Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase InhibitorsArticle Published on 2022-01-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ADME prediction anhydrosugar applied approved atomic average binding pocket carried catalytic Cellulose complex coronavirus correlations COVID-19 docking fluctuation GS-441524 in silico indicated inhibitors of SARS-CoV-2 Interaction metabolite Mitsunobu reaction Modification molecular docking Molecular dynamics simulation molecule nucleoside Nucleoside analogues Potential prediction product pyrolysis RdRP Remdesivir RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV2 Seven supported synthesis these compound Treatment [DOI] 10.3390/ijms23010518 PMC 바로가기 [Article Type] Article
Persimmon-derived tannin has antiviral effects and reduces the severity of infection and transmission of SARS-CoV-2 in a Syrian hamster model감에서 추출한 탄닌은 항바이러스 효과가 있으며 시리아 햄스터 모델에서 SARS-CoV-2의 감염 및 전염의 심각성을 감소시킵니다.Article Published on 2021-12-082022-09-10 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration antioxidant Antiviral effect antiviral effects approach carboxymethyl cellulose caused Cellulose control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Donor dose hamster help human-to-human transmission immunology in vitro in vivo models inoculated investigated Microbiology oral administration oral cavity Persimmon Plaque assay Pneumonia Prevent reduce reduced respiratory Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity Severity of infection Spread suppressed tannin These data Transmission transmission of SARS-CoV-2 transmitted uninfected virus virus titer virus titers [DOI] 10.1038/s41598-021-03149-3 PMC 바로가기 [Article Type] Article
A rapid simple point-of-care assay for the detection of SARS-CoV-2 neutralizing antibodies Research Published on 2021-11-112022-10-05 Journal: Communications Medicine [Category] 바이오마커, [키워드] Accuracy ACE2 antibody approach binding domain can be used cause Cellulose comparable complex convalescent plasma COVID-19 Critical detect detection develop disrupt Efficacy evaluate host cells Human plasma Immunity infecting Interaction MONITOR NAb NAbs pathogen Pathogens point-of-care Prevent pull-down RBD variant Result SARS-CoV-2 SARS-CoV-2 NAb SARS-CoV-2 neutralizing antibody Sensitivity and specificity Vaccine virus [DOI] 10.1038/s43856-021-00045-9 [Article Type] Research
Discrepancies in Infectivity of Flavivirus and SARS-CoV-2 Clinical Samples: An Improved Assay for Infectious Virus Shedding and Viremia Assessment플라비바이러스와 SARS-CoV-2 임상 샘플의 감염력 불일치: 감염성 바이러스 배출 및 바이러스혈증 평가를 위한 개선된 분석Article Published on 2021-09-182022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alternative Antibody titers assessment Avicel Cellulose clinical clinical sample clinical samples coronavirus COVID-19 culture medium Dengue evaluated flavivirus Improved infectious particles Infectivity infectivity assessment Laboratory MCC medium methylcellulose microcrystalline microcrystalline cellulose Neutralizing antibody titer neutralizing antibody titers nucleic acid nucleic acid amplification nucleic acid amplification tests overlay medium Particle plaque Plaque assay plaques respiratory SARS-CoV-2 SARS-CoV-2 strains sensitivity severe acute respiratory syndrome Coronavirus shedding significantly time-consuming Viremia virus virus infectivity virus strains virus titer virus titers Virus titration was performed was used while [DOI] 10.3390/ijerph18189845 PMC 바로가기 [Article Type] Article
Dissolvable sugar barriers to enhance the sensitivity of nitrocellulose membrane lateral flow assay for COVID-19 nucleic acidResearch article Published on 2021-09-012022-10-05 Journal: Carbohydrate polymers [Category] SARS, 치료기술, [키워드] Bio-recognition event Cellulose conditions control line COVID-19 Detection limit diagnostic ENhance HF120 lateral flow Lateral flow assay (LFA) limit many cases membrane NC membrane nitrocellulose Nitrocellulose membrane nucleic acid ORF1ab Pathogens Result sensitivity Sensitivity enhancement sugar test line was used [DOI] 10.1016/j.carbpol.2021.118259 [Article Type] Research article
Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens슈도모나스 단백질 겐에서 표현형 및 유전 적 결과의 예측Research Article Published on 2021-08-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation adaptive addition Air-liquid interface Amino acid Bacterial Biological Biology can not Cancer Cellulose changed Climate change colonize condition conditions conserved core dependent on develop Diseases disrupt Evolution expected experiments Factor fitness followed by Forecasting Genetic Genotype growth hot spot identity Infectious diseases lack majority mathematical mathematical model microbe microbes model system model systems MOST motility mutant mutants Mutation mutation rate Mutation rates mutations negative regulation nucleotide outcome outcomes pathway phenotype Phenotypes phenotypic polysaccharide Population predict predictability predicted predicted gene predicted genes Predictive model prevented problems promoter regions Protein provide Pseudomona Pseudomonas Pseudomonas species Pseudomonas specy real time reduced Region resulting sequence tested Variation [DOI] 10.1371/journal.pgen.1009722 PMC 바로가기 [Article Type] Research Article
Vertical Flow Cellulose-Based Assays for SARS-CoV-2 Antibody Detection in Human Serum인간 혈청에서 SARS-CoV-2 항체 검출을 위한 수직 유동 셀룰로스 기반 분석Article Published on 2021-05-282022-09-11 Journal: ACS Sensors [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antibody test Antigen antigen tests approval capture Cellulose cellulose-binding domain chemiluminescence immunoassay clinical sample clinical samples complement Coronavirus-2 COVID-19 COVID-19 pandemic demonstrated detect detection diminished Emergency use extreme Flow flow rates horseradish peroxidase Human intensity Laboratory Lateral flow test Lateral flow tests membrane nucleic acid paper-based assay peroxidase point of care Rapid replacing reporter respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody test SARS-CoV-2 antigen SARS-CoV-2 antigens sensitivity serological test Serological tests serology seroprevalence survey serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signal intensity supply chains US FDA vertical vertical flow. were used [DOI] 10.1021/acssensors.1c00235 PMC 바로가기 [Article Type] Article
Nanobioengineered Sensing Technologies Based on Cellulose Matrices for Detection of Small Molecules, Macromolecules, and CellsReview Published on 2021-05-242022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] biosensors Cell Cellulose cytosensing described detection develop Diagnosis diagnostics human health Laboratory macromolecules matrix design metal ions Modification molecules nanobioengineering recent reported Small molecules technology trend unique [DOI] 10.3390/bios11060168 PMC 바로가기 [Article Type] Review
Carbohydrate binding module-fused antibodies improve the performance of cellulose-based lateral flow immunoassays탄수화물 결합 모듈 융합 항체는 셀룰로오스 기반 측면 흐름 면역 분석의 성능을 향상시킵니다.Article Published on 2021-04-122022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] antibodies antibody antibody fragment binding Biochemistry Biotechnology carbohydrate Cellulose demonstrated detect detection antibody diagnostics Effect environmental factors food safety implementation IMPROVE Infection lateral flow lateral flow immunoassay Lateral flow immunoassays Lateral flow test Molecular biology nitrocellulose nitrocellulose membranes outbreak pandemic parameters POC Pregnancy Protein Protein binding SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody sensitivity serum specific antibodies sustainability Urine [DOI] 10.1038/s41598-021-87072-7 PMC 바로가기 [Article Type] Article
Dissemination of Aerosol and Splatter in Clinical Environment during Cavity Preparation: An In Vitro StudyArticle Published on 2021-04-042022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] aerosol Anxiety assistant Cavity Cellulose Chest class clinical clinical environment collected college conducted contagious infection Contamination COVID-19 dental dental manikin dental personnel dentistry Environment evaluate Faisal Grade 1 Health care worker infection control investigator King Laboratory operator Particle patients produced Protective reduce replaced risk second set social distancing Splatter Spread statistically significant difference suction the mean the patient tooth university upper leg Volume was done was performed was used were used [DOI] 10.3390/ijerph18073773 PMC 바로가기 [Article Type] Article