Streptococcus pneumoniae Strains Isolated From a Single Pediatric Patient Display Distinct Phenotypes단일 소아 환자에서 분리된 폐렴구균 균주들은 뚜렷한 표현형을 나타낸다.Original Research Published on 2022-03-312024-08-23 Journal: Frontiers in Cellular and Infection Microbiology [Category] 폐렴구균 감염증, [키워드] Bacteremia carbohydrate metabolism clinical isolates Meningitis raffinose Streptococcus pneumoniae virulence [DOI] 10.3389/fcimb.2022.866259 PMC 바로가기 [Article Type] Original Research
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응Article Published on 2022-03-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type [DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article
Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis짧은 사슬 지방산 아세테이트는 호흡기 세포융합 바이러스 세기관지염이 있는 유아의 세포에서 RIG-I에 의해 매개되는 항바이러스 반응을 유발합니다Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료제, [키워드] A549 A549 cell A549 cells Acetate Admission animal animals antiviral response Bronchiolitis Cell clinical clinical isolates code COVID-19 demonstrated disease severity duration of fever Effect epithelial cell epithelial cells examined expression faster fatty fecal gut microbiota Hospitalized IFNB1 Impact in vitro Increased increased expression Infant Infants Infection interferon interferon-stimulated gene interferon-stimulated genes intranasally ISG ISG15 ISGs isolate isolates lung MAVS mice microbial modulation mouse model OAS1 oxygen oxygen saturation Patient PROTECT receptor reduce reduced reduction in respiratory respiratory cell respiratory epithelial cell respiratory epithelial cells respiratory syncytial virus RIG-I RSV SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity significantly Stool strain Strains treated Treatment Trigger Viral load virus virus recognition [DOI] 10.1016/j.ebiom.2022.103891 PMC 바로가기 [Article Type] Article
Wastewater SARS-CoV-2 monitoring as a community-level COVID-19 trend tracker and variants in Ohio, United States미국 오하이오주의 커뮤니티 수준 COVID-19 추세 추적기 및 변종으로 폐수 SARS-CoV-2 모니터링Article Published on 2021-12-202022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 average B.1.427/429 can be used capital city caused Clinical data clinical isolates complementary Concentration confirmed cases confirmed COVID-19 case coronavirus correlated correlation COVID-19 COVID-19 case COVID-19 cases crAssphage. D614G determine E gene effective Effectiveness Epidemiology evaluated fecal gene regions global pandemic Health authority help isolate Longitudinal data N1 and N2 N501Y pandemic performed PMMoV Quadratic polynomial model quantified reduce SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus significantly Spearman statistical model Support Surveillance surveillance data target gene tested the SARS-CoV-2 Transmission United State vaccination variant variants variants of concern variants of SARS-CoV-2 Variation virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.149757 PMC 바로가기 [Article Type] Article
Development of a Multiplex Tandem PCR (MT-PCR) Assay for the Detection of Emerging SARS-CoV-2 Variants신흥 SARS-COV-2 변이체의 검출을위한 멀티 플렉스 탠덤 PCR (MT-PCR) 분석의 개발Communication Published on 2021-10-082022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] absence Alpha Applying approach B.1.1.7 B.1.1.7 lineage Chain Reaction clinical isolates clinical setting Concordance defined detection development evaluated example facilitated FIVE Genome sequencing genomic hospital identify in vitro diagnostic test information international public health isolate K417 Lineage Mutation National nucleic acid nucleotide P681 PCR polymerase chain polymerase chain reaction polymorphism Polymorphisms presence or absence Public health responses reference strain S gene SARS-CoV-2 SARS-CoV-2 lineage Sequence analysis Sequencing single nucleotide Single nucleotide polymorphism SNP tandem turnaround time UK hospital utilised variant variants variants of SARS-CoV-2 [DOI] 10.3390/v13102028 PMC 바로가기 [Article Type] Communication
Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis항진균제 감수성Online Only Articles Published on 2021-10-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] AIDS Amphotericin Antifungal Antifungal treatment clearance clinical isolates cryptococcal meningitis fluconazole flucytosine fungal HIV investigated isolate Meningitis monotherapy Mortality no correlation outcome Randomized controlled trial survival susceptibility susceptibility testing [DOI] 10.1093/cid/ciaa1544 PMC 바로가기 [Article Type] Online Only Articles
Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages야생에서 박테리아 진화를 정량화 : 캄 필로 박터 계통의 생일 문제Research Article Published on 2021-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy addition alteration Analysis approach approaches Bacteria Bacterial bacterium birthday problem Campylobacter Campylobacter jejuni clinical isolates CLOCK clock rate dataset DNA replication ecological effective estimates estimation event Evolution focus gastroenteritis gene transfer Genome genomic growth help horizontal gene Horizontal gene transfer Host humans identifying infect information introduced isolates lead Lineage lineages maintenance molecular molecular evolution Non-synonymous not applicable nucleotide nucleotide change nucleotide changes nucleotide sequence organism outbreak pathogen pathogenic bacteria pathogenic strains Pathogens Population Probability provide reducing reflect Region reproduction robust sampling selected Spread strain Strains synonymous toolkit transfer Transmission turnover Variation [DOI] 10.1371/journal.pgen.1009829 PMC 바로가기 [Article Type] Research Article
The CovR regulatory network drives the evolution of Group B Streptococcus virulenceCOVR 규제 네트워크는 그룹 B Streptococcus 독성의 진화를 주도합니다.Research Article Published on 2021-09-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation adhesin adhesins Adults Analysis architecture Bacterial binding characterized clinical isolates clone commensal bacterium Comparative Comparative analysis complex cross endothelial epithelial Evolution expression Factor functional Genes Genome group healthy heterogeneity Host impair infections Interaction intestinal invasive isolate Lineage loci majority master regulator Meningitis Mutation Neonatal neonatal meningitis occur opportunistic pathogen pan-genome pathogen Pathologies phenotypic Phosphorylation plasticity promoters Regulation Regulatory regulatory network responsible Signaling signaling pathway specific diseases Streptococcus Streptococcus agalactiae suggested surface protein surface proteins Transcriptome type strain Variability virulence virulence factors virulence gene virulence genes wild type wild type strain [DOI] 10.1371/journal.pgen.1009761 PMC 바로가기 [Article Type] Research Article
Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern우려되는 SARS-CoV-2 변이체를 탐지하기 위한 4가지 상용 자동화 항원 검사 비교Comparative Study Published on 2021-08-202022-09-10 Journal: Medical Microbiology and Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha Amino acid Analysis analytical sensitivity Antigen Asymptomatic automated Automated SARS-CoV-2 antigen test B.1.1.7 B.1.351 Beta biosafety level Biosafety Level 3 biosafety level 3 laboratory Characteristics clinical isolates clinical sensitivity comparable complement Containment coronavirus Cutoff detect Detection limit determine diagnostic test diagnostic tests DiaSorin Efficacy Elecsy Elecsys ELISA Euroimmun evaluated FIVE Fujirebio Germany hospitalized patients implementation independent isolate Laboratory level 3 LIAISON Mutation nucleic acid nucleocapsid nucleocapsid protein pandemic PCR-negative PCR-positive performed platform POCT point-of-care Quantitative ranged Rapid respiratory Respiratory samples Roche Roche Diagnostics SARS-CoV-2 SARS-CoV-2 variant sensitivity Sensitivity and specificity Specificities specificity study cohort Swab symptomatic patient Test variant VoC VOCs widespread [DOI] 10.1007/s00430-021-00719-0 PMC 바로가기 [Article Type] Comparative Study
Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples앰플리콘 기반 임상 샘플 시퀀싱을 사용한 SARS-CoV-2의 정확한 유전자형에 대한 권장 사항Article Published on 2021-07-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amplicon amplicon-based sequencing Analysis applicability approach artefact clinical isolates clinical sample clinical samples Cluster coronavirus detect dissemination effort Epidemiology error European evaluated facilitated Factors frequencies Frequency Genome genome sequence Genome sequences genomic Genotype genotypes genotyping guidelines identify implementation Inclusion independent isolate lack large cohort location Next-generation sequencing NGS pandemic recommendation recommendations reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences sequence sequencing data sequencing depth severe acute respiratory syndrome Coronavirus strain summer Support the SARS-CoV-2 genome Transmission Travel variant variants viral evolution viral genome viral genomes Viral load virus [DOI] 10.1016/j.cmi.2021.03.029 PMC 바로가기 [Article Type] Article