SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis
SARS-CoV-2 스파이크 단백질은 미세혈관 항상성을 불안정하게 합니다.
Research Article
[키워드] ACE2
ACE2 expression
Activation
adverse effect
adverse effects
Affect
alveolar
alveolar epithelial cell
Analysis
angiotensin
angiotensin converting enzyme
angiotensin converting enzyme 2
Angiotensin II
Apoptosis
Aspirin
bind
blunt
bradykinin
calcium
Calcium signaling
caspase
cause
caused
Cell
Cell signaling
cells
Coagulopathies
complex
Concentration
contribute
contributing to
COVID-19
COVID-19 disease
decreased expression
downregulation
dysfunction
Effect
Endothelial cell
endothelial cells
Endothelial dysfunction
enzymatic activity
enzyme
epithelial
epithelial cells
event
Evidence
exposure
expressed
Factor
homeostasis
immunofluorescence microscopy
in vitro model
increased expression
indicated
infects
Inflammation
Interaction
Interference
Intervention
Krüppel
limit
lung
lung tissue
lung tissues
Lungs
mechanism
molecules
organ dysfunction
Pathogenesis
pathology
primary human cells
pro-inflammatory molecules
rationale
receptor
reduce
reduced
Respiratory function
SARS-CoV-2
SARS-CoV-2 infected individuals
SARS-COV-2 infection
Signaling
significantly
spike
Spike protein
suggested
tested
these cell
These cells
thought
thrombotic
Thrombotic events
understanding
uninfected
Vascular
viability
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article