CD4 – Page 2 – Communicable Diseases Research

Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV

Article

Published on 2022-11-012022-11-15
Journal: Clinical microbiology and infection : the official
[Category] COVID19(2023년), SARS, 진단,

Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19

Article

Published on 2022-11-012022-11-15
Journal: The Pediatric Infectious Disease Journal
[Category] SARS, 진단, 치료기술,

[키워드] Absolute lymphocyte count activated acute phase acute respiratory syndrome Anti-inflammatory Antibody Response CD3 CD4 CD8 Cell children children with COVID-19 Clinical outcome clinical presentation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine profile decrease dependent on disease severity distress effector memory exhibited groups help HLADR IL-1ra IL-1β immune mechanism Immune phenotype Immune profile increase in Infection Inflammatory Laboratory parameters Mild MIS-C no difference not significantly different Patient pediatric profile prospective cohort study RANTES SARS-CoV-2 IgG SARS-CoV2 sera severe disease severity syndrome T cell T cells tumor necrosis factor-α was performed with COVID-19
[DOI] 10.1097/INF.0000000000003669 PMC 바로가기

Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19

Article

Published on 2022-11-012022-11-15
Journal: International immunopharmacology
[Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome anti-inflammatory cytokine CD4 CD8 Cell Cell-based therapy conserved Conserved T cell epitope Coronavirinae coronavirus coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 in patients current epitope global public health help highlight Human identification Immunity infect Infection Inflammatory monoclonal antibody mutant new SARS-CoV-2 omicron outbreak pandemic PROTECT Protein RdRP restrict RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants secreted Seven specificity T cell T cells targeted epitope TCR TCR-T therapy. therapy transducing Treatment unique Vaccine variant variants
[DOI] 10.1016/j.intimp.2022.109283 PMC 바로가기

Spike-specific T-cell responses in patients with COVID-19 successfully treated with neutralizing monoclonal antibodies against SARS-CoV-2

Article

Published on 2022-11-012022-11-15
Journal: International Journal of Infectious Diseases
[Category] SARS, 진단,

[키워드] Administered analyzed CD4 CD8 cellular response Clinical outcome COVID-19 demonstrated effective evaluate Evolution flow cytometric group healthy controls immune memory Immunity Impact impair IMPROVE increases in individuals Infection initial investigated marker median memory memory T-cell response monoclonal antibodies monoclonal antibody neutralizing monoclonal antibody Patient patients patients treated patients with COVID-19 receiving SARS-CoV-2 significant increases in SOT spike statistically significant statistically significant difference T-cell Response T-cell response. treated Treatment Viral diseases were measured
[DOI] 10.1016/j.ijid.2022.09.016 PMC 바로가기

Association of Interleukin-17F Polymorphism and Mortality Predictors with the Risk of COVID-19

Article

Published on 2022-10-272022-11-15
Journal: International journal of clinical practice
[Category] 변종, 진단,

[키워드] age allele Analysis association AUC case-control study CD4 cells Characteristics control subject controls Coronavirus disease-19 COVID-19 COVID-19 infection COVID-19 mortality COVID-19 patient COVID-19 patients cutoff point D-dimer death determine enzyme-linked immunosorbent exhibiting expression Genotype genotyping healthy higher odd hypertension IL-17 immunological injuries in-hospital mortality independent predictor investigated Laboratory no significant difference non-survivor outcome participant polymorphism predictor proinflammatory risk of COVID-19 ROC Curve subset suggested survivor susceptibility T lymphocytes tested variant WBC White blood cell with COVID-19
[DOI] 10.1155/2022/4761631 PMC 바로가기

Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

Article

Published on 2022-10-132022-11-15
Journal: eLife
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] Activation acute respiratory syndrome antibody approved blood sample Brazil CD4 cellular Chilean China circulating antibodies clinical clinical trial Concentration CoronaVac coronavirus coronavirus disease correlation COVID-19 difference dose Efficacy elicited Emergency use enrolled evaluate evaluated exhibited expression flow cytometry healthy Human humoral immune response humoral immune responses IFN-γ immune response immunization immunogenicity data immunology inactivated Indonesia Inflammation interferon marker Medicine Ministry of Health mononuclear cell multicenter neutralizing antibody neutralizing capacity pandemic PBMCs performed Peripheral blood Phase 3 phase 3 clinical trial phase 3 trial Production progression promote Randomized reported robust Sample SARS-CoV-2 SARS-CoV-2 vaccine secretion separated single center Stimulation T cell Trial Turkey Vaccine Vaccines Vaccines. variants of concern virus VOCs Volunteer were assessed
[DOI] 10.7554/eLife.81477 PMC 바로가기

Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 Treatment

Article

Published on 2022-10-122022-11-15
Journal: Neurology® neuroimmunology & neuroinflammation
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단,

[키워드] acute respiratory syndrome Analysis analyzed anti-SARS-CoV-2 antibody Antibody Response association Blood CD19 CD3 CD4 CD8 CD8 T cell CD8 T-cell response cellular center clinical decision Cohort collected conducted coronavirus coronavirus disease correlated cross-sectional Defense evaluate Germany humoral immune response Humoral response immune response Immunoglobulin Infection interferon-γ interval lymphocyte counts matter Multiple multiple sclerosis Patient peptide pools receiving regulated response responses Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination sclerosis significantly increased Spike protein Status post subpopulation T cell T-cell the timing Treatment vaccination vaccination response Vaccination strategy variants of concern were measured
[DOI] 10.1212/NXI.0000000000200031 PMC 바로가기

Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccines

Article

Published on 2022-10-112022-11-15
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 진단,

[키워드] acute respiratory syndrome adverse outcome Alpha Anti-RBD IgG BNT162b2 CD4 CD8 cell-mediated immune response cellular Clinical outcome comparable CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 vaccine COVID-19 vaccines diabete dose Effectiveness evaluated first dose healthy individual humoral immune response IgG antibody immune dysfunction Immunological memory immunological memory response Immunological response inactivated Infection influence initial memory mRNA neutralizing antibody neutralizing capacity of BNT162b2 Part Patient platform potential mechanism protective immunity RBD receiving Receptor binding domain reduction in resulting SARS-CoV2 second dose sera susceptibility T cell response T cells T2D Th1 titre Type type 2 diabete type 2 diabetes type 2 diabetes. vaccination vaccinee Vaccines
[DOI] 10.3389/fimmu.2022.1018393 PMC 바로가기

The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

Article

Published on 2022-10-112022-11-15
Journal: Immunity
[Category] COVID19(2023년), SARS, 진단,

Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 study

Article

Published on 2022-10-102022-11-15
Journal: Respiratory Research
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2. severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed
[DOI] 10.1186/s12931-022-02190-8 PMC 바로가기