ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19지방 조직에서의 ACE2 발현은 코로나19에 대한 심장 대사 위험 인자 및 세포 유형 구성과 관련이 있습니다.Meta-Analysis Published on 2022-08-012022-09-11 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 expression adipose Adipose tissue age angiotensin angiotensin I angiotensin I converting enzyme 2 BMI Cell cell type cell types cellular entry contribute COVID-19 COVID-19 severity diabetes Diseases distal Endothelial cell enzyme eQTLs expression Factor Factors fasting insulin feature Genetic HDL Health identify increased risk independent individual insulin investigated loci Lower lower expression Macrophage macrophages Meta-analysis obesity participant pathophysiology phenotypic proportion proximal Quantitative receptor risk risk factor RNA-Seq SARS-CoV-2 serum severe COVID-19 T2D tissue tissue expression type 2 diabete type 2 diabetes [DOI] 10.1038/s41366-022-01136-w PMC 바로가기 [Article Type] Meta-Analysis
Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infectionSARS-CoV-2 감염 시 인터페론 유도, 회피 및 역설적 역할Review Published on 2022-08-012022-09-11 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alleviate antiviral immunity causative agent caused cell type cell types coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency disease disease severity effort evade function IFN IFN response IFNs immune immune evasion interferon interferon. interferons interferons (IFNs location mechanism outcome paradoxical pathway Pathways Protective Research responses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly supported Therapeutics Treatment treatment of COVID-19 Type type I Type I and III IFN virus while [DOI] 10.1111/imr.13113 PMC 바로가기 [Article Type] Review
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome antioxidant defense system antiviral activity ARDS Biliverdin catalytic domain cell type COVID-19 pandemic Cytokine storms death Defense Evidence Factor Genetic HMOX1 Host host defense inhibit interact mechanism metabolite MOST Nrf2 nsp14 oxidative stress pathway producing regulated respiratory distress Respiratory failure Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 virus significantly SIRT1 SIRT1. sirtuin suppressed syndrome Viral protein [DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic AnalysesSARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력Article Published on 2022-08-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNA. miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability [DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article
COVID-19 Infections in Gonads: Consequences on Fertility?생식선의 COVID-19 감염: 불임에 대한 결과?Review Published on 2022-08-012022-09-12 Journal: Hormone and metabolic research = Hormon- und Stoff [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 addition Affect angiotensin-converting enzyme 2 cell type changes in consequence COVID COVID-19 COVID-19 infection COVID-19 pandemic decrease described dysfunction Effect entry pathway example expression healthy impairing include Interaction knowledge men menstrual mental health issue Oocyte ovarian Premature protease Psychological reduced reported SARS-CoV-2 SARS-CoV-2 vaccine Serine Sexuality Stress tissue TMPRSS2 transmembrane women [DOI] 10.1055/a-1891-6621 PMC 바로가기 [Article Type] Review
DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndromeDecodeME: 근육통 뇌척수염/만성 피로 증후군의 대규모 유전학 연구를 위한 커뮤니티 모집Article Published on 2022-07-192022-09-11 Journal: BMC Neurology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] aetiology approach association causes cell type cell types cellular processe cellular processes Chronic fatigue chronic fatigue syndrome Clinical diagnosis Co-production Community contributing to controls criteria diagnose Diagnosis diagnostic diagnostic test digital marketing disease DNA effective effective therapy eligible Encephalomyelitis ethics committee fatigue fatigue syndrome funding generate Genes genetic data genetics Genome-wide association study genomic Genotype hypothese hypotheses identification IMPROVE include individuals International intervals Involvement knowledge lack malaise mechanism media myalgic encephalomyelitis North Open Access paper participant Participation Patient and Public Involvement. Public Questionnaires recruitment Relieved by reported Research Ethics Result risk Saliva SARS-COV-2 infection significantly social media Treatment UK biobank variant website West [DOI] 10.1186/s12883-022-02763-6 PMC 바로가기 [Article Type] Article
A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys Research Published on 2022-07-132022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] analysis animal model Cell cell type cellular cellular processes chromatin developmental element feature gene expression pattern gene regulatory network heterogeneity humans identify Laboratory molecular multiple organ multiple tissue Non-human non-human primate organ-specific organs provide RNA sequencing data similarity single-cell single-cell level trajectory transcriptomic transcriptomic data valuable resource [DOI] 10.1038/s41467-022-31770-x [Article Type] Research
Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다Article Published on 2022-07-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19 [DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article
Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children상기도 유전자 발현은 소아에서 SARS-CoV-2에 대한 보다 강력한 적응 면역 반응을 보여줍니다Article Published on 2022-07-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] activated Adaptive immune response airway B cell B cells cause cell type children ciliated cells contribute decrease disease elicit Gene Expression greater groups IFNγ IL-2 IL-4 immune response Infection interferon-stimulated gene interferon-stimulated genes macrophages nasopharyngeal Older Other respiratory viruses pathway Pathways Proinflammatory cytokine proinflammatory cytokine signaling proportion proportions recruitment respiratory viruses robust SARS-CoV-2 SARS-COV-2 infection severe disease T cell T cell activation target TNF upper airway upregulation virus [DOI] 10.1038/s41467-022-31600-0 PMC 바로가기 [Article Type] Article
Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway선천성 면역을 위한 핵심 세포 유형으로서의 내피 세포: RIG-I 신호 전달 경로에 대한 집중 검토Review Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] 치료법, [키워드] Activation anti-viral response Atherosclerosis Bacteria Bacterial bacterial and viral infections bloodstream cardiovascular disease cardiovascular diseases caused Cell cell type close contact contact with COVID-19 danger signals DDX58 demonstrated disorder disorders dsDNA dsRNA endothelial Endothelial cell endothelial cells Endothelial dysfunction Evidence expression function heterogeneous highlight host antiviral response immune immune functions immune surveillance Immunity Infectious disease Inflammation Inflammation. inhibited Innate Innate immunity interferons invading pathogen Ligand Like LPS macrophages microbial infection Panax notoginseng pathogen Pathogens PPARγ provided PRR recent receptor retinoic acid review RIG-I saponins shown signal signaling pathway Surveillance translational Type Vascular endothelium viral infection viral infections virus virus virus infection [DOI] 10.3389/fimmu.2022.951614 PMC 바로가기 [Article Type] Review