The Dysregulation of the Renin-Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity혈청 단백질체학으로 연구한 COVID-19에서 레닌-안지오텐신 시스템의 조절장애: 질병의 중증도에 따라 안지오텐시노겐 증가Article Published on 2022-04-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] ACE Activation AGT analyses Analysis angiotensin angiotensinogen bradykinin Cohort complement Complement activation Concentration convalescent coronavirus correlated COVID-19 COVID-19 infection CPN Critically ill critically ill patients disease severity expression expression analysis followed by group healthy probands hospitalized COVID-19 patients hospitalized patient hospitalized patients increase indicated Infection investigated Kallikrein Kallikrein-kinin system KLKB1 KNG1 mass spectrometry pathophysiological pathway patients plasminogen profile Protein protein expression proteomics RAS Renin renin-angiotensin system separated serum Serum protein significantly statistical System was performed [DOI] 10.3390/molecules27082495 PMC 바로가기 [Article Type] Article
Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀Article Published on 2022-04-012022-09-11 Journal: Journal of Proteome Research [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics. [DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionCOVID-19 폐 부검 표본의 다중 디자인 차등 발현 프로파일링은 상당히 규제 완화된 염증 경로 및 SFTPC 손상된 전사를 나타냅니다Article Published on 2022-03-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] Activation Autopsy carried cathepsin Cathepsin C CD163 CFB Clinical diagnosis complement Complement activation controls COVID-19 COVID-19 patient COVID-19-related death CTSC deaths deregulation develop differential expression effective effective therapy FFPE formalin formalin-fixed paraffin-embedded Gene expression profiling had no high viral load IFIT1 immune signature immunohistochemistry Impaired Inflammation ISG15 lung lung damage Macrophage macrophage polarization mechanism MS4A4A Nasopharyngeal swab OAS1 overexpression paraffin pathway pharmacological strategies PKM positive potential therapeutic targets Prevent probe Profiling Protein protein C pulmonary viral quantified required Respiratory disease RNA RNA-Seq RSAD2 SARS-CoV-2 SARS-COV-2 infection selected Seven SFTPC Siglec-1 SIGLEC1 signaling pathway specimen tissue sample tissue samples transcriptomic Transcriptomic profiling type I interferon Viral load were used [DOI] 10.3390/cells11061011 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
Activation of Complement Components on Circulating Blood Monocytes From COVID-19 PatientsCOVID-19 환자의 순환 혈액 단핵구에 대한 보체 성분 활성화Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation acute infection amyloid A Asymptomatic Biomarker blood monocyte C1q caused CD55 Cell cell surface cells cellular characterized circulating classical Coagulopathy complement Complement activation Complement inhibitor component coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient COVID-19 patients CRP death downstream elevated HCs healthy control healthy controls highlight hyperinflammation implicated IMPROVE increase Increased Increases Inflammation Inflammatory marker inhibitor Interaction membrane membrane-bound monocyte Monocytes multi-organ failure myeloid cell myeloid cells plasma remained SARS-CoV-2 virus serum amyloid Severe infection surface expression the cell the SARS-CoV-2 virus upregulated upregulation with COVID-19 [DOI] 10.3389/fimmu.2022.815833 PMC 바로가기 [Article Type] Immunology
Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults입원하지 않은 청소년 및 젊은 성인의 급성 COVID-19의 염증 표지자, 폐 기능 및 임상 증상Immunology Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] Activation Adolescent adolescents age alteration association baseline baseline data clinical clinical symptom Clinical symptoms cohort study complement Complement activation Complement activation products Control controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 group Cytokines detect disease Effect ELISA Eotaxin female function globe GM-CSF groups IL-12 IL-13 IL-1β IL-4 IL-7 IL-8 independent independent of Infection Inflammatory Inflammatory marker inflammatory markers investigated IP-10 Male sex marker MIP-1α multiplex Non-COVID-19 non-hospitalized Observational cohort study plasma Plasma cytokine Plasma levels pulmonary Pulmonary function Questionnaires Result SARS-CoV-2 Sex significant difference significantly higher significantly lower spirometry Still Symptom TNF variable widespread with COVID-19 [DOI] 10.3389/fimmu.2022.837288 PMC 바로가기 [Article Type] Immunology
Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19중증 COVID-19 환자의 렉틴 및 대체 경로를 통한 보완 활성화Immunology Published on 2022-02-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] activate activated Activation Acute kidney injury acute respiratory syndrome addition Alternative pathway alveolar alveolar septa analyzed Autopsy both groups both lungs C1q C3c C5b-9 causes cerebral hemorrhage CFD characterized collateral tissue complement Complement activation complement deposition Control correlated correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokines Defense deposit deposition deregulated died edema Factor followed by hyaline membrane hyaline membranes Immune cell immune cells immune system immunohistochemistry in both groups indicated Inflammatory response Injury investigated involved kidney kidneys lectin lectin pathway Local lung Lung injury Lungs MASP-2 membranes Mortality MPO myeloperoxidase neutrophil Neutrophils occurred Pathogens Patient patients with COVID-19 peritubular capillaries peritubular capillary positive Prevent pro-inflammatory cytokines Pulmonary embolism respiratory SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV-2 virus particle SARS-CoV-2 virus particles semi-quantitative Severe acute respiratory syndrome severe COVID-19 SIGN significantly significantly higher significantly more Spike protein subsequent thrombi tissue damage tissue injury Treatment with COVID-19 worsening [DOI] 10.3389/fimmu.2022.835156 PMC 바로가기 [Article Type] Immunology
Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortalityCOVID-19에서 지속적으로 상승된 보체 대체 경로 바이오마커는 저산소혈증과 상관관계가 있으며 병원 내 사망률을 예측합니다Article Published on 2022-02-012022-09-11 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation Alternative pathway analyzed Biomarker C-reactive protein C5a cause complement Complement activation coronavirus disease Coronavirus disease 2019 correlations COVID-19 COVID-19 patient elevated enzyme enzyme-linked immunosorbent assays Evidence Factor Factor B ferritin healthy control healthy controls Hypoxemia ICU ICU admission IL-6 Immunity in-hospital mortality independent predictor Inflammatory response Innate Innate immunity lectin Level Lung disease marker measure Mortality Multi-organ damage overactivation pathway Patient patient sera predict prospectively studied quantified reduction Respiratory function risk SC5b-9 sera Serum level severely ill COVID-19 patients severity significantly sustained the patient [DOI] 10.1007/s00430-021-00725-2 PMC 바로가기 [Article Type] Article
Distinctive Biomarker Features in the Endotheliopathy of COVID-19 and Septic SyndromesCOVID-19 및 패혈성 증후군의 내피병증에서의 독특한 바이오마커 특징Comparative Study Published on 2022-01-012022-09-11 Journal: Shock (Augusta, Ga.) [Category] 바이오마커, [키워드] Activation ADAMTS adhesion analyzed Biomarker Biomarkers both groups circulating clinical disease collected complement Complement activation contributing to Control COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 group COVID-19 patient COVID-19 patients COVID-19 phenotype COVID-19 pneumonia Critical critical COVID-19 patient critical COVID-19 patients Critically ill critically ill COVID-19 patients Culture disease disease severity dsDNA dysregulation e parameters endothelial Endothelial cell endothelial cells endothelial damage endotheliopathy except for Factor fibrinolysis fibrinolytic healthy donor healthy donors help heparan sulfate Hospitalization ICU in both groups increased expression information intensive care life-threatening mitigate moderate morbidity and mortality motif NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps parameter pathophysiology Patient Phenotypes plasma samples Pneumonia progression receptor Result Sepsis sepsis syndrome septic Septic shock severity of COVID-19 significantly significantly higher significantly lower SIRS Stage Stress sulfate syndrome systemic inflammatory response systemic inflammatory response syndrome therapeutic strategy thrombomodulin TNF volunteers von Willebrand factor vWF was related with COVID-19 [DOI] 10.1097/SHK.0000000000001823 PMC 바로가기 [Article Type] Comparative Study
Eculizumab in patients with severe coronavirus disease 2019 (COVID-19) requiring continuous positive airway pressure ventilator support: Retrospective cohort study지속적인 양압 인공호흡기 지원이 필요한 중증 코로나바이러스 질환 2019(COVID-19) 환자의 에쿨리주맙: 후향적 코호트 연구Observational Study Published on 2021-12-202022-09-12 Journal: PLoS ONE [Category] Coronavirus, MERS, 임상, 진단, [키워드] 95% CI age baseline baseline characteristics blockade change changes in Characteristics cohort study Complement activation Complication complications confirmation contribute Control controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient CPAP creatinine discharge discharged disease dose dysfunction eculizumab Endpoint Ex vivo finding IMPROVE IQR limitation lung dysfunction median Mortality outcome over Patient patients patients died positive airway pressure pressure Primary outcome Randomised controlled trials receiving respiratory rate Result SC5b-9 secondary Secondary outcomes serum creatinine severe coronavirus disease severe COVID-19 Sex significantly small sample size Standard therapy Support thrombi ventilator [DOI] 10.1371/journal.pone.0261113 PMC 바로가기 [Article Type] Observational Study