The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting reportarticle Published on 2023-04-202024-09-05 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] update2024, [키워드] cGMP Guanylyl cyclases Mosliciguat Natriuretic peptides nitric oxide NO-GC phosphodiesterases Praliciguat Riociguat Runcaciguat sGC activators sGC stimulators Vericiguat [DOI] 10.1007/s00210-023-02484-8 PMC 바로가기 [Article Type] article
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariantsArticle Published on 2022-08-082022-10-06 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting acute respiratory syndrome Administered administration antibody approved B.1.1.529 breadth cell line cGMP characterized coronavirus COVID-19 CRIPT DARPA defined diagnosed domains Emergency use FDA H2L2 mice Harbor human clinical trials human IgG1 intranasal intranasally intravenous intravenously K18-hACE2 transgenic mice LALA limit lineages Live virus lung titer NAb neutralization assays Neutralizing Neutralizing activity neutralizing antibody omicron Omicron BA.1 Omicron BA.1.1 Omicron BA.2 Pre-clinical research provided pseudotype quantitation reduced required retained SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike subset tested therapeutic Therapies treat vaccination variant variants of concern virus weight loss [DOI] 10.1016/j.medj.2022.08.002 PMC 바로가기 [Article Type] Article
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19인터페론 경로 루푸스 위험 대립 유전자는 급성 COVID-19로 인한 사망 위험을 조절합니다Article Published on 2022-06-012022-09-11 Journal: Translational research : the journal of laboratory [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] Activation activator acute COVID-19 age allele alleles analyzed antiviral immunity Biomarker Blood BMI = body mass index body mass body mass index C-reactive protein cGMP contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 = coronavirus disease 2019 Critical CRP = C-reactive protein D-dimer death Defense disease domain Effect gain-of-function Genetic genetic information genetic risk factor Genotype groups Haplotype Helicase high risk idea IFIH1 IFIH1 = interferon-induced with helicase c domain 1 IFN IFN = interferon IFN pathway Increased interferon interferon regulatory factor IRF = interferon regulatory factor IRF5 IRF7 IRF8 lupus erythematosus modulate Mortality nucleotide NYU = New York University older subjects OR = odds ratio pathway Patient positive Predictive Primary outcome PRKG1 PRKG1 = protein kinase cGMP-dependent 1 protective effect Protective effects Protein protein kinase Regulatory risk risk allele risk factor risk of death significantly Single nucleotide polymorphism SLE SLE = systemic lupus erythematosus SNP = single nucleotide polymorphism STAT4 STAT4 = signal transducer and activator of transcription 4. subjects Support systemic lupus erythematosus Transcription troponin Type Type I IFN type I interferon variants viral infections York younger patient younger patients [DOI] 10.1016/j.trsl.2022.01.007 PMC 바로가기 [Article Type] Article
Divergent allostery reveals critical differences between structurally homologous regulatory domains of Plasmodium falciparum and human protein kinase Garticle Published on 2022-03-312024-09-01 Journal: Brain stimulation [Category] 말라리아, [키워드] Allostery cGMP chemical shift covariance analyses malaria NMR PKG Plasmodium falciparum [Article Type] article
Optimization, Production, Purification and Characterization of HIV-1 GAG-Based Virus-like Particles Functionalized with SARS-CoV-2Article Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome approach bioprocess cGMP Characteristics characterization co-expression coronavirus coronavirus spike protein COVID-19 design of experiments different disease DoE downstream Downstream process ENhance experiment expression Gag generate genetic material good manufacturing practice HEK293 HIV-1 immunogenic membrane protein methodology optimization Particle performed platform Production Protein purification robust Safe SARS-CoV-2 SARS-CoV-2 VLP Structure transient transfection vaccine candidate Vaccine development variants virus VLP VLP vaccines VLPs wild-type [DOI] 10.3390/vaccines10020250 PMC 바로가기 [Article Type] Article
Rapid cGMP manufacturing of COVID-19 monoclonal antibody using stable CHO cell pools안정적인 CHO 세포 풀을 사용하여 COVID-19 단일 클론 항체의 신속한 cGMP 제조Article Published on 2022-02-012022-09-11 Journal: Biotechnology and bioengineering [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] accelerated activities acute respiratory syndrome acute respiratory syndrome coronavirus approach Cell cell bank Cell culture cGMP cGMP manufacturing CHO cell CHO pools clinical trial clone comparability coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical demonstrated Final generate host cell material monoclonal antibodies monoclonal antibody pandemic performed Phase 1 Phase 1 clinical trial Proteins provided Rapid respiratory subsequent supply Testing timeline transposase [DOI] 10.1002/bit.27995 PMC 바로가기 [Article Type] Article
Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19치료 발전과 관련된 현재 지방 유래 줄기 세포(ADSC) 처리 개요: COVID-19 전후의 흐름도 및 규정 업데이트Review Published on 2021-01-042022-09-12 Journal: Stem Cell Research & Therapy [Category] MERS, 진단, [키워드] absence added ADSCs agency ATMPs autocrine benefit Blood Bone marrow Cell Cell therapy cellular cGMP comparison Comparisons complexity Cord blood COVID-19 criteria damaged dependent on discrepancies discrepancy Efficiency flow chart GMP good manufacturing practice HCT/P 351-361 highlight Infection initial involved Laboratory limitation main mechanism main mechanisms management manifestation Medical devices occur outcome overcome paracrine parameter pathway Patient patient safety protocol protocols raised regeneration regenerative regenerative medicine Regulation security setup Specific Standardization stem cell Stem cell therapy stem cells the patient therapeutic therapy Variability virus widespread [DOI] 10.1186/s13287-020-02006-w PMC 바로가기 [Article Type] Review
Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO projectCOVID-19 감염에서 NO-cGMP-PDE5 경로를 표적으로 합니다. 데달로 프로젝트Article Published on 2021-01-012022-09-11 Journal: Andrology [Category] SARS, 임상, 치료제, [키워드] acting activated T cells administration alveolar ANG-II anti-inflammatory response biological drug biological drugs cause Cell cGMP clinical trial clotting Complication complications of COVID-19 contraindication contraindications COVID-19 COVID-19 disease COVID-19 infection cyclic GMP cytokine cytokine release Cytokine storm Cytokines diabete diabetes Diabetes Mellitus Diabetic diffusion disease downregulation drug dysregulation endothelial Endothelial cell endothelial cell damage Evidence expressed favor fibrosis IL-6 immune system implication IMPROVE infiltration inhibiting interstitial interstitial pneumonia limit Liver function low-grade inflammation Lungs material men mesenchymal cells Metabolic diseases modulating monocyte Necrosis nitric oxide Numerous offer ongoing trial ongoing trials outbreak oxygen pandemic pathophysiology pathway Patient patients with COVID-19 PDE5 inhibitor PDE5 inhibitors performed positive presenting pro-inflammatory cytokines pulmonary artery pulmonary fibrosis raise reducing renal impairment resource respiratory respiratory infection responsible severe COVID-19 disease Sildenafil smooth muscle smooth muscle cell smooth muscle cells stability storm switching systematic review systemic disease T cells targeting temperature thrombotic Thrombotic complications transition type 2 diabete Type 2 diabetes mellitus Vascular vessel widespread [DOI] 10.1111/andr.12837 PMC 바로가기 [Article Type] Article
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2SARS-CoV-2에 대해 설계된 단백질 나노입자 백신에 의한 강력한 중화 항체 반응의 유도Article Published on 2020-11-252022-09-12 Journal: Cell [Category] Fulltext, SARS, 비임상, 진단, [키워드] antibody Antibody Response Antigen cGMP clinical trial computational protein design convalescent displaying domain ectodomain effective effort elicit elicited Epitopes highlight human sera immunogen immunogenic induce lower dose mice mutations nanoparticle Neutralizing antibody response Neutralizing antibody titer non-overlapping epitope platform potent Protective protective antibody response Protein RBD RBDs Receptor-binding domain Respiratory disease response risk robust Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2-RBD stability structure-based design susceptible the RBD the SARS-CoV-2 trimer utility Vaccine vaccine candidate vaccine for COVID-19 virus wall [DOI] 10.1016/j.cell.2020.10.043 PMC 바로가기 [Article Type] Article