CD3+ – Page 2 – Communicable Diseases Research

Early Response of CD8+ T Cells in COVID-19 Patients

Article

Published on 2021-12-032022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients

SARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다

Original Article

Published on 2021-11-232022-09-10
Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers
[DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article

Myocardial Pathology in COVID-19-Associated Cardiac Injury: A Systematic Review

Review

Published on 2021-09-082022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] abstracts ACE2 Acute heart failure Affect age Analysis analyzed Angiotensin-converting enzyme Autopsy cardiac caused CD3+ CD68+ macrophages CD8+ changes in clinical assessment conducted consequence Coronavirus disease 2019 COVID-19 COVID-19 patients database death died diffusion disease emerging disease heart heart failure histologic inclusion criteria infiltration inflammatory state information interquartile range IQR item lymphocyte men myocarditis Myocardium Necrosis offer organ organs pathological change pathological finding pathological findings Patient Perspective positive Postmortem Protein prothrombotic state reflected Reporting Research Respiratory failure review risk SARS-CoV-2 searched systematic review systemic inflammatory response tested the SARS-CoV-2 virus variable vessel women
[DOI] 10.3390/diagnostics11091647 PMC 바로가기 [Article Type] Review

Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study

Article

Published on 2021-06-172022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,

Relationship between lymphocyte subsets values and C-reactive protein in COVID-19 patients

코로나19 환자의 림프구 하위 집합 값과 C 반응성 단백질 간의 관계

Article

Published on 2021-05-012022-09-11
Journal: Cytometry. Part A : the journal of the Internation [Category] SARS, 바이오마커,

[키워드] absolute value absolute values age approach association Blood cells blood sample C-reactive protein Calabria CD16 CD16+ CD19 CD19+ CD3+ CD3+CD4+ CD3+CD8+ CD4+ CD56 CD56+ circulating collected containment measures correlated COVID-19 COVID-19 patient COVID-19 positive patient CRP Department Efficacy enrolled females Infectious disease Infectious diseases Inflammation Italy lymphocyte Lymphocyte subset males median value men negative correlation operator operators Patient patients with COVID-19 positive patients predict protocol ranged relationship response to therapy Sample SARS-CoV-2 specimen strength subset T cell T cells the median Therapeutic treatment therapy Treatment Univariate analysis virus spread WBC White blood cell White blood cells
[DOI] 10.1002/cyto.a.24327 PMC 바로가기 [Article Type] Article

Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies

Research

Published on 2021-04-012022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, MERS,

[키워드] acute phase addition Analysis analyzed approach CD3+ CD38 CD4+ CD79B CD8+ T cells change clinical disease Coagulation coexistent consecutive patients coronavirus disease (COVID-19) correlated correlation count COVID-19 COVID-19 patient COVID-19 patients Critical CyTOF cytokine Cytometry demonstrated Differentially expressed genes disease effector memory expressed expression First wave Gene expression profiling group Hematological malignancies Hematological malignancy Hospitalized Host immune response IFIT3 IL-6 Immune cell immune response indicate Inflammation intensive care unit involved IP-10 leukemia LIPI Low T3 syndrome marker mononuclear cell multiplex NanoString NLR NLRP3 outbreak Patient patients with COVID-19 PBMC performed Peripheral blood Pneumonia presenting radiologic reduced reduction reported Result Rome SARS-CoV-2 serum Serum level serum levels severe COVID-19 severity single-cell SOFA subtype supplementary material syndrome T lymphocytes target gene the disease thyroid function tissue damage TSS university
[DOI] 10.1186/s12967-021-02805-6 PMC 바로가기 [Article Type] Research

Monitoring peripheral neutrophil and T-lymphocyte subsets could assist in differentiating the severity and disease progression of coronavirus disease 2019

말초 호중구 및 T-림프구 하위 집합을 모니터링하면 코로나바이러스 질병 2019의 중증도와 질병 진행을 구별하는 데 도움이 될 수 있습니다

Research Paper

Published on 2021-03-312022-09-10
Journal: Aging (Albany NY) [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis analyzed Antiviral assist AUC baseline CD3+ CD3+CD4+ CD3+CD4+ T cells CD3+CD8+ CD4+ CD4+ T lymphocyte CD8+ T cells center characteristic clinical Clinical significance clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Cytotoxic T cell Cytotoxic T cells disease Disease progression evaluate expression help helper helper T cells lymphocyte Lymphocytes monitoring neutrophil neutrophil to CD4+ T lymphocyte ratio/N4R NK cell NK cells patients with COVID-19 peripheral lymphocyte Potential biomarker potential biomarkers progression Public receiver operating characteristic respiratory SARS-CoV-2 SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus severity subset T cell T cells T lymphocyte T-cell test negative therapy
[DOI] 10.18632/aging.202701 PMC 바로가기 [Article Type] Research Paper

Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19

Research

Published on 2021-03-172022-10-05
Journal: Modern pathology : an official journal of the Unit [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] analyzed association Autopsy cardiac CD3+ CD68+ macrophage Cell change changes Clinical features Comorbidities correlation COVID-19 determine duration of symptom dysfunction electrocardiographic Factor fatal COVID-19 glucocorticoid IL-6 blockade Immunosuppression incidence infected cells Infection infection with SARS-CoV-2 Inflammation inflammatory cell infiltration Injury laboratory measurements less lymphocyte Lymphocytes Macrophage median Myocardial myocarditis Myocardium pathological change Patient patients treated patients with COVID-19 positively correlated prevalent reported Retrospective study SARS-CoV-2 SARS-COV-2 infection transcriptomic while
[DOI] 10.1038/s41379-021-00790-1 [Article Type] Research

The Association between Obesity and Severity in Patients with Coronavirus Disease 2019: a Retrospective, Single-center Study, Wuhan

Research Paper

Published on 2021-02-182022-10-29
Journal: International Journal of Medical Sciences [Category] COVID-19, MERS,

[키워드] 95% CI addition alanine aminotransferase Analysis association BMI body mass index CD19+ CD3+ Cell cell count coronavirus disease Coronavirus disease 2019 COVID-19 Creatine kinase-MB Critical defined Diseases Endpoint endpoints enrolled Follow-up Glucose group hypertension increased the risk intensive care intravenous mechanical ventilation monocyte multiple logistic regression neutrophil counts no significant difference not affect obese patient obesity organ damage outcome overweight oxygen Patient patients with COVID-19 Prognosis proportion recruited Renmin Hospital retrospective risk risk factor severity significantly higher single-center study surviving patients triacylglycerol university uric acid was obtained White blood cells Wuhan
[DOI] 10.7150/ijms.54655 PMC 바로가기 [Article Type] Research Paper

Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical Monocytes

Immunology

Published on 2020-12-092022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] 28-day mortality acute respiratory syndrome Admission association Atypical CD14 CD3+ CD4+ cell CD8+ Cell cells characterized composed coronavirus coronavirus disease COVID-19 Diagnosis died early phase evaluated expression HLA-DR Immune profile immune profiling immunological change include Infection Inflammation Inflammatory biomarker IQR lymphocyte lymphocytopenia mean value median value monocyte Monocytes mononuclear cell mononuclear cells natural killer pathogen patients patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells phase Population Presence preserved reduced reduction responsible Result SARS-CoV-2 side scatter subpopulation
[DOI] 10.3389/fimmu.2020.560330 PMC 바로가기 [Article Type] Immunology