Assessing T-Cell Immunity in Kidney Transplant Recipients with Absent Antibody Production after a 3rd Dose of the mRNA-1273 VaccineArticle Published on 2022-10-152022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, [키워드] addition age analyzed antibody production Assessing association CD19+ CD3+ CD4+ CD8+ Cell-mediated immunity Cellular immune response Cohort complement Concentration COVID-19 COVID-19 vaccines dose effective Gender highlight humoral Humoral immunity IFN-γ immune independent variable interferon-gamma release assay kidney kidney transplant recipient Kidney transplantation Linear regression analysis lymphocyte mRNA-1273 mRNA-1273 vaccine patients positive Production recipient Responder SARS-CoV-2 SD Biosensor seronegative patient statistically significant Surveillance T cell response T cells tested Transplant [DOI] 10.3390/ijms232012333 PMC 바로가기
Immunogenicity profiling and distinct immune response in liver transplant recipients vaccinated with SARS-CoV-2 inactivated vaccinesArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-RBD antibody CD19 CD19+ CD3+ CD3+ CD19+ cell CD4+ cell CD4+ T cell Cell cells cellular immunity Clinical characteristics Concentration CXCL10 DNT effector memory enrolled groups humoral immune profiling immune response immune system immunogenicity immunotype inactivated Inactivated vaccine innate immune response liver liver transplant recipient Lymphocyte count monocyte NAb National Neutralizing Neutralizing antibodies neutralizing antibody plasma Population positive proportion provided recipient recipients reported responders responses SARS-CoV-2 SARS-CoV-2 inactivated vaccines severe adverse event single-cell T-cell three groups time TNF-alpha Type vaccination vaccination schedule were recorded [DOI] 10.3389/fimmu.2022.954177 PMC 바로가기
Convalescent plasma therapy for patients with severe COVID-19: A case series study중증 COVID-19 환자를 위한 회복기 혈장 요법: 사례 시리즈 연구Case Reports Published on 2022-08-052022-09-11 Journal: Medicine [Category] SARS, 치료제, [키워드] Administered allergic allergic reaction alleviation alleviation of symptoms analyzed antiviral drug antiviral drugs arterial oxygen saturation bilateral lungs C-reactive protein case sery CD3+ CD4 CD8+ cerebral infarction Chest computed tomography Clinical data clinically collected Computed tomography convalescent plasma coronavirus disease Coronavirus disease 2019 cough COVID-19 CP infusion diabetes dysfunction early treatment effective Efficacy and safety elevated exhibited female Fever hospital hypertension IMPROVE Infarction interleukin interleukin-6 investigated lack lesion lesions lymphocyte Lymphocytes male Mild multiple-organ oxygen oxygen saturation Patient patients plasma postoperative respiratory infectious disease Safe severe adverse reaction severe adverse reactions severe COVID-19 severe disease Shortness of breath subset Supportive treatments Symptom T lymphocyte T lymphocytes the patient therapeutic therapy Thyroid Thyroid adenoma treated Treatment underlying disease [DOI] 10.1097/MD.0000000000029912 PMC 바로가기 [Article Type] Case Reports
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA VaccinePfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필Article Published on 2022-07-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination was performed with COVID-19 [DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency공통 가변성 면역 결핍증에서 2개의 ChAdOx1 nCoV-19 후 BNT162b2 부스팅에 의해 유도된 특정 항체 및 T-세포 반응Article Published on 2022-06-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 immunoglobulin Anti-spike antibody autologous BNT162b2 BNT162b2 vaccine booster vaccination CD19 CD19+ CD3+ CD3+CD4+ CD3+CD8+ CD4+ CD45 CD45+ CD8+ Cell cell count cell counts cell-mediated response ChAdOx1 ChAdOx1 nCoV-19 changes in common common variable immunodeficiency common variable immunodeficiency (CVID) Control Coronavirus-2 COVID-19 infection cumulative cut-off value CVID decrease ELISPOT ELISpot assay evaluated except for flow cytometric healthy control healthy controls healthy individual healthy individuals humoral IFN-γ IFN-γ ELISPOT IFN-γ ELISpot assay IFN-γ producing T cells immune response immunodeficiency Immunoglobulin Immunoglobulin G immunosuppressive immunosuppressive therapy individual interferon interferon-γ Killer cell less Lymphocytes measure morbidity natural killer natural killer cell not different not significant Patient patients positive Primary Immunodeficiency producing protein S raised receiving response Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown Side effects significant difference significant differences significantly significantly lower Specific statistically stem cell Stem cell transplantation T cell T cell response T cells tested therapy These data vaccination Vaccinations variable virus-specific T cell virus-specific T-cell with COVID-19 [DOI] 10.3389/fimmu.2022.907125 PMC 바로가기 [Article Type] Article
Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients심장 염증 및 미세혈관 응고촉진제 변화는 1차 물결로 사망한 COVID-19 환자에 비해 2차 물결에서 감소Article Published on 2022-02-152022-09-12 Journal: International journal of cardiology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied addition analyzed Anticoagulant cardiac Cardiac pathology CD3+ CD45+ CD68+ change CML Cohort control patient COVID-19 COVID-19 patient COVID-19 patients Deceased decrease disease course DPP4 dysfunction Evidence Factor factor VII factor XII fatal COVID-19 First and second wave First wave heart infiltration Inflammation Injury leukocyte lymphocyte lymphocytic myocarditis Macrophage majority marker Microvascular thrombosis Mortality Necrosis Non-COVID-19 Occurrence pandemic patients peptidase procoagulant procoagulant factor Protein quantified reported second wave shown significant decrease significantly significantly lower T lymphocyte Thrombosis microvasculature. Treatment use of steroid [DOI] 10.1016/j.ijcard.2021.11.079 PMC 바로가기 [Article Type] Article
In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma ProductionArticle Published on 2022-02-072022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Analysis CD3 CD3+ CD4/CD8 CD4+ CD8+ Characteristics COVID-19 COVID-19 patients demonstrated gold GraphPad Prism hospitalized COVID-19 patient hospitalized COVID-19 patients IFN IFN-γ IGRA increase Increased independent predictor indeterminate lymphopenia median multivariable analysis non-survivor Non-survivors oxygen supply Patient patients patients hospitalized peripheral Peripheral blood positive correlation Prevalence Production QuantiFERON-TB Gold Rate Reflecting required Retrospective study SARS-CoV-2 severe cases severe COVID-19 patient stratified survivor T-cell T-lymphocyte to define was performed [DOI] 10.3390/life12020244 PMC 바로가기 [Article Type] Article
Transmitted Fetal Immune Response in Cases of SARS-CoV-2 Infections during PregnancyArticle Published on 2022-01-192022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] age analyzed anti-SARS-CoV-2 antibodies CD3 CD3+ CD34 CD4 CD8 cell count cellular immunity change Concentration concentrations correlation COVID-19 and pregnancy diagnosis of SARS-CoV-2 Effect fetal fetal immune system fetal lymphocyte subsets humoral IFN-γ IgG IgG and IgM IgM antibody IL6 immune response Immunity Infection Inflammatory response information iNKT interleukin interleukin 6 mononuclear cell Newborn Placenta placental Placentas Pregnancy pregnant women recruited Research response RNA SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection significantly higher study period subset T cell the SARS-CoV-2 virus transfer transmitted umbilical cord blood undetectable Viral RNA [DOI] 10.3390/diagnostics12020245 PMC 바로가기 [Article Type] Article
Innate and Adaptive Immunity Imbalance With Severe COVID-19 Pneumonia in Children and AdultsPediatrics Published on 2021-12-152022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Abnormalities adaptive adaptive immune cells Admission Adult patient Adult patients Adults alteration analyzed CD14+ monocyte CD3+ CD4+ T cell CD8+ T cell Characteristics Chest CT children clinical complication clinical manifestation Clinical symptoms Comorbidities Control controls coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical enrolled Frequency had more healthy Imbalance immune Immune cell immune response alteration Inflammatory response Innate Innate immune cells Laboratory laboratory abnormalities Laboratory features lymphocyte Mild much higher Patient patients pilot study Pneumonia Prevalence radiological real-time RT-PCR recruited SARS-CoV-2 severe patients significantly lower subpopulations subset survived T-lymphocyte with COVID-19 [DOI] 10.3389/fped.2021.736013 PMC 바로가기 [Article Type] Pediatrics