Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 ExpressionImmunology Published on 2021-12-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation AEC airway angiotensin-converting enzyme 2 Calu-3 cell calu-3 cells CFTR chronic respiratory disease coronavirus disease Course COVID-19 COVID-19 severity COVID19 Critical Cystic cystic fibrosis deficiency develop epithelial cell Factor fibrosis flagella flagellin Health host protease identify immune response increase Increasing infect Infection Infectivity MAPK modulation P. aeruginosa Patient patients populations protease Protein Pseudomonas aeruginosa receptor recommendation reduce released risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection susceptibility TLR5 TMPRSS2 TMPRSS2 expression transmembrane transmembrane serine protease urgency virus particle [DOI] 10.3389/fimmu.2021.714027 PMC 바로가기 [Article Type] Immunology
Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19Review Published on 2021-11-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 Activation angiotensin-converting enzyme 2 angiotensin(1-7) Anti-inflammatory Cancer cardiopulmonary diseases cardiovascular conditions cascade cause changes in chronic respiratory disease classical cleavage clinical condition complex COVID-19 described diagnostic different diseases Effect Effects Factor form hypoxia hypoxic Lungs mechanism metabolite pharmacological target RAS receptor subsequent tissue vessel [DOI] 10.3390/ijms222312800 PMC 바로가기 [Article Type] Review
Do Old Age and Comorbidity via Non-Communicable Diseases Matter for COVID-19 Mortality? A Path AnalysisPublic Health Published on 2021-11-162022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] affected age Cancer chronic respiratory disease Comorbidity coronavirus country COVID-19 COVID-19 mortality death death rate deaths determinant determinants of COVID-19 mortality diabetes disease Europe Factors highest increase in intensity matter median age Mortality Non-communicable disease non-communicable diseases North America Oceania old age path path analysis proportion Quantitative raised Region regions South America statistically significant suggested Transmission vaccination variable Variation whole sample [DOI] 10.3389/fpubh.2021.736347 PMC 바로가기 [Article Type] Public Health
The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19Review Published on 2021-11-012022-11-01 Journal: Clinical and Molecular Allergy : CMA [Category] COVID-19, [키워드] ACE2 affected airway angiotensin-converting enzyme 2 Asthma Asthmatic patients cell line cells chronic lung diseases chronic obstructive chronic respiratory disease COPD coronavirus disease Coronavirus replication corticosteroid therapy Corticosteroids COVID-19 COVID-19 in patient Diseases evaluate Evidence General population high risk Hospitalization Hypothesis Lung disease modify observation outcome Patient patients patients hospitalized positive Predictive Prevalence Protective protective role pulmonary disease pulmonary diseases receptor reduced risk SARS-CoV-2 SARS-CoV-2 disease severe COVID-19 severity Steroids treated [DOI] 10.1186/s12948-021-00159-4 PMC 바로가기 [Article Type] Review
Immunity Profiling of COVID-19 Infection, Dynamic Variations of Lymphocyte Subsets, a Comparative Analysis on Four Different GroupsArticle Published on 2021-09-262022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ABG Admission affected analyzed assigned association B-lymphocyte blood gas analysis blood sample broncho-alveolar lavage fluid (BALF) CBC Cell cellular immunity China chronic respiratory disease Clinical characteristics collected Comparative conducted coronavirus COVID-19 COVID-19 infection COVID-19 patients COVID-19 severity criteria CT-scan dynamic Dyspnea Efficacy evaluate evaluated Fever Ground-glass opacities ground-glass opacity group healthy Humoral response Immunological response independent individual inflammatory status Lungs lymphocyte median age nasopharyngeal Neutrophils Novel coronavirus Patient peripheral peripheral lymphocyte Pneumonia positive Profiling progression RT-PCR SARS-CoV-2 subset T-lymphocyte tested Thoracic Treatment was performed [DOI] 10.3390/microorganisms9102036 PMC 바로가기 [Article Type] Article
A COVID-19-association-dependent categorization of death causes in 100 autopsy casesOriginal Article Published on 2021-09-112022-11-01 Journal: GeroScience [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age aggregate alteration alveolar fibrin analyzed association Autopsy Budapest cardiovascular disease categories category cause cause of death Central nervous system Cerebrovascular disease chronic respiratory disease Clinical management Clinical sign co-morbidity coronavirus correlation COVID-19 death defined demonstrated diabete Diffuse alveolar damage disease distribution females First wave histological abnormality Histopathology Hungary hypertension independent Infection kidney liver Liver disease lung Macrophage infiltration males malignant tumor Microscopy Mortality organ paraffin-embedded Patient performed polymerase chain reduced renal responsible SARS-CoV-2 scored second wave severity shift significantly supplementary material Symptoms tissue sample university Vascular ventilatory [DOI] 10.1007/s11357-021-00451-w PMC 바로가기 [Article Type] Original Article
Detection of spreader nodes in human-SARS-CoV protein-protein interaction networkBioinformatics Published on 2021-09-062022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] caused Characteristics chronic respiratory disease Committee Consensus coronavirus coronavirus 2 COVID-19 detection disease Edge ratio highlight Human-SARS-CoV protein–protein interaction network Hypothesis ICTV Lineage multiple organ failure Neighborhood density Node weight Novel coronavirus outbreak pandemic promote Protein protein-protein interaction Protein–protein interaction protein–protein interaction network reached respiratory SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spreadability index Spreader edges Spreader nodes Susceptible-infected-susceptible model taxonomy the disease [DOI] 10.7717/peerj.12117 PMC 바로가기 [Article Type] Bioinformatics
Physical and Mental Health Impacts of the COVID-19 Pandemic among US Adults with Chronic Respiratory ConditionsArticle Published on 2021-09-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval addition adjusted Anxiety association Asthma body ache Chest chill chills chronic chronic obstructive chronic respiratory condition chronic respiratory conditions chronic respiratory disease condition COPD COVID-19 COVID-19 pandemic death Depression evaluate Fever Health higher risk Impact mental health multinomial logistic regression multivariable Multivariable models pandemic physical Physical symptom Poisson regression Prevalence public health pulmonary disease respiratory Respiratory conditions SARS-CoV-2 survey Symptom Symptom management Symptoms used data [DOI] 10.3390/jcm10173981 PMC 바로가기 [Article Type] Article
Sars-Cov-2 Infection in Patients on Long-Term Treatment with Macrolides in Spain: A National Cross-Sectional StudyArticle Published on 2021-08-252022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] Ambulatory care Azithromycin characteristics of patients chronic respiratory disease Comorbidities Comorbidity concomitant treatments conducted Coronavirus disease-19 cough Course COVID-19 COVID-19 group cross-sectional death Diagnosis died Evidence Factor First wave Hospital admission inclusion criteria long-term treatment Macrolide macrolides median outcome outcomes outpatients pandemic Patient patients hospitalized patients treated Pneumonia Prevalence progression required SARS-CoV-2 SARS-COV-2 infection secondary severity severity of COVID-19 Shortness of breath Symptom Symptoms with COVID-19 [DOI] 10.3390/antibiotics10091039 PMC 바로가기 [Article Type] Article
Susceptibility of β-Thalassemia Heterozygotes to COVID-19Article Published on 2021-08-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] β-thalassemia Admission age Analysis association Atrial fibrillation Blood Characteristics chronic respiratory disease Clinical symptoms coronary disease coronavirus coronavirus disease COVID-19 COVID-19 severity diabetes disorder had no heterozygote Hospitalization hyperlipidemia hypertension ICU ICU admission ICU care intensive care Male sex Mortality observation participant Patient positive COVID-19 prevalent recruited reduced risk SARS-CoV-2 Sex single gene smoking status statistically significant susceptibility were assessed β-thalassemia [DOI] 10.3390/jcm10163645 PMC 바로가기 [Article Type] Article