Pathogenicity is associated with population structure in a fungal pathogen of humansArticle Published on 2024-07-102024-09-05 Journal: bioRxiv [Category] update2024, [키워드] aspergillosis Aspergillus flavus clinical isolates keratitis pan-genome pathogenicity population genomics [DOI] 10.1101/2024.07.05.602241 PMC 바로가기 [Article Type] Article
Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolates and Diverse Laboratory-Adapted Lines말라리아 원충 플라스모디움 팔시파룸의 성적 헌신율 변동: 임상 분리주 및 다양한 실험실 적응주 간의 비교Article Published on 2022-11-212024-08-01 Journal: Microbiology Spectrum [Category] 말라리아, [키워드] clinical isolates differentiation gametocyte intraspecific variation sexual development [DOI] 10.1128/spectrum.02234-22 PMC 바로가기
Raman Spectroscopic Differentiation of Streptococcus pneumoniae From Other Streptococci Using Laboratory Strains and Clinical Isolatesarticle Published on 2022-07-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 폐렴구균 감염증, [키워드] Bacteria binary PLS-DA classification models chemometrics clinical isolates pneumococcus Raman spectroscopy Streptococcus [Article Type] article
Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO [DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2SARS-CoV-2에 대한 활성을 갖는 광범위한 1차 항바이러스제로서의 거대분자 바이러스 진입 억제제Article Published on 2022-07-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analyzed antiviral activity broad-spectrum antivirals Cell culture cell entry clinical isolates entry inhibitors gold Gold nanoparticle in vitro in vivo inhibitor inhibitors inhibitory activity investigated isolate macromolecular macromolecules mice pathogen Pathogens polyanions quantified respiratory syncytial virus respiratory syncytial virus (RSV). respiratory viral respiratory viruses Result RSV SARS-CoV-2 shown STYRENE sulfonate tested translational variants variants of concern viral cell virus viruses [DOI] 10.1002/advs.202201378 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other LineagesCOVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다Article Published on 2022-06-292022-09-11 Journal: mSphere [Category] COVID19(2023년), SARS, 변종, [키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19 [DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article
Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan우즈베키스탄의 임상 샘플에서 얻은 SARS-CoV-2의 게놈 서열 다양성Article Published on 2022-06-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha Amino acid amino acid substitution annotation association change clade clades clinical isolates clinical sample Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity D614G Deleterious Deletion Delta Denmark disease severity evidenced Evolution female followed by genetic diversity Genome Genomic analysis genomic change Genotype help Identified isolate isolates male Missense Missense mutation Missense mutations Mutation Nextstrain NSP Nsp12 nsp13 Nsp3 nsp4 NSP6 nucleotide Open reading frame ORF ORF7a Pathogenesis PCR-positive patient Protein reading regions Research Russia SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severity significantly SNP SNPs subclade Substitution synonymous Tashkent the Spike two group two groups USA variant variants Variation WGS whole genome sequence with COVID-19 [DOI] 10.1371/journal.pone.0270314 PMC 바로가기 [Article Type] Article
Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, Beta, Delta, and Omicron variants조상 SARS-CoV-2, 베타, 델타 및 오미크론 변이체의 임상 분리주에 대한 회복기 및 백신 접종 혈청의 면역원성Article Published on 2022-06-102022-09-11 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] antibody Antibody titers Beta booster vaccination Canada CL3 clinical isolates convalescent convalescent individual convalescent individuals convalescent sera coronavirus coronavirus disease COVID-19 Delta delta variant demonstrated dose foundation Government immunogenicity individual induce initiative Innovation isolate long-term Major microneutralization Ministry of Agriculture Moderna multiple mutation multiple mutations neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer omicron Omicron variant Pfizer raising receive recipient reduced Research SARS-CoV-2 Science sera significantly higher Spike protein the spike protein vaccinated individual vaccinated individuals Vaccine variant variants variants of concern VIDO virus VoC VOCs [DOI] 10.1016/j.medj.2022.04.002 PMC 바로가기 [Article Type] Article
In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolatesArticle Published on 2022-06-012023-06-13 Journal: Virologica Sinica [Category] B형 간염, Fulltext, [키워드] clinical isolates genotype B genotype C Hepatitis B virus (HBV) Infectivity sL21S. [DOI] 10.1016/j.virs.2022.03.008 PMC 바로가기
Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article