CD8
[대역어] CD8
[용어속성] Protein
[용어속성] Protein
Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3
Article
[키워드] Ablation
addition
affected
Antigen
CD8
CD8+ T cell
changes in
convalescent
COVID-19
demonstrated
epitope
genetics
Immunity
immunodominant
less
leukocyte
neutralization
observation
omicron
raised
recognize
reduction in
SARS-CoV-2
sequence
suggested
T cell
T cell response
T cell responses
T cells
the SARS-CoV-2
vaccinated individuals
Vaccine-induced immunity
variant
[DOI] 10.1038/s41467-022-34180-1 PMC 바로가기
[DOI] 10.1038/s41467-022-34180-1 PMC 바로가기
Timing of SARS-CoV-2 Vaccination Matters in People With Multiple Sclerosis on Pulsed Anti-CD20 Treatment
Article
Published on
Journal: Neurology® neuroimmunology & neuroinflammation
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단,
Journal: Neurology® neuroimmunology & neuroinflammation
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단,
[키워드] acute respiratory syndrome
Analysis
analyzed
anti-SARS-CoV-2
antibody
Antibody Response
association
Blood
CD19
CD3
CD4
CD8
CD8 T cell
CD8 T-cell response
cellular
center
clinical decision
Cohort
collected
conducted
coronavirus
coronavirus disease
correlated
cross-sectional
Defense
evaluate
Germany
humoral immune response
Humoral response
immune response
Immunoglobulin
Infection
interferon-γ
interval
lymphocyte counts
matter
Multiple
multiple sclerosis
Patient
peptide pools
receiving
regulated
response
responses
Sample
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike
SARS-CoV-2 vaccination
sclerosis
significantly increased
Spike protein
Status post
subpopulation
T cell
T-cell
the timing
Treatment
vaccination
vaccination response
Vaccination strategy
variants of concern
were measured
[DOI] 10.1212/NXI.0000000000200031 PMC 바로가기
[DOI] 10.1212/NXI.0000000000200031 PMC 바로가기
Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccines
Article
[키워드] acute respiratory syndrome
adverse outcome
Alpha
Anti-RBD IgG
BNT162b2
CD4
CD8
cell-mediated immune response
cellular
Clinical outcome
comparable
CoronaVac
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
COVID-19 vaccine
COVID-19 vaccines
diabete
dose
Effectiveness
evaluated
first dose
healthy individual
humoral immune response
IgG antibody
immune dysfunction
Immunological memory
immunological memory response
Immunological response
inactivated
Infection
influence
initial
memory
mRNA
neutralizing antibody
neutralizing capacity
of BNT162b2
Part
Patient
platform
potential mechanism
protective immunity
RBD
receiving
Receptor binding domain
reduction in
resulting
SARS-CoV2
second dose
sera
susceptibility
T cell response
T cells
T2D
Th1
titre
Type
type 2 diabete
type 2 diabetes
type 2 diabetes.
vaccination
vaccinee
Vaccines
[DOI] 10.3389/fimmu.2022.1018393 PMC 바로가기
[DOI] 10.3389/fimmu.2022.1018393 PMC 바로가기
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins
Article
Published on
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,
[키워드] absence
acute respiratory syndrome
Affect
Amino acid
Antigen
Antigen presentation
biological activity
caused
CD8
Cell
complex
Coronavirus-2
Cytotoxic T cells
dissemination
down-regulation
downregulating
Endoplasmic reticulum
expressed
histocompatibility complex
human populations
immune responses
Immunity
induce
infected with SARS-CoV-2
Infection
inhibited
inhibition
mechanism
MHC-I
MHC-I down-regulation
ORF7a
orf7a protein
peptide
Peptide loading complex
persistence
physically
prevented
reduced
sarbecovirus
sarbecovirus
Sarbecovirus.
SARS-CoV
SARS-CoV-2
T cells
variety
viral peptide
Viral proteins
[DOI] 10.1073/pnas.2209042119 PMC 바로가기
[DOI] 10.1073/pnas.2209042119 PMC 바로가기
Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 study
Article
[키워드] acute phase
addition
affected
Analysis
biological marker
CD3+ cells
CD4
CD8
Cell
cell population
central memory
Central memory T cells
control group
control patient
controls
COVID-19
COVID-19 diagnosis
cross-sectional
decrease
described
differential expression
disease
early phase
effector
effector memory
Effector memory T cells
flow cytometry
group
homeostasis
hospital
Hospital admission
immune
increase
interstitial
interstitial lung involvement
interstitial pneumonia
lymphocyte subpopulation
Lymphocyte subpopulations
memory
memory T
memory T cells
Patient
patients with pneumonia
performed
Peripheral blood
peripheral lymphocyte
Pneumonia
positive
pre-existing T-cell
protocol
reactivity
recruited
Research
Respiratory disease
SARS-CoV-2
SARS-CoV-2 PCR
SARS-CoV-2.
severe COVID-19 patients
significant decrease
significant increase
study participant
study period
subpopulations
subset
T cell
T-cell
therapeutic
viral respiratory infections
were assessed
[DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
[DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
Article
[키워드] 100% conserved
Analysis
Antigen
Beta
caused
CD4
CD4+
CD8
CD8+ T cell
clade
clades
composed
confirmed cases
conserved
COVID-19
cross-protective
deaths
Delta
epitope
Epitopes
Epsilon
Eta
Gamma
Genome
genomes
GISAID
greater
highly antigenic
HLA binding
hydrophobic
IFN-γ
IL-10
IL-12
IL-2
IL-6
immune response
immune responses
immunoinformatics
in silico approaches
in vivo
Lambda
long-lasting
majority
memory
Metadata
molecular docking
Mortality
Mutation
non-toxic
offer
omicron
ORF
ORF1ab
ORF8 proteins
peptide
performed
promoted
Protein
reduced
Reinfection
SARS-CoV-2
SARS-CoV-2 genome
SARS-CoV-2 variants
secretion
severity
Strains
suffered
T cell epitope
TGF-β
Th1
the Spike
the vaccine
TLR4
Vaccine
variant
variants
virus
virus transmission
WHO
Wuhan
[DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
[DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccination
Article
[키워드] acute respiratory syndrome
analyzed
antibody
CD4
CD4+
CD4+ T cells
CD8
CD8+
CD8+ T cells
Cellular immune response
competent
coronavirus
COVID-19
COVID-19 vaccination
develop
dose
elicited
ELISPOT
exhibited
had no
healthy individuals
humoral
ICU
immune protection
immune response
individual
individuals
information
intensive care
intensive care unit workers
lack
maintain
mRNA
mRNA COVID-19 vaccines
mRNA vaccine
neutralizing antibody
proportion
Protein
protein S
reactive
receiving
reduction in
SARS-CoV-2
SARS-CoV-2-specific T cell
Seroconversion
seronegative
Specific T-cell response
susceptibility
T cell
T cell response
T cells
T lymphocyte
T-cell
the S protein
the SARS-CoV-2
the spike protein
vaccination
vaccination.
viral infection
Viral protein
[DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
[DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
Individuals with obesity who survive SARS-CoV-2 infection have preserved antigen-specific T cell frequencies
Article
[키워드] Admission
CD4
CD8
Cohort
comparable
COVID-19
cytokine response
flow cytometry
Frequency
generate
hepatitis B
Hospitalization
IFNγ
IgG antibody titer
immune dysregulation
immune memory
Immunity
individual
individuals
Influenza
intensive care
investigated
membrane
Mortality
Neutralizing
obesity
Patient
peptide pool
preserved
reduced
reported
response
risk factor
robust
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike
severe disease
T cell
T cell response
T cell subset
T cells
TNFα
vaccination
weakened
[DOI] 10.1002/oby.23526 PMC 바로가기
[DOI] 10.1002/oby.23526 PMC 바로가기
Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations
Article
[키워드] Autopsy
Brain
calculated
case sery
CD8
Cell
Central nervous system
clinical
clinical manifestation
clinical manifestations
correlated
correlation
COVID-19
described
Encephalopathy
fatal COVID-19
FIVE
highest
hospitalisation
hypoxic
IL-6
illness duration
intensive care
lesion
lesions
macrophage activation syndrome
microglial
microthrombi
Neuroinflammation
neurological
Neurological symptoms
neuropathology.
no correlation
one patient
onset of symptoms
parameter
pathology
Patient
patients
performed
Pituitary
proportion
qRT-PCR
quantification
retrospective
SARS-CoV-2 RNA
severe COVID-19 patient
systemic inflammation
T-cell activation
Two patient
Vascular
[DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기
[DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기