk severe COVID-19 variant [DOI] 10.1073/pnas.2116435119 PMC 바로가기 [Article Type] Article
Potential Genes Associated with COVID-19 and ComorbidityCOVID-19 및 동반이환과 관련된 잠재적 유전자Research Paper Published on 2022-01-242022-09-10 Journal: International Journal of Medical Sciences [Category] 변종, [키워드] ACE AGT Analysis bioinformatics candidate gene CCR5 Comorbidities Comorbidity contribute Coronary artery Coronary artery disease coronavirus coronavirus disease COVID-19 CX3CR1 cytokine cytokine inhibitors cytokine receptor diabetes Diabetes Mellitus disease severity drug and vaccine development Efficacy enrichment analyses evaluated explain Factor Fenofibrate Genetic genetic factors GO term help hypertension IL1B IL1RN IL6 immune factor immune factors immune response IMPROVE individual Infection inhibitors Interaction involved KEGG KEGG pathway MBL2 NCBI NLRP3 non-immune nucleotides observé OMIM overlapping pathway Pathways performed personalised Polymorphisms Potential PPI Predictive Predictive value Prevent Prognosis protein-protein interaction provide RAAS receptor Result risk of infection SARS-CoV-2 serious COVID-19 severity signaling pathway signaling pathways susceptibility susceptibility gene TLR4 Treatment Vaccine Vaccine development Variation Viral viral infection Vitamin D with COVID-19 [DOI] 10.7150/ijms.67815 PMC 바로가기 [Article Type] Research Paper
Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection감염 후 최대 15개월까지 COVID-19(PASC)의 급성 후유증에서 CD16+ 단핵구에서 SARS CoV-2 S1 단백질의 지속성Immunology Published on 2022-01-102022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, [키워드] acute infection Affect analyzed B-cell CCR5 CD14+ CD16+ COVID-19 COVID-19 pandemic COVID-19 symptom elevated flow cytometric fractalkine full length healthy control healthy controls individuals infected individuals Infection Inflammation initial investigated mass spectrometry mechanism monocyte Monocytes mononuclear cells Month non-classical monocyte Non-classical monocytes PASC Patient patients Peripheral blood Post-infection S1 protein SARS CoV-2 SARS CoV-2 S1 protein SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 S1 protein sequence severe COVID-19 patient significantly statistically significant subset T-cell the SARS-CoV-2 Treatment [DOI] 10.3389/fimmu.2021.746021 PMC 바로가기 [Article Type] Immunology
Clinical Significance and Properties of IFN-γ+IL-17+ Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus InfectionArticle Published on 2022-01-012023-06-13 Journal: Digestion [Category] B형 간염, [키워드] Acute-on-chronic liver failure CCR5 CXCR3 IFN-γ+IL-17+ Th17 cells Regulatory Th cells. [DOI] 10.1159/000526924
Could the CCR5-Delta32 mutation be protective in SARS-CoV-2 infection?CCR5-Delta32 돌연변이가 SARS-CoV-2 감염을 보호할 수 있습니까?Article Published on 2021-12-162022-09-11 Journal: Physiological research [Category] SARS, 변종, [키워드] allele allelic CCR5 chemokine chemokines correlated COVID-19 COVID-19 case death European population Evidence Factor Frequency genetic background genetics HIV infection HIV-1 host genetics host responses in some Increasing involved Mutation outcome pandemic Population Predictive Prevalence proinflammatory Protective recent receptor risk SARS-CoV-2 SARS-COV-2 infection severity significantly statistically variant viral infections viruses [DOI] 10.33549/physiolres.934725 PMC 바로가기 [Article Type] Article
Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression선택된 유전 인자가 SARS-CoV-2 감염 및 COVID-19 진행에 대한 감수성에 미치는 영향Review Published on 2021-12-162022-09-11 Journal: Physiological research [Category] SARS, 변종, [키워드] ACE2 affected allele angiotensin Angiotensin-converting enzyme ApoE4 allele Blood Group CCR5 CD14 cells contribute coronavirus COVID-19 COVID-19 progression COVID-19 severity COVID-19 susceptibility disease severity Effect effort example Factor functional host immune system Human genome identify IL-10 Impact implicated in silico increased risk Intensive knowledge Knowledge deficit LZTFL1 Mortality OAS1 patients polymorphism Polymorphisms populations predictor predisposition Prevalence protein-coding gene protein-coding genes reported Research SARS-COV-2 infection selected severity shown silico studies susceptibility TMPRSS2 transferred variants Variation virus with COVID-19 [DOI] 10.33549/physiolres.934730 PMC 바로가기 [Article Type] Review
Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster생물 정보학 분석은 COVID-19 관련 대상 포진의 메커니즘으로 증강된 인터루킨-17 신호 전달을 제안합니다Article Published on 2021-12-012022-09-11 Journal: Environmental science and pollution research inter [Category] 대상포진, 두창, 수두, 유전자 메커니즘, 홍역, [키워드] Analysis ApoE ARSA Bioinformatic blistering CCR2 CCR5 cell differentiation correlation COVID-19 CRP CXCL13 cytokine cytokine receptor distribution dorsal root ganglia DRB1 EGFR ESR1 Genetic GP2 Herpe herpes zoster herpetic neuralgia HLA-A HLA-B HLA-DRB1 IL-17 IL10 IL17A IL5 IL6 IL7 Increasing indicated Interaction interleukin-17 involved Jak-STAT mechanism pathophysiological mechanism raise raised Rash receptor resulting risk SARS-CoV-2 Signaling STAT STAT3 subset suggested TECTA Th17 THBS1 TNF varicella Varicella zoster virus virus Zoster [DOI] 10.1007/s11356-021-15567-x PMC 바로가기 [Article Type] Article
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody LeronlimabCCR5 수용체 점유 분석 결과 항-CCR5 항체 레론리맙 치료 후 말초혈액 CCR5+CD4+ T 세포 증가Clinical Trial Published on 2021-11-192022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] antibody assays binding blockade Blood cancer progression CCR5 CD4 CD4+ T cell CD4+ T cells Cell circulating comparable Complete correlated Critical Defense Efficacy facilitate flow cytometric flow cytometry HIV Host Human humans immunological Impact in vivo increase in Increased independent Infectious disease lack macaque macaques Occupancy pathophysiological peripheral Peripheral blood plasma plasma concentration Receptor occupancy receptor occupancy (RO) resulting sensitivity statistically significant suppressed T cell therapeutic Treatment viral replication Viremia Weekly with HIV [DOI] 10.3389/fimmu.2021.794638 PMC 바로가기 [Article Type] Clinical Trial
Candidate genes of SARS-CoV-2 gender susceptibilityArticle Published on 2021-11-092022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome ADAM10 Affect Analysis applied association bioinformatics BST2 candidate cascade CCR5 complement Computational biology and bioinformatics coronavirus COVID-19 disease Effect effective ENPEP evaluate expressed GATA1 Gender Genetic genetics gonadal host cell human protein immunology Infection initiated Interaction IRF1 IRF2 likelihood men molecular outcome ovarian pandemic Pathways performed reaction receptor signaling response SARS-CoV-2 SARS-CoV-2 treatment SERPING1 severity of symptoms Sex difference susceptibility target the SARS-CoV-2 tissue TLR4 TLR7 TMPRSS2 Topic understanding Variation women [DOI] 10.1038/s41598-021-01131-7 PMC 바로가기 [Article Type] Article