SARS-CoV-2 specific plasma cells acquire long-lived phenotypes in human bone marrowarticle Published on 2023-08-082024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] CD19 CD45 human bone marrow Humoral memory long-lived plasma cell SARS-CoV-2 [DOI] 10.1016/j.ebiom.2023.104735 PMC 바로가기 [Article Type] article
Massive macroglossia, a rare side effect of COVID-19: clinical, histologic, and genomic findings in COVID-19-positive versus COVID-19-negative patientsArticle Published on 2022-12-012022-11-16 Journal: Oral and maxillofacial surgery [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] African Analysis CD45 COVID-19 Genetic Genetic predisposition Genetic testing genomic histologic histology Histopathology identify IHC immune cells immune response immunohistochemistry include Inconclusive individual infected with SARS-CoV-2 Intubated massive oral oral pathology oral surgery Oral surgery. organ Patient persistence Result retrospective robust Secondary objective Sequencing Side effect susceptibility tissue samples tissues whole-exome sequencing [DOI] 10.1007/s10006-021-01031-0 PMC 바로가기
Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodiesArticle Published on 2022-09-012022-11-16 Journal: Clinical Cardiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Admission Analysis antibody Anticoagulant antiheart antibodies association Atherosclerosis Autoimmune average biopsy proven CD20 CD3 CD45 CD68 characterized chronic chronic heart failure Clinical sign Combination congestive heart failure Coronary coronavirus COVID-19 diagnosed Diagnosis diagnosis of COVID-19 edema Ejection fraction EMB Endocarditis Endomyocardial biopsy Endothelium eosinophilic myocarditis heart IgG IHC immune infective lymphocytic myocarditis Macrophage male mechanism Morphological Myocardial myocarditis New York nine nucleocapsid antigens Patient patients persistence polymerase chain post-COVID endocarditis post-COVID myocarditis RNA SARS-CoV-2 Seroconversion Symptom therapy thrombosis Treatment ventricular viral infection viral persistence was obtained [DOI] 10.1002/clc.23886 PMC 바로가기
Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on ErythropoiesisArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] SARS, 변종, [키워드] ACE2 Affect Blood blood circulation Bone marrow CD45 CD8 Cell COVID-19 patient COVID-19 patients degranulation Delta disease severity dominant erythropoiesis erythropoiesis. Express expressing expression Frequency function functions granzyme hallmark Hematopoiesis hypoxia immature immunosuppressive immunosuppressive properties Impact impair in vitro investigated omicron oxygen Patient prevalent provide RBC RBCs reactive oxygen specy receptor red blood cell reversed ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly strain subpopulation suppress T cell the SARS-CoV-2 these cell tissues TMPRSS2 Transmissibility variant variants Wuhan Wuhan strain [DOI] 10.1128/spectrum.01730-22 PMC 바로가기
The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency공통 가변성 면역 결핍증에서 2개의 ChAdOx1 nCoV-19 후 BNT162b2 부스팅에 의해 유도된 특정 항체 및 T-세포 반응Article Published on 2022-06-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 immunoglobulin Anti-spike antibody autologous BNT162b2 BNT162b2 vaccine booster vaccination CD19 CD19+ CD3+ CD3+CD4+ CD3+CD8+ CD4+ CD45 CD45+ CD8+ Cell cell count cell counts cell-mediated response ChAdOx1 ChAdOx1 nCoV-19 changes in common common variable immunodeficiency common variable immunodeficiency (CVID) Control Coronavirus-2 COVID-19 infection cumulative cut-off value CVID decrease ELISPOT ELISpot assay evaluated except for flow cytometric healthy control healthy controls healthy individual healthy individuals humoral IFN-γ IFN-γ ELISPOT IFN-γ ELISpot assay IFN-γ producing T cells immune response immunodeficiency Immunoglobulin Immunoglobulin G immunosuppressive immunosuppressive therapy individual interferon interferon-γ Killer cell less Lymphocytes measure morbidity natural killer natural killer cell not different not significant Patient patients positive Primary Immunodeficiency producing protein S raised receiving response Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown Side effects significant difference significant differences significantly significantly lower Specific statistically stem cell Stem cell transplantation T cell T cell response T cells tested therapy These data vaccination Vaccinations variable virus-specific T cell virus-specific T-cell with COVID-19 [DOI] 10.3389/fimmu.2022.907125 PMC 바로가기 [Article Type] Article
High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4 + T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19장기간의 COVID-19가 있는 항-CD20 치료를 받은 환자에서 높고 지속되는 생체외 빈도이지만 SARS-CoV-2-특이적 CD4 + T-세포의 변경된 표현형Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] abrogate Altered Analysis anti-CD20 anti-CD20 therapy anti-CD20 therapy. B-cell CD39 CD4 CD4+ CD4+ T-cells CD45 CD45RA CD73 Cell circulating COVID-19 CRP CXCR5 effector cells epitope Ex vivo expression follicular Frequency help helper cell IL-6 Infection inflammation marker Interaction lack LAG-3 membrane protein memory MHC class MHC class II MHC class II Tetramer Patient patients PD-1 phenotype Prolonged receptor reduced robust SARS-CoV-2 skewed T follicular helper cell T-cell T-cell memory T-cell Response T-cells tetramer the patient TIGIT viral replication [DOI] 10.3390/v14061265 PMC 바로가기 [Article Type] Article
Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection폐 공간 프로파일링은 치명적인 SARS-CoV-2 감염이 있는 COPD 환자의 T 세포 서명을 나타냅니다Article Published on 2022-06-072022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] airways Antigen CD4 CD45 CD45RO Cell characterized chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) chronic obstructive pulmonary disease (COPD). COPD COVID-19 COVID-19 infection death died downregulation expression Gene Expression immune microenvironment immune response invasive lung Lung disease Lung diseases lung parenchyma memory memory T memory T cell obstructive pulmonary disease parenchyma Patient patients priming Profiling Protein proteomic pulmonary disease receptor ROI ROIs SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 disease 2019 SARS-CoV-2 entry SARS-COV-2 infection sick signature significant enrichment Smokers Still structural gene T cell T cell response T cells T-lymphocyte T-lymphocytes transcriptomic underlie vessel vessels with COVID-19 [DOI] 10.3390/cells11121864 PMC 바로가기 [Article Type] Article
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infectionCOVID-19 혈청에 의해 유도된 체외 NET-osis는 백신 접종을 하지 않은 환자의 심각한 임상 경과 및 돌발성 감염의 면역 조절 장애와 관련이 있습니다.Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] ACE Activation affected age approach Breakthrough infection breakthrough infections CD14 CD16 CD3 CD4 CD4+ CD45 CD45RA CD45RO CD64 CD8 CD8+ Cell cells characterized circulating cytokine circulating cytokines classical Clinical course Clinical features complex Concentration controls COVID-19 COVID-19 infections COVID-19 patient COVID-19 patients COVID-19 sera COVID-19 treatment cytokine Cytokines Cytometry disease disease severity dysregulation effector cells expansion healthy healthy donors healthy subject healthy subjects highlight Hospital admission IFN-γ IL-17A IL-1β IL-6 immune Immune cell immune cells immune dysregulation immune response In-vitro inhibitor Inpatients Major marker memory B-cell Mild Mild disease moderate Monocytes myeloid naïve NET NETosis NETs neutrophil Neutrophil extracellular trap overexpressing Patient patients percentage Peripheral blood pilot study ramipril reduced reduction risk sera severe COVID-19 patient Sex T cell T cells T-cell T-cells Treatment viral clearance [DOI] 10.1038/s41598-022-11157-0 PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signalingSARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1 [DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article