Complete blood cells count abnormalities in COVID-19 patients and their prognostic significance: Single center study in Makkah, Saudi Arabia전체 혈액 세포는 COVID-19 환자의 이상과 그 예후 중요성을 계산합니다: 사우디 아라비아 Makkah의 단일 센터 연구Article Published on 2022-06-012022-09-11 Journal: Saudi medical journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] abnormality Admission age Anemia Blood blood cell blood count C-reactive protein clinical disease clinically Complete complete blood count coronavirus disease COVID-19 COVID-19 patient COVID-19 severity CRP Decision making decrease detectable disease effective intervention elevated evaluate feature female ferritin force group Inclusion Inflammation Inflammatory marker inflammatory markers leucocyte leucocytosis lymphopenia male management moderate N/L N/L ratio neutrophil neutrophil count neutrophilia non-survivor Non-survivors occurred Older age Organ failure outcome parameter Patient patients Peripheral blood Platelets platelets count prognostic prognostic significance. Rapid test regimen regimens Respiratory disease respiratory diseases Saudi Arabia security Serum ferritin Serum level Severe case severe COVID-19 disease severity Significant significant decrease significantly viral infection were excluded [DOI] 10.15537/smj.2022.43.6.20210893 PMC 바로가기 [Article Type] Article
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-CSARS-CoV-2 오미크론 변이체에 대한 교차 반응성 면역은 이전에 COVID-19 또는 MIS-C가 있는 소아 환자에서 낮습니다.Article Published on 2022-05-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute COVID-19 age Alpha Analysis antibody Antibody titers Beta children clinical disease Cohort convalescent COVID-19 cross-neutralization Delta demonstrated evaluated expected Gamma Hospitalized Immunity less Mild MIS-C neutralization neutralization capacity neutralization titer Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers neutralizing capacity omicron Omicron variants outcome Outpatient outpatients Patient patients pediatric Pediatric patient Re-infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Support the SARS-CoV-2 Transmission vaccination variant variants virus-neutralizing [DOI] 10.1038/s41467-022-30649-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Seroconversion in an Adult Horse with Direct Contact to a COVID-19 IndividualCOVID-19 개인과 직접 접촉하는 성체 말의 SARS-CoV-2 혈청전환Case Reports Published on 2022-05-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] antibodies B.1.617.2 Blood clinical disease Clinical sign close contact Contact contact with COVID-19 Delta detectable diagnosed with COVID-19 direct contact ELISA exposure to feces horse Human individual infected with SARS-CoV-2 nasal neutralization test plaque reduction neutralization Plaque reduction neutralization test Prevent RT-qPCR SARS-CoV-2 secretion Seroconversion spillover Viral transmission [DOI] 10.3390/v14051047 PMC 바로가기 [Article Type] Case Reports
C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant InfectionC57BL/6J 마우스는 심각한 SARS-CoV-2 베타 및 감마 변종 감염을 모델링하는 데 적합하지 않습니다.Article Published on 2022-05-052022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Alpha angiotensin Angiotensin converting enzyme-2 ARDS B.1.1.7 B.1.351 B.1.617.2 Beta body weight Body Weight Changes C57BL/6 CCR2 change changes clinical disease deficiency Delta entry of SARS-CoV-2 eosin Evidence evidence of examined expression Gamma H&E H&E staining hACE2 hACE2 receptor hematoxylin histology IHC IHC staining immune immune deficiency Immunocompromised immunocompromised mice immunohistochemistry indicated infect Infection lung Lung pathology mice modeling Mutation P.1 pathologic pathological change pathological changes Probability qPCR RAG2 receptor replicate required SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 shown staining survival These data three group three groups transgenic mice Transmissibility variant variants variants of concern variants of SARS-CoV-2 Viral antigen Viral protein viral titer virulence VoC VOCs weight loss were used [DOI] 10.3390/v14050966 PMC 바로가기 [Article Type] Article
The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer전립선암이 있는 남성의 COVID-19 질병에 대한 안드로겐 결핍 요법의 영향Multicenter Study Published on 2022-05-022022-09-11 Journal: JNCI Cancer Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval addition adjusted Affect Analysis androgen Androgen receptor androgens body mass body mass index Cell clinical disease cohorts Comorbidity COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 illness death defined demonstrated Deprivation epithelial cells evaluated Follow-up hazard ratio higher risk Hospitalization illness Impact Logistic lower risk mechanical ventilation median median age multicenter multicenter study multivariable Not demonstrated Older outcomes overall survival oxygen Oxygenation Patient patients performed Prostate cancer protease Regression model regulated respiratory epithelial cells retrospective cohort SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 disease severe COVID-19 illness significantly statistical test statistically suggested supplemental oxygen survival therapy TMPRSS2 Treatment upregulated within 6 months [DOI] 10.1093/jncics/pkac035 PMC 바로가기 [Article Type] Multicenter Study
Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identifies Critical Biomarkers of COVID-19우한의 여러 단계에 있는 환자의 혈청 대사체학 특성 분석으로 COVID-19의 중요한 바이오마커 식별Article Published on 2022-05-022022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alpha-methylstyrene Biomarker Biomarkers caused characterization chavicol clinical disease clinical measurement clinical measurements comprehensive analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical death degranulation differentially expressed example feature identification immune responses information Intervention involved knowledge lead metabolism metabolite metabolites metabolomic metabolomic analysis metabolomics Pathogenesis pathway Patient patients performed phosphate physiological Platelet potential therapeutic agent potential therapeutic agents predicted propylparaben rehabilitation patient respiratory SARS-CoV-2 sera serum severe acute respiratory syndrome Coronavirus Spread Stage stages therapeutic agents therapeutic target therapeutic targets triethanolamine uninfected Wuhan [DOI] 10.3389/fcimb.2022.882661 PMC 바로가기 [Article Type] Article
Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal SocietyArticle Published on 2022-05-012022-10-05 Journal: European journal of pediatrics [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval Admission analyzed association C-reactive protein Chest Clinical characteristics clinical disease Clinical findings cough Course COVID-19 COVID-19 cases COVID-19 infection Fever Follow-up Hospitalization Hospitalized increased risk Infant intensive care unit International knowledge median Mild myocarditis Neonatal Neonate Neonates Newborn NICU normalized Odds ratio Patient positive RT-PCR Postnatal Prognosis prospective cohort study Prothrombin time receiving reported Respiratory Support SARS-CoV-2 sensitivity severe COVID-19 severe disease course significant difference Society specificity Symptom symptomatic tachypnea Transmission ventilatory support [DOI] 10.1007/s00431-021-04358-8 PMC 바로가기 [Article Type] Article
Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts서브게놈 및 게놈 SARS-CoV-2 전사체의 수준을 측정하기 위한 새로운 RT-ddPCR 분석Article Published on 2022-05-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] arising clinical disease Clinical significance contribute coronavirus COVID-19 Digital digital PCR discontinuous transcription droplet droplet digital PCR expression genomic genomic RNA gRNA locus novel other coronavirus other coronaviruses positive-sense Quantitative assays recent Regulation Replication replication of SARS-CoV-2 reverse transcription RNA SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity sgRNA sgRNAs subgenomic mRNA subgenomic mRNAs subgenomic RNA synthesis transcript Transcription transcripts viral pathogenesis viral transcription Viral transcription/replication. [DOI] 10.1016/j.ymeth.2021.04.011 PMC 바로가기 [Article Type] Article
COVID-19 and Light Chain Amyloidosis, Adding Insult to InjuryResearch article Published on 2022-04-012022-10-05 Journal: The American journal of medicine [Category] 임상, [키워드] acute respiratory syndrome Adding AL amyloidosis amyloidosis approach caused Cell chain clinical assessments clinical disease Comorbidity coronavirus coronavirus disease COVID vaccination COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine trials death demographics disease exclusion fatal disease Guidance highest highlight immunosuppressive Infection initial insult LIGHT light chain management manifestation monoclonal morbidity and mortality organ damage overlap Patient Plasma cell risk SARS-CoV-2 systemic illness Therapies Treatment unique virus [DOI] 10.1016/j.amjmed.2022.01.005 [Article Type] Research article
Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters햄스터에서 SARS-CoV-2 오미크론 변이체의 감소된 병원성Clinical and Translational Report Published on 2022-03-172022-09-14 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Abstract acute respiratory syndrome animal B.1.1.529 Beta clinical disease Context coronavirus COVID-19 Delta delta variant demonstrated detectable disease doses finding foundation funding hamster hamsters Histopathology humans Infection inoculated investigator less Lower respiratory tract lung lung parenchyma Lung pathology Massachusett NIH observation omicron Omicron variant pathogenic pathogenicity pathology provided Pulmonary pathology readiness reduced Region robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants strain suggested Syrian golden hamster Syrian Golden hamsters the SARS-CoV-2 tissue upper respiratory tract variant variants Viral load viral replication virus WA1/2020 weight loss were assessed [DOI] 10.1016/j.medj.2022.03.004 PMC 바로가기 [Article Type] Clinical and Translational Report