Clathrin-mediated endocytosis
[대역어] None
[용어속성] Action
[용어속성] Action
The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?
Review article
[키워드] ACE2angiotensin-converting enzyme 2
acute respiratory distress syndrome
acute respiratory syndrome
angiotensin-converting enzyme 2
animal models
annexinA5
Anti-inflammatory
anti-malarial drug
Anti-phospholipid
anti-phospholipid syndrome
anti-thrombotic properties
Anti-viral
anti-viral effect
antigen-presenting cell
AnxA5annexinA5
APCantigen-presenting cell
aPLanti-phospholipid
APSanti-phospholipid syndrome
ARDSacute respiratory distress syndrome
Autoimmune disease
BMP/SMADbone morphogenetic/small mother against decapentaplegic
bone morphogenetic/small mother against decapentaplegic
caused
Cell culture
Chloroquine
chloroquine/hydroxychloroquine
chronic obstructive pulmonary disease
Clathrin-mediated endocytosis
Clinical course
Clinical efficacy
Clinical improvement
CMEclathrin-mediated endocytosis
COPDchronic obstructive pulmonary disease
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
COVID-19 patients
COVID-19Sars-Cov-2 infection
CQChloroquine
DCdendritic cell
dendritic cell
disease
divalent metal-ion transporter 1
DMT1divalent metal-ion transporter 1
drug
early endosome
EEearly endosome
Effects
Efficacy
Endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
endosomal NADPH oxidase
endothelial nitric oxide synthetase
eNOSendothelial nitric oxide synthetase
eNOXendosomal NADPH oxidase
EPOerythropoietin
ERendoplasmic reticulum
ERFEerythroferrone
ERGICendoplasmic reticulum-Golgi intermediate compartment
erythroferrone
erythropoietin
experimental evidence
ferritin
ferroportin 1
FPN1ferroportin 1
FTferritin
HAEChuman aortic endotelial cell
HAMPhepcidin
haptoglobin
HCMVHuman Cytomegalovirus
HCQ
HCQhydroxychloroquine
HCVHepatitis C virus
hemochromatosis
hemochromatosis gene
hemopexin
hepatitis C virus
hepcidin
HFEhemochromatosis gene
HHhemochromatosis
HIV-1Human Deficiency Virus 1
HPhaptoglobin
HPXhemopexin
human aortic endotelial cell
Human Cytomegalovirus
Human Deficiency Virus 1
human umbilical vein endothelial cell
HUVEChuman umbilical vein endothelial cell
Hydroxychloroquine
ICUIntensive Care Unit
IDAiron deficiency anemia
IDiron deficiency
IDUinfectious disease unit
IFN-γinterferon-γ
IFN1type interferon
IgGimmunoglobulin G
IL-12interleukin-12
IL-13interleukin-13
IL-17interleukin-17
IL-1βinterleukin-1β
IL-4interleukin-4
IL-6interleukin-6
Immunoglobulin G
immunomodulatory
Infection
infectious disease unit
intensive care unit
interferon-γ
interleukin-12
interleukin-13
interleukin-17
interleukin-1β
Interleukin-4
interleukin-6
iron deficiency
iron deficiency anemia
iron homeostasis
JAK/STAT3Janus kinase/signal transducers and activators of transcription 3
Janus kinase/signal transducers and activators of transcription 3
knowledge
lactoferrin
late endosome-lysosome
LELlate endosome-lysosome
less
LFlactoferrin
lipopolysaccharide
LPSlipopolysaccharide
mAbMonoclonal antibody
major histocompatibility complex
MAPKmitogen-activated protein kinase
matrix metalloproteinase
mechanism
metalloreductase six-transmembrane epithelial antigen of the prostate 3
MHCMajor Histocompatibility Complex
MHV-3mouse hepatitis virus type 3
mitogen-activated protein kinase
MMPmatrix metalloproteinase
MOImultiplicity of infection
monoclonal antibody
mouse hepatitis virus type 3
mucolipin 1
multiplicity of infection
Mviral envelope membrane protein
NADPH oxidase 2
natural killer
NETneutrophil extracellular trap
Neutrophil extracellular trap
NKnatural killer
NOX2NADPH oxidase 2
NPvirus nucleoprotein
pandemic
Patient
pharmacological
phosphatidylinositol binding clathrin assembly protein
PICALMphosphatidylinositol binding clathrin assembly protein
potential mechanism
Randomized controlled studies
RArheumatoid arthritis
RBCred blood cell
red blood cell
regimen
rheumatoid arthritis
SARS-COV-2 infection
severity
SLEsystemic lupus erythematosus (SLE)
STEAP3metalloreductase six-transmembrane epithelial antigen of the prostate 3
Sviral spike protein
systemic lupus erythematosus (SLE)
T helper
TFR1transferrin receptor 1
TFtissue factor
TGNtrans-Golgi network
TGTthrombin generating time
therapeutic
thrombin generating time
ThT helper
Tissue Factor
TLRToll-like receptor
TMPRSS2transmembrane serine protease 2
TNF-αtumor necrosis factor-α
Toll-like receptor
trans-Golgi network
transferrin receptor 1
transmembrane serine protease 2
treat
Treatment
TRPML1/MCOLN1mucolipin 1
tumor necrosis factor-α
type interferon
vascular cellular adhesion molecule 1
VCAM-1vascular cellular adhesion molecule 1
viral envelope membrane protein
viral infections
viral spike protein
virus nucleoprotein
β2-glicoprotein I
β2GPIβ2-glicoprotein I
[DOI] 10.1016/j.phrs.2020.104904 [Article Type] Review article
[DOI] 10.1016/j.phrs.2020.104904 [Article Type] Review article
Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials
Review
[키워드] ACE2
acute respiratory syndrome
block
caused
Clathrin-mediated endocytosis
clinical
clinical trial
clinical trials
combating
coronavirus
Coronavirus-2
COVID-19
described
disease
early stage
effective
endocytosis
ENhance
enzyme
facilitate
Health care system
Host
host protein
include
Infection
lack
life
macromolecule
mechanism
mechanisms
monoclonal antibodies
pandemic
polypeptides
Potential
presenting
Prevent
protease
PROTECT
reported
researcher
SARS-CoV-2
serine 2
small molecule
Spike protein
Stage
structures
sulfated polysaccharides
target
Therapeutics
TMPRSS2
transmembrane
treat
Vaccine
viral entry
viral fusion
viral infection
viral life cycle
viral spike protein
[DOI] 10.3390/ijms21155224 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms21155224 PMC 바로가기 [Article Type] Review
Repurposing chlorpromazine to treat COVID-19: The reCoVery study
Research article
[키워드] alleviate
Anti-SARS-CoV-2 Activity
antiviral activity
antiviral properties
biodistribution
blind
Brain
caused
chlorpromazine
Clathrin-mediated endocytosis
clinical trial
contagiousness
Course
COVID-19
COVID-19 infection
COVID-19 pandemic
CPZ
developmental
exhibit
form
France
ICU care
incidence
individuals
Infection
lung
multicenter
neuroscience
objective
observation
offer
Paris
Patient
Prophylactic
PROTECT
psychotropic drug
Randomized
Recentin
reduce
reported
repurposing
Repurposing of molecules
Respiratory Support
Saliva
SARS-CoV-2
severity
Side effects
standard treatment
symptomatic
therapeutic
therapy
Tolerance
treat
Trial
virulent
[DOI] 10.1016/j.encep.2020.05.006 [Article Type] Research article
[DOI] 10.1016/j.encep.2020.05.006 [Article Type] Research article
Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent Manner
Virus-Cell Interactions
[키워드] Actin
activated
Activation
Analysis
antiviral drug
approach
cause
Cell
cells
cellular entry
Central nervous system
China
cholesterol
clathrin
Clathrin-mediated endocytosis
CNS
confocal microscopy
contagious
coronavirus
death
disease
dissect
dominant negative
dysfunction
Encephalomyelitis
endocytic pathways
endocytosis
etiological agent
Exocytosis
GTPase
Guidance
Host
infected cell
Infection
Invasion
investigated
involved
knowledge
mechanism
molecular mechanism
mutant
nerve cell
Neural
neurological
neurovirulent
neurovirulent coronavirus
occur
overexpression
Pathogenesis
pathway
performed
pharmacological
porcine hemagglutinating encephalomyelitis virus
positive-sense
positively correlated
progression
Rab
required
RNA coronavirus
RNA interference
single-stranded
suggested
target
TEM
Therapeutic strategies
transfer
transmission electron microscopy
understanding
viral endocytosis
viral entry
viral entry pathway
virus
virus particles
were used
[DOI] 10.1128/JVI.01083-17 PMC 바로가기 [Article Type] Virus-Cell Interactions
[DOI] 10.1128/JVI.01083-17 PMC 바로가기 [Article Type] Virus-Cell Interactions
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
Research Article
[키워드] Cell
cell entry
Clathrin-mediated endocytosis
cleavage
conformational change
coronavirus
coronavirus
CoV
CoVs
demonstrated
endocytosed
endosomal maturation
endosomal pH
entry pathway
expressing
furin
furin cleavage site
fusion
fusion peptide
fusion protein
gene silencing
Genome
Host
host cell
host cell membrane
induce
Infection
influenza A virus
inhibited
introduced
investigated
late endosomes
less
lysosomal protease
lysosomal proteases
lysosome
membrane fusion
MERS
MERS-CoV
MHV
microenvironment
mouse hepatitis
murine hepatitis virus
negatively affected
occur
pathogen
plasma membrane
predicted
previous study
promote
protease
Protease inhibitor
Protein
proteolytic cleavage
Proteolytic processing
reporter
required
S protein
shown
siRNA
Specific
the S protein
upstream
vesicular stomatitis virus
virus
virus
while
zoonotic
[DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article