Evaluation of the Levels of Peripheral CD3 + , CD4 + , and CD8 + T Cells and IgG and IgM Antibodies in COVID-19 Patients at Different Stages of Infection감염 단계에서 COVID-19 환자에서 말초 CD3 +, CD4 + 및 CD8 + T 세포 및 IgG 및 IgM 항체의 수준의 평가Research Article Published on 2022-02-232022-08-31 Journal: Microbiology Spectrum [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect antibody production association Blood CD3 CD4 CD45 CD8 Cell Cell-mediated immunity Cellular immune response cellular immune responses cellular immunity changes in China clinical sample clinical samples collected conducted coronavirus COVID-19 cytometry analysis determine died ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Flow flow cytometry Flow cytometry analysis groups healthy individual help Hospitalized IgG IgG and IgM IgM IgM and IgG immune responses immune system Immunity infected with SARS-CoV-2 Infection Level levels of antibodies levels of antibody lymphopenia main role medication moderate Patient patients patients with moderate peripheral Peripheral blood peripheral blood samples recovered patients reduction in reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient SARS-CoV-2-infected patients serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 shown significant increase significantly Stage stimulatory Support T cell T cells Vaccine virus was performed were used [DOI] 10.1128/spectrum.00845-21 PMC 바로가기 [Article Type] Research Article
An In Vivo Observational Histological Study of Peripheral Arterial Damage in Patients with Acute Limb Ischemia in SARS-CoV-2 InfectionArticle Published on 2022-02-142022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] active smokers Acute limb ischemia Analysis analyzed arterial Arterial hypertension CD45 CD68 change damage Diabetes Mellitus endothelial Endothelial dysfunction events Evidence histologic histological histopathological immunohistochemistry in vivo Inflammation intraarterial investigated Ischemia lack limb mechanism obese Patient patients patients with COVID-19 performed peripheral prothrombotic Reactions reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients skeletal muscles structures suffered Thrombus thrombus formation tissue [DOI] 10.3390/diagnostics12020488 PMC 바로가기 [Article Type] Article
Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38 + macrophages and NAD + declineArticle Published on 2022-01-272022-10-04 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] addition age Bone marrow BPIFB4 cardiovascular disease CD38 CD45 Cell change characterized chronic inflammation clinical implication consequence contributing to CVD Deleterious described disorders driving event exceptional frailty Frequency functional Gal Haplotype healthy IL10 IL1β IL6 immune Immune cell immune system Immunological disorders in vivo increase in Inflammation Inflammatory diseases Macrophage mice morbidity and mortality offer pathophysiological Peripheral blood phenotype plasma Prevent previous study pro-inflammatory monocyte progression reduce reduced reduction reduction in senescence senescent shown spleen sustained systemic inflammation therapeutic therapeutic target tissue-resident macrophage transfer treated variant vasculature [DOI] 10.1038/s41419-022-04535-z PMC 바로가기 [Article Type] Article
Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in miceRAGE 신호 전달 장애는 생쥐에서 SARS-CoV-2 감염 후 생존을 촉진하고 질병 발병을 제한합니다Research Article Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 유전자 메커니즘, 진단, [키워드] CD45 Cell cell death Cellular and molecular mechanisms contribute Critical defined disease pathogenesis driving Efficacy end products endothelial event hyperplasia immunology IMPROVE Infection Infectious disease Inflammation initiated Innate immunity interstitial pneumonia limit lung Lung injury Lungs mediator metabolic mice molecular molecular mechanism morbidity mouse model necrotic necrotic cell death outcome oxygen oxygen saturation Pathogenesis pathology perivascular perivascular inflammation populations promote RAGE receptor receptor for advanced glycation end products replicated SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection Signaling survival therapeutic target Therapeutic treatment tissue injury Treatment triggering Viral viral loads [DOI] 10.1172/jci.insight.155896 PMC 바로가기 [Article Type] Research Article
Longitudinal Trend of Plasma Concentrations of Extracellular Vesicles in Patients Hospitalized for COVID-19Cell and Developmental Biology Published on 2022-01-172022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 activated acute phase Admission age Analysis analyzed Angiotensin-converting enzyme association baseline blood sample CD45 CD45+ Cell cellular activation Clinical outcome Coagulopathy collected Concentration COVID-19 COVID-19 patient discharge evaluated EVs expressing extracellular vesicle flow cytometry growth factor hypercoaguability Inflammation involved longitudinal male Microvesicles Patient pericyte persist plasma concentration Platelet PPL recruited SARS–CoV–2 sensitivity significantly Symptom thrombosis tissue trend unit venous thomboembolism [DOI] 10.3389/fcell.2021.770463 PMC 바로가기 [Article Type] Cell and Developmental Biology
Merkel cell carcinoma presenting as a malignant pleural effusion post-COVID-19 hospitalization: A case report and literature review코로나19 입원 후 악성 흉막삼출액으로 나타난 메르켈세포암: 증례보고 및 문헌고찰Case Reports Published on 2022-01-012022-09-12 Journal: Diagnostic cytopathology [Category] SARS, 진단, [키워드] Case report CD45 CD56 Cell cells chromatin chromogranin Cluster COVID-19 cytoplasm demonstrated diagnosed English FIVE fluid cytology Hospitalization hyperchromatic nuclei Immunosuppression Immunosuppressive treatment Ki67 knowledge literature review Lymphocytes Macrophage male MCC medium Merkel cell carcinoma Merkel cell polyomavirus neuroendocrine Patient pleural effusion Pneumonia positive presenting proliferative receiving reported Respiratory failure steroid treatment synaptophysin Tocilizumab Tumor UV light was done [DOI] 10.1002/dc.24882 PMC 바로가기 [Article Type] Case Reports
Signature of long-lived memory CD8 + T cells in acute SARS-CoV-2 infection급성 SARS-COV-2 감염에서 장기 기억 CD8 + T 세포의 시그니처Article Published on 2021-12-072022-08-31 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerated acute infection acute SARS-CoV-2 infection acute viral infection adaptive Adaptive immunity Blood CCR7 CD45 CD45RA CD8 cells cellular characterized circulating clone clones COVID-19 pandemic effector memory evidence of Express facilitate flow cytometry hallmark IL-7 immune response Immunity Immunological memory Infection interferon low expression maintain memory memory T cell memory T cells outbreak pathogen patients with COVID-19 precursor precursors proliferation question Rapamycin Re-infection SARS-COV-2 infection SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells Sequencing signature stimulated T cell T cell receptor T cells transcriptional Transcriptome transcriptomes Viral viral infection [DOI] 10.1038/s41586-021-04280-x PMC 바로가기 [Article Type] Article
Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia혈액 섬유 세포는 COVID-19 폐렴의 중증도 및 예후와 관련이 있습니다.Clinical Trial Published on 2021-11-012022-08-31 Journal: American journal of physiology. Lung cellular and [Category] MERS, SARS, 바이오마커, 임상, [키워드] BAL Blood Bronchoalveolar lavage CCL2 CD34 CD45 Cell circulating collagen Complete Computed tomography Concentration Control coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia CXCL12 death determine died FGF2 fibrocyte flow cytometry growth growth factor healthy controls Hospitalized hospitalized patients ICU ICU patient ICU Patients Increased increased risk individual intensive care intensive care unit lung Lung CT Lung diseases median median age Patient patients hospitalized Pneumonia poor prognosis Predictive Prognosis quantified severity and prognosis subgroup of patient survivor TGF-β1 the patient transforming growth factor were measured [DOI] 10.1152/ajplung.00105.2021 PMC 바로가기 [Article Type] Clinical Trial
Imbalanced Immune Response of T-Cell and B-Cell Subsets in Patients with Moderate and Severe COVID-19중등도 및 중증 COVID-19 환자에서 T- 세포 및 B- 세포 서브 세트의 불균형 면역 반응Article Published on 2021-09-302022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] acute COVID-19 analyzed B cell B cells B-cell B-cell subsets both groups Ccr6 CD27 CD38 CD45 CD45RA Cell circulating COVID-19 COVID-19 patients CRP dysregulated enrolled flow cytometry follicular Frequency group healthy donor humoral immune response Imbalance imbalanced immune response immunological change immunological changes Infection memory minute moderate multicolor flow cytometry oxygen Oxygen therapy PaO Patient phenotype Phenotypes predominant qSOFA reduced respiratory rate response severe COVID-19 significantly skewed SpO2 subset T-cell subsets Tfh Th cells Th17 with COVID-19 [DOI] 10.3390/v13101966 PMC 바로가기 [Article Type] Article
Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas림프종의 분리 된 경우에서 SARS-COV-2에 의한 희귀 항 종양 면역 반응의 잠재적 분자 메커니즘Article Published on 2021-09-252022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, [키워드] anti-tumor immune response anti-tumor immunotherapy Apoptosis approach B-cell binding binding site Cancer CD27 CD45 cell proliferation classical Complete Complete Remission complex component domain Extracellular follicular Follicular lymphoma gamma-tubulin ring complex Hodgkin lymphoma induce inhibit initial interact interacting residues internalization Isolated lymphoma lymphoproliferative disorders M pro M protein membrane microtubule molecular mechanism monoclonal antibodies monoclonal antibody motif NF-kB nivolumab nsp10 Nsp7 oncogenesis ORF3a ORF3a protein PD-1 Pembrolizumab Potential Protein Proteins receptor Remission reported response responsible SARS-CoV-2 SARS-COV-2 infection Signaling the SARS-CoV-2 therapeutic potential TRADD TUBG1 virus [DOI] 10.3390/v13101927 PMC 바로가기 [Article Type] Article