clones – Page 2 – Communicable Diseases Research

Signature of long-lived memory CD8 + T cells in acute SARS-CoV-2 infection

급성 SARS-COV-2 감염에서 장기 기억 CD8 + T 세포의 시그니처

Article

Published on 2021-12-072022-08-31
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘,

A common methodological phylogenomics framework for intra-patient heteroplasmies to infer SARS-CoV-2 sublineages and tumor clones

SARS-COV-2 Sublineages 및 종양 클론을 추론하는 환자 내 이종성을위한 일반적인 방법 론적 계통 발생 유전학 프레임 워크

Research

Published on 2021-11-162022-09-10
Journal: BMC Genomics [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] Accuracy acquisition assumption Birth Cancer cancer patient capture clinically Clonal evolution clone clones co-infecting COVID-19 COVID-19 patient disease Evolution Frequency Genetic genetic material genomic genomic data genomic read genomic variant handle heterogeneity highlighting identify illness implication in viral Infection information methodological Mutation offer Phylogenetic Phylogenetic tree phylogenies Phylogenomics Phylogeny provide resistance mechanism resistance mechanisms Result SARS-CoV-2 SARS-CoV-2 virus supplementary material targets the mean the SARS-CoV-2 virus therapeutic therapy Treatment Tumor Tumor evolution undergo variant frequency Viral
[DOI] 10.1186/s12864-021-07660-9 PMC 바로가기 [Article Type] Research

Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies

회복기 환자 유래 항체에 의한 SARS-CoV-2의 RBD 돌연변이 균주의 교차 중화

Article

Published on 2021-11-012022-09-11
Journal: Biotechnology Journal [Category] MERS, SARS, 변종, 진단,

[키워드] 293T cells ACE2 angiotensin angiotensin converting enzyme antibody Bin2 binding binding affinity Cell clone clones convalescent patient COVID-19 pandemic COVID-19 recovered patient enzyme epitope global pandemic group hACE2 high affinity IgG inhibitory Interaction live SARS-CoV-2 MOST mutant mutant strain mutants mutations N501Y neutralized Neutralizing Neutralizing antibodies neutralizing antibody overexpressed patient-derived antibody libraries. positive preventing infection pseudovirus entry RBD RBDs receptor Receptor binding domain SARS-CoV-2 SARS-CoV-2 strain screened spike Spike protein the antibody therapeutic interventions V367F Vero-E6 cells Viral viral infection wildtype
[DOI] 10.1002/biot.202100207 PMC 바로가기 [Article Type] Article

Impact of Host Immune Status on Discordant Anti-SARS-CoV-2 Circulating B Cell Frequencies and Antibody Levels

불일치 항 SARS-CoV-2 순환 B 세포 주파수 및 항체 수준에 대한 숙주 면역 상태의 영향

Article

Published on 2021-10-142022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

[키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody synthesis Antiviral antiviral antibodies B cell B cell repertoire caution circulating clone clones Comorbidities convalescent COVID-19 determined by develop failure frequencies Frequency functional healthcare personnel hospitalized patient hospitalized patients Human monoclonal antibody immortalized immunofluorescence Impact indirect immunofluorescence individual infected cells Level low-grade inflammation Neutralizing protective immunity reflect regulate responses reveal SARS-CoV-2 SARS-CoV-2 infected cells severe COVID-19 Severe patient severe patients statistically status two group two groups
[DOI] 10.3390/ijms222011095 PMC 바로가기 [Article Type] Article

Human CD4 + T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential

치료 가능성이 있는 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질의 우세한 에피토프에 특이적인 인간 CD4 + T 세포

Article

Published on 2021-09-012022-09-11
Journal: Clinical and experimental immunology [Category] SARS, 치료법,

[키워드] adverse effects Antigen cancer patient Cancer patients CD4 Cell therapy cellular clone clones coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine response develop dominant epitope Efficacy effort epitope epitope. Epitopes examined focus haematopoietic stem cell transplantation Human identify immune response immune responses immunocompromised individuals immunodominant epitope immunodominant epitopes immunological protection long-lasting Neutralizing antibodies neutralizing antibody nine nucleocapsid protein Protective Protein SARS-CoV-2 SARS-CoV-2 virus sensitivity sequence sequencing approach short-lived spike Spread stem cell Stem cell transplantation T cell T cell receptor T cell response T cell responses T cells TCR the SARS-CoV-2 virus therapeutic potential therapy These data Treatment Vaccine while
[DOI] 10.1111/cei.13627 PMC 바로가기 [Article Type] Article

Massive surge of mRNA expression of clonal B-cell receptor in patients with COVID-19

Research Article

Published on 2021-08-102022-10-31
Journal: Heliyon [Category] COVID-19,

[키워드] accounted acquisition acute respiratory syndrome adaptive Analysis B cell B cells B-cell B-cell receptor BCR CDR3 clinical symptom clinically clones Cluster complementarity-determining region composed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease dominant evaluate expected fluctuation Frequency Immunity Immunotherapy massive mRNA expression network analysis Neutralizing antibodies neutralizing antibody occur Patient patients with COVID-19 primary mechanism raise reached receptor repertoire Repertoire assay Result sequence severe acute respiratory syndrome coronavirus 2 symptom onset the timing unique
[DOI] 10.1016/j.heliyon.2021.e07748 PMC 바로가기 [Article Type] Research Article

Identification of Human SARS-CoV-2 Monoclonal Antibodies from Convalescent Patients Using EBV Immortalization

Article

Published on 2021-07-052022-10-27
Journal: Antibodies [Category] COVID-19,

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

SARS-CoV-2에 대한 CD4 T 세포 반응의 면역우세 및 교차 반응성의 클론 분석

Report

Published on 2021-05-182022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 치료법,

Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

Report

Published on 2021-05-142022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS,

[키워드] acute respiratory syndrome Adults age analyzed antigen-specific antibody B cell B cell memory B cells BCR Blood blood sample cell population childhood children clone clones contribute coronavirus Coronaviruses COVID-19 COVID-19 pandemic cross-reactive cross-reactivity Deceased determine distribution Donor donors Ebola virus evaluated Evolution Frequency greater group heavy chain highlight humoral immune memory individuals Infection Lymphoid tissue memory B memory B cell organ other coronaviruses pathogen Pathogens pediatric promote receptor reported response SARS-CoV-2 Science sequence serology spleen susceptibilities switching tissue virus
[DOI] 10.1126/science.abf6648 PMC 바로가기 [Article Type] Report

Enhanced SARS-CoV-2 neutralization by dimeric IgA

이량체 IgA에 의한 향상된 SARS-CoV-2 중화

Comparative Study

Published on 2021-01-202022-09-10
Journal: Science Translational Medicine [Category] MERS, SARS, 바이오마커, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect antibody antibody isotype antibody isotypes average B cell B cells candidate cause Cell clone clones Cohort convalescent individual coronavirus coronavirus disease Coronavirus disease 2019 correlated covalent linkage COVID-19 demonstrated Diagnosis dimeric Efficacy enhanced form forms Human IgA IgA antibodies IgA antibody IgA response IgA responses IgG IgG responses Immunoglobulin Immunoglobulin G individual induce infect infected with SARS-CoV-2 initial investigated less Mild monomer monomeric MOST mucosa mucosal surface mucosal surfaces mucosal tissues nasopharynx neutralize neutralized Neutralizing antibodies neutralizing antibody Neutralizing antibody response plasma progenitor cells respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2–specific antibodies SARS-CoV-2–specific antibody secretory antibodies severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmissibility upper respiratory tract Vaccine vaccine efficacy Viral viral spread virus with COVID-19
[DOI] 10.1126/scitranslmed.abf1555 PMC 바로가기 [Article Type] Comparative Study