Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concernArticle Published on 2022-10-152022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Anti-spike antibody antibody cross-reactivity antigens approach Beta clone clones cross-reactivity discriminatory power Diseases Donor exhibit Gamma IgG1 IgG1 antibodies IgG1 response individual donor Infection lack MONITOR observation plasma plasma IgG1 polyclonal profile Protein recognize response responses SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant Spike protein Support the SARS-CoV-2 trimer variant virus Virus neutralization VoC VOCs wild type Wuhan [DOI] 10.1038/s41467-022-33899-1 PMC 바로가기
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotypeArticle Published on 2022-10-072022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] animal model bronchial epithelial cell cell culture system clone clones cultures Delta epithelial ferret hamsters immune evasion immunized in vitro in vivo Infection K18-hACE2 mice less mice mutant naïve nasal observé pathogenicity phenotype reduced replication Replication spike gene Surveillance the SARS-CoV-2 VoC [DOI] 10.1038/s41467-022-33632-y PMC 바로가기
Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein Research Published on 2022-08-042022-10-05 Journal: Scientific Reports [Category] 진단, [키워드] antibodies antibody Central nervous system clone clones comparison conformational conserved diagnostic disease dominant E. coli ELISA enzyme-linked immunosorbent epitope flanking region GenBank generate Human IFA immunofluorescence microscopy Infection infections isolate isolates Isolation Mild peptide positive Protein purified representing respiratory symptom scFv sequence tested unique variety virus virus sample was used [DOI] 10.1038/s41598-022-17678-y [Article Type] Research
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boostSARS-CoV-2 mRNA 부스트 후 증가된 기억 B 세포 효능 및 폭Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] accompanied analysed antibody breadth Cell clone clones Cohort consequence conserved conserved regions convalescent individual disease domain dose effective Evolution expansion explain help increase in Increased individual Infection memory memory B memory B cell memory B cells Memory cells mRNA boost mRNA vaccine neutralized Neutralizing antibodies neutralizing antibody omicron Omicron variant potency PROTECT receiving Receptor-binding domain reduced Region respond SARS-CoV-2 second dose significantly increased the RBD these cell These cells These data Vaccine variant variant of SARS-CoV-2 variants [DOI] 10.1038/s41586-022-04778-y PMC 바로가기 [Article Type] Article
Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection푸린 및 TMPRSS2 내성 스파이크는 SARS-CoV-2 치명적인 감염에 대한 강력한 체액 및 세포 면역을 유도합니다Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice Against Amino acid antibody response against blocked C-terminal CD8 cleavage site clone clones COVID-19 vaccine effective Express furin furin cleavage furin cleavage site hamsters identify in some induce intranasal lethal Mutation mutations produced protective immunity Protein pseudotype Replication replication-competent. Resistant robust S antigen S protein S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant single dose spike Spike protein T cell T cell response the SARS-CoV-2 TMPRSS2 transgenic unmet need vaccination Vaccine Vaccine design variant vesicular stomatitis vesicular stomatitis virus virus VSV was used [DOI] 10.3389/fimmu.2022.872047 PMC 바로가기 [Article Type] Article
Differences in SARS-CoV-2 Vaccine Response Dynamics Between Class-I- and Class-II-Specific T-Cell Receptors in Inflammatory Bowel Disease염증성 장 질환에서 클래스 I 및 클래스 II 특정 T 세포 수용체 간의 SARS-CoV-2 백신 반응 역학의 차이Article Published on 2022-04-082022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Adaptive immune response adaptive immune responses age analyzed antibody antibody levels Antigen antigens BNT162b2 booster bowel characterized clone clones Cohort conditions Critical deficiencies deficiency difference Dynamics expansion Factor HCWs Health care Health care worker health care workers IBD immune factors immune response immune responses Immune-mediated immunodeficiency immunomodulatory induce Infection Inflammatory Inflammatory bowel disease inflammatory disease Inflammatory diseases intestinal mechanism molecular mRNA mRNA vaccine mRNA-1273 vaccine Patient patients protocols response responses robust SARS-CoV-2 SARS-CoV-2 (COVID-19) SARS-CoV-2 vaccination sequenced Sequencing significant difference significant differences Spectrum stratified subset T-cell T-cell receptor T-cell repertoire T-cell Response T-cell responses T-cells TCR the patient Treatment understanding vaccination vaccination response vaccination schedule Vaccine [DOI] 10.3389/fimmu.2022.880190 PMC 바로가기 [Article Type] Article
The Relationship Between Convergent IGH Signatures and Severity of COVID-19 Patients by Next-Generation Sequencing of B-Cell RepertoireMicrobiology Published on 2022-02-092022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome analyzed association B cell B-cell B-cell repertoire BCR clones coronavirus coronavirus disease COVID-19 Critical Deterioration FIVE Frequency groups healthy donor IGH Inpatient Mild motif next generation sequencing no significant difference object outcome Patient patients receptor recognize relationship repertoire Result SARS-CoV-2 severity signature significantly higher significantly lower three groups Treatment Vaccine development [DOI] 10.3389/fmicb.2021.833054 PMC 바로가기 [Article Type] Microbiology
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19단일 세포 다중 오믹스는 진행성 COVID-19에서 선천 면역 체계와 적응 면역 체계의 불일치를 나타냅니다.Article Published on 2022-01-212022-09-12 Journal: Nature Communications [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] activated adaptive adaptive immune system Analysis approach B cell CD8 Cell cellular cellular immunity classical monocyte classical monocytes clone clones Course COVID-19 Disease progression dysregulated immune response dysregulated immune responses Effect Frequency Gene Expression hallmark hallmarks highlight hospitalized patient hospitalized patients immune immune profiling immune response immune responses immune signature Immunity immunopathology information innate and adaptive immunity Interaction LAG-3 Lineage marker Monocytes mutated pathology patients patients with COVID-19 probe progressive COVID-19 progressive disease Protein reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 single-cell skewed Systems analysis T cell T cell receptor T cells the SARS-CoV-2 virus Tocilizumab viral infection [DOI] 10.1038/s41467-021-27716-4 PMC 바로가기 [Article Type] Article
Development of a RT-LAMP assay for detection of SARS-CoV-2Article Published on 2022-01-012022-11-15 Journal: The Indian journal of medical research [Category] SARS, 치료기술, [키워드] amplification assays carried caused clones country COVID-19 detect development diagnostic equipment evaluate evaluated in vitro transcription incubated isothermal isothermal amplification less N gene nucleocapsid pandemic platform polymerase chain primer reaction reduce Result RNA rRT-PCR RT-LAMP SARS-CoV-2 SARS-CoV-2 RNA Sensitivity and specificity tested throat swab Visual detection were recorded Wuhan, China [DOI] 10.4103/ijmr.IJMR_713_21 PMC 바로가기
Serotypes and Clonal Composition of Streptococcus pneumoniae Isolates Causing IPD in Children and Adults in Catalonia before 2013 to 2015 and after 2017 to 2019 Systematic Introduction of PCV132013년부터 2015년까지와 2017년부터 2019년까지 PCV13의 체계적인 도입 이전에 카탈로니아에서 어린이와 성인에게 IPD를 유발하는 폐렴구균 분리주의 혈청형 및 클론 구성Research Article Published on 2021-12-082024-07-30 Journal: Microbiology Spectrum [Category] 폐렴구균 감염증, [키워드] clones invasive pneumococcal disease pneumococcal conjugate vaccines serotypes Streptococcus pneumoniae [DOI] 10.1128/Spectrum.01150-21 PMC 바로가기 [Article Type] Research Article