Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans박테리아 대사 산물에 의한 화학 감각 뉴런 유전자 발현의 즉각적인 활성화는 Caenorhabditis elegans에서 별개의 순환 GMP 의존 경로에 의해 선택적으로 유도됩니다Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation addition animals Author avoidance bacterial metabolite Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans calcium canonical cGMP chemosensory cyclic GMP dependent on detect dissect dynamic elegan elegans engage expression external environment gene encoding Gene Expression highlighting Immediate induce intracellular signaling lead Ligand mechanism metabolite metabolites microbial modulate nervous system neuroendocrine Neuron neuronal neurons P . aeruginosa pair pathogen pathogenic pathogenic bacteria pathogenic bacterium pathway produced Protective Protein protein kinase Pseudomonas aeruginosa required response selective sensation sensory neuron sensory neurons Signal transduction Signaling signaling pathway subunit TGF-β Transcription transcriptional transcriptional response turn [DOI] 10.1371/journal.pgen.1008505 PMC 바로가기 [Article Type] Research Article
Phosphodiesterase Inhibitors: Could They Be Beneficial for the Treatment of COVID-19?Review Published on 2020-07-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adopted CAMP cellular cGMP China clinical manifestations Clinical sign Combination condition conserved coronavirus COVID-19 Cytokine storm disorder distribution drug drugs effective fibrosis function Health highlighting hydrolyzing enzymes Hypothesis identify Infection Inflammation inhibitor inhibitors knowledge limit measure modulating nucleotide organ outcomes overlapping pan-selective inhibitors pandemic pandemic disease pathology PDE phosphodiesterase Pneumonia post infection reduce SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe complication similarity Spread Support Symptom targets the epidemic thrombosis treated Treatment urgency virus World Health Organization [DOI] 10.3390/ijms21155338 PMC 바로가기 [Article Type] Review
Cyclic nucleotides, gut physiology and inflammationarticle Published on 2020-05-312024-09-01 Journal: The FEBS Journal [Category] 살모넬라증, [키워드] CAMP cGMP cholera toxin Inflammasome receptor guanylyl cyclase C salmonellosis [Article Type] article
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty강력한 이환형 말라리아 cGMP 의존성 단백질 키나제 억제제: 세포 효능, 선택성 및 구조적 참신성의 개선을 결합하는 접근법Article Published on 2019-10-012024-08-26 Journal: Bioorganic & Medicinal Chemistry Letters [Category] 말라리아, [키워드] cGMP Imidazopyridine malaria Plasmodium falciparum Protein kinase G SAR [DOI] 10.1016/j.bmcl.2019.08.014 PMC 바로가기 [Article Type] Article
ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding MotilityArticle Published on 2018-09-102024-08-28 Journal: Current Biology [Category] 말라리아, [키워드] cGMP guanylate cyclase malaria Mosquito motility Ookinete Plasmodium Signal transduction
Plant-derived virus-like particles as vaccinesReview Published on 2013-01-012023-08-30 Journal: Human vaccines & immunotherapeutics [Category] E형 간염, [키워드] cGMP chimeric VLP clinical trial downstream processing glycosylation Oral delivery plant-derived vaccine plant-derived VLP purification Vaccine vaccine platforms virus-like particle (VLP) [DOI] 10.4161/hv.22218 PMC 바로가기 [Article Type] Review