Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings다양한 임상 환경에서 면역 저하 환자의 오미크론 변이체에 대한 동형 및 이형 면역 반응Article Published on 2022-08-042022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] CD4 CD8 Cellular immune response clinical setting comparable controls cross-neutralization D614G Delta Delta variants disease severity dose Host humoral identify immune immune response immune responses Immunocompromised Immunocompromised patient Immunocompromised patients implication Infection magnitude neutralization neutralizing antibody omicron Organ transplant Patient patients peptide peptide pools Pseudovirus neutralization assay Re-infection recipient response responses risk of infection SARS-CoV-2 severe COVID-19 subset T-cell Response T-cell responses uninfected Vaccine variant variants [DOI] 10.1038/s41467-022-32235-x PMC 바로가기 [Article Type] Article
The Clinical Efficacy and Safety of Anti-Viral Agents for Non-Hospitalized Patients with COVID-19: A Systematic Review and Network Meta-Analysis of Randomized Controlled TrialsCOVID-19를 가진 비 병원 환자에 대한 항 바이러스 제제의 임상 효능 및 안전성 : 무작위 대조 시험의 체계적인 검토 및 네트워크 메타 분석Review Published on 2022-08-022022-08-31 Journal: Viruses [Category] meta-analysis, 임상, 치료제, [키워드] adverse event adverse events agent anti-viral agent anti-viral agents Anti-viral treatment best calculated clinical Clinical efficacy clinical setting Cochrane Library Controlled controlled trials COVID-19 death determined by Disease progression followed by Hospitalization increased risk Intravenous remdesivir investigated lowest molnupiravir network Network meta-analysis Nirmatrelvir nirmatrelvir plus ritonavir Patient patients with COVID-19 Placebo Probability Randomized controlled trial RCT RCTs receiving registry Remdesivir review risk risk of COVID-19 Ritonavir Safety searched shown significantly lower the WHO tolerable Treatment Web of Science WHO International Clinical Trials Registry Platform [DOI] 10.3390/v14081706 PMC 바로가기 [Article Type] Review
Early diagnosis by antigen test kit and early treatment by antiviral therapy: An ambulatory management strategy during COVID-19 crisis in Thailand항원검사키트를 통한 조기진단과 항바이러스제 조기치료: 태국 코로나19 위기 상황에서의 보행관리 전략Article Published on 2022-07-292022-09-11 Journal: Medicine [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antigen Antiviral Antiviral treatment baseline Care Chain Reaction clinic Clinical characteristics clinical setting collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis COVID-19 outbreak COVID-19 severity criteria demographic demographic data Diagnosis diagnostic diagnostic test disease disease detection Disease progression early diagnosis early treatment Favipiravir female indicated Infection influence management medication mortality rate mortality rates Most patient Most patients outcome Patient polymerase chain reaction positive proportion real-time reverse transcription-polymerase chain reaction receiving Registered Retrospective study risk factor Risk factors severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease significantly significantly more Symptom symptom onset Treatment treatment regimen unique vaccination Vaccination Status [DOI] 10.1097/MD.0000000000029888 PMC 바로가기 [Article Type] Article
Prognostic Role of sST2 in Acute Heart Failure and COVID-19 Infection-A Narrative Review on Pathophysiology and Clinical Prospective급성 심부전 및 COVID-19 감염에서 sST2의 예후 역할 - 병태생리학 및 임상 전망에 대한 내러티브 검토Review Published on 2022-07-262022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Acute heart failure acute infection adverse outcome adverse outcomes Biomarker Biomarkers cardiovascular diseases clinical Clinical practice clinical setting COVID-19 COVID-19 infection Diagnosis early diagnosis failure heart heart disease heart failure IL33 interleukin involved ischemic heart disease mechanism molecular mechanisms narrative prognostic Prospective receptor review risk risk stratification role SARS-CoV-2 Signaling signaling pathway specific treatment sST2. ST2 therapy [DOI] 10.3390/ijms23158230 PMC 바로가기 [Article Type] Review
The importance of effect sizes when comparing cycle threshold values of SARS-CoV-2 variantsSARS-CoV-2 변이체의 주기 임계값을 비교할 때 효과 크기의 중요성Article Published on 2022-07-212022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] age Alpha variant Alpha VOC Analysis ANOVA Beta calculation carried clinical setting Combination Ct values cycle threshold Cycle threshold value effect size effect sizes estimate Gender group investigated magnitude marker mechanism mutations Occurrence onset of symptoms outpatients P-value p-values Patient positive sample post-hoc Retrospective study SARS-CoV-2 SARS-CoV-2 variant significant effect significantly statistical analysis study period Transmission variants of SARS-CoV-2 Viral load viral variant VoC were recorded wild type [DOI] 10.1371/journal.pone.0271808 PMC 바로가기 [Article Type] Article
Self-evolving vision transformer for chest X-ray diagnosis through knowledge distillation Research Published on 2022-07-042022-10-05 Journal: Nature Communications [Category] 치료기술, [키워드] absence annotation applicability Chest chest X-ray clinical setting COVID-19 Diagnosis external validation hospital IMPROVE knowledge offer Radiologists robust transformer Tuberculosis [DOI] 10.1038/s41467-022-31514-x [Article Type] Research
T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cellsSARS-CoV-2-특이적 T-세포 검출을 위한 T-세포 증식 분석Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] an area Analysis antibody approved AUC B-cell B-cell response blood sample Blood samples carried cellular cellular immune responses clinical setting clinical settings complex Control control group controls ELISA assay False positive False positives Health care Health care worker health care workers humoral Humoral and cellular immune responses IgG immune immune responses Immunoglobulin Immunoglobulin G Infection less lymphocyte lymphocyte transformation Lymphocyte transformation test majority membrane N and M non-infected nucleocapsid peptide peptide pool peptide pools proliferation Protein representing resulting ROC analysis S protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Stimulation T-cell T-cell Response T-cell responses the S protein the S1 subunit the SARS-CoV-2 thymidine Trigger vaccinated individual vaccination Vaccines were recorded [DOI] 10.1016/j.cca.2022.05.025 PMC 바로가기 [Article Type] Article
Mobile app and digital system for patients after myocardial infarction (afterAMI): study protocol for a randomized controlled trial심근경색 후 환자를 위한 모바일 앱 및 디지털 시스템(afterAMI): 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-06-212022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] Acute myocardial infarction Admission analyzed cardiac Cardiac rehabilitation Cardiology cardiovascular risk factor cardiovascular risk factors Care chair clinical setting comprehensive evaluation Contact Department described discharge effective endpoints Evidence example Healthcare professional hospital IMPROVE Inclusion initial International knowledge life medical history medication Mobile Mobile App Mobile application Myocardial Myocardial infarction offer Open-label Participants Patient patients Perspective Previous studies previous study Prognosis protocol Quality of life Randomized Randomized controlled trial randomized trials recruited rehabilitation required single-center study Study protocol subject telehealth Telemedicine the patient undergo university vital sign Warsaw [DOI] 10.1186/s13063-022-06463-x PMC 바로가기 [Article Type] Article
Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): A point-of-care PCR test for rapid detection of SARS-CoV-2 infectionDASH(Diagnostic Analyzer for Selective Hybridization) 임상 평가: SARS-CoV-2 감염의 신속한 검출을 위한 현장 진료 PCR 검사Article Published on 2022-06-162022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed Analyzer Antigen calculated Cepheid clinical clinical setting collected Concordance conducted correlated COVID-19 COVID-19 symptoms COVID-19 vaccine cross-sectional cross-sectional study DASH dose doses enrolled evaluated female gold gold standard hybridization information Laboratory median age mRNA nasal swab negative and positive Negative predictive value participant PCR PCR test performed POC point-of-care positive Positive predictive value Predictive Predictive value provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR sensitivity specificity speed Swab symptomatic symptoms of COVID-19 vaccination was tested without symptom [DOI] 10.1371/journal.pone.0270060 PMC 바로가기 [Article Type] Article
Impact of COVID-19 lockdown on diabetes management and follow-up in a broad population in Spain스페인의 광범위한 인구에서 COVID-19 잠금이 당뇨병 관리 및 후속 조치에 미치는 영향Article Published on 2022-06-012022-09-12 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affected age all age groups analysed analysis of variance ANOVA change clinical setting Complete COVID-19 Deleterious diabete diabetes control evaluate evaluated Follow-up Gender General population glycaemic control greater groups HbA1c Impact individual individuals investigated lockdown Logistic regression analysis management measure not significantly different Older partial lockdown repeated measure retrospective Spain Spanish study period tested [DOI] 10.1111/eci.13771 PMC 바로가기 [Article Type] Article