Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusionArticle Published on 2022-11-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2-expressing cells acute respiratory syndrome alleviate Antiviral binding blocked Broad-spectrum antiviral against SARS-CoV-2 caused Cell Cell fusion cell lines cell-free virus cells characteristic coronavirus Delta determine Diseases downregulation Effect evaluated examined flow cytometry fluorescence microscopy fluorescent Fungal immunomodulatory proteins fusion GMI HEK293T cell host cell immunomodulatory immunoprecipitation in vitro Infection Infectivity ingredient inhibit inhibited inhibitor Interaction investigated less mechanism multifunctional omicron Protein pseudotyped virus reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein SARS-CoV-2 variant spike mutation spike variant spike variants Strains Viral binding. virus were used [DOI] 10.1016/j.biopha.2022.113766 PMC 바로가기
Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid Thyroid. tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic roleArticle Published on 2022-11-012022-11-16 Journal: Journal of microbiology (Seoul, Korea) [Category] B형 간염, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] addition Arm association CAI calculated cells codon adaptation index codon adaptation index (CAI) codon usage correlation evolutionary arms race expressed gene gene expression profile HAV HBV HCC HCV Hepatitis hepatitis viruses Hepatocellular carcinoma hepatocellular carcinoma (HCC) highest Host human genes human tissues initial liver liver cell Lungs oncogenesis oncogenic Perspective relative synonymous codon usage (RSCU). Replication RNA SARS-CoV-2 synonymous translation tRNA Viral proteins Viral RNA virus virus viruses [DOI] 10.1007/s12275-022-2371-x PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
Association of Interleukin-17F Polymorphism and Mortality Predictors with the Risk of COVID-19Article Published on 2022-10-272022-11-15 Journal: International journal of clinical practice [Category] 변종, 진단, [키워드] age allele Analysis association AUC case-control study CD4 cells Characteristics control subject controls Coronavirus disease-19 COVID-19 COVID-19 infection COVID-19 mortality COVID-19 patient COVID-19 patients cutoff point D-dimer death determine enzyme-linked immunosorbent exhibiting expression Genotype genotyping healthy higher odd hypertension IL-17 immunological injuries in-hospital mortality independent predictor investigated Laboratory no significant difference non-survivor outcome participant polymorphism predictor proinflammatory risk of COVID-19 ROC Curve subset suggested survivor susceptibility T lymphocytes tested variant WBC White blood cell with COVID-19 [DOI] 10.1155/2022/4761631 PMC 바로가기
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster modelsArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Administered assigned caused Cell cells changes in close contact complication of COVID-19 Contact days post infection detectable examined group groups hamster highest immature Impact impairment indicated Infection Lineage lung lung damage lung; nose occurred olfactory Olfactory epithelium olfactory receptor cells ORN ORNs pathogenesis of COVID-19 patients with COVID-19 receptor SARS-CoV-2 short-term cohabitation. significantly Spread subsequent tissue tissue damage transmitted uninfected unique Viral load viral presence Viral transmission virus [DOI] 10.3389/fcimb.2022.1019723 PMC 바로가기
Effectiveness of COVID-19 vaccination in healthcare workers in Shiga Prefecture, JapanArticle Published on 2022-10-212022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Abbott analyzed antibody Cell cells Cellular immune response cellular immunity conducted coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccinations Delta effective evaluated HCW HCWs health condition healthcare worker Hospitalization humoral induce Japan Poor questionnaire repeated required Roche SARS-CoV-2 SARS-COV-2 infection serological seropositive Standard deviation vaccination Vaccine Wuhan-1 [DOI] 10.1038/s41598-022-22682-3 PMC 바로가기