Pregnancy as a susceptible state for thrombotic microangiopathiesMedicine Review Published on 2024-02-272024-09-05 Journal: Frontiers in Medicine [Category] update2024, [키워드] angiogenesis factors Complement activation Endothelium Kidney biopsy Placental histology Pregnancy thrombotic microangiopathies women [DOI] 10.3389/fmed.2024.1343060 PMC 바로가기 [Article Type] Medicine Review
Immunothrombosis and Complement Activation Contribute to Disease Severity and Adverse Outcome in COVID-19Research Article Published on 2023-11-082024-09-05 Journal: Journal of innate immunity [Category] update2024, [키워드] cell-free DNA Complement activation COVID-19 neutrophil activation thrombosis [DOI] 10.1159/000533339 PMC 바로가기 [Article Type] Research Article
Complement and complement regulatory proteins are upregulated in lungs of COVID-19 patientsArticle Published on 2023-05-082024-09-05 Journal: Pathology, research and practice [Category] update2024, [키워드] Complement activation Complement regulatory protein COVID-19 pathological changes SARS-CoV-2 thrombosis [DOI] 10.1016/j.prp.2023.154519 PMC 바로가기 [Article Type] Article
Association of complement pathways with COVID-19 severity and outcomesRandomized Controlled Trial Published on 2023-05-012023-07-11 Journal: Microbes and infection [Category] COVID19(2023년), [키워드] Complement activation COVID-19 respiratory insufficiency SARS-CoV-2 [DOI] 10.1016/j.micinf.2022.105081 PMC 바로가기 [Article Type] Randomized Controlled Trial
A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce Research Published on 2022-08-112022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, [키워드] activate Activation acute COVID-19 affected Blood C-reactive protein C5a Cluster collected complement Complement activation complex conditions convalescent plasma treatment correlated COVID-19 COVID-19 patients CRP death Deep venous thrombosis demonstrated DVT effector electronic medical records element elevated event HMGB1 homeostasis IgA IgG IgM IL-6 immune response immune system immunological Immunological response incidence Increased Infection Inflammatory response investigated knowledge marker Mortality Necrosis non-specific pathway Patient patients hospitalized PCR-confirmed diagnosis protective factor RAGE remained SARS-COV-2 infection SARS-CoV-2 spike protein shown tissue Treatment viral burden Viral load was collected were assessed [DOI] 10.1038/s41598-022-17011-7 [Article Type] Research
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article
COVID-19 convalescent plasma코로나19 회복기 혈장Article Published on 2022-07-212022-09-11 Journal: Blood [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody-dependent cellular cytotoxicity benefit CCP collected complement Complement activation convalescent plasma coronavirus coronavirus disease COVID-19 disease early disease Efficacy function Health Health crisis high-titer CCP Hospitalized Immunosuppressed immunosuppressed patient immunosuppressed patients indications location moderate moderate to severe Outpatient pandemic phagocytosis plasma prophylactic therapy provide provided randomized trial respiratory safety profile SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe disease symptom onset the patient The United States therapeutic potential Therapies transfused Treatment Trial United States Viral viral neutralization with COVID-19 [DOI] 10.1182/blood.2021012248 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation예방 접종 또는 감염 후 유도된 SARS-CoV-2 스파이크 및 핵단백질 특이적 항체는 고전적 보체 활성화를 촉진합니다Article Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Activation antibodies antibody Antibody responses Antigen binding C1q C1q binding C3b cascade classical classical pathway complement Complement activation Complement cascade complement components Complement pathway component components convalescent COVID-19 COVID-19 patient COVID-19 patients deposition disease status downstream Effect ELISA assay groups hospitalised IgG1 induced median N antigen NHC non-hospitalised non-infected not differ nucleocapsid presence of antibody protective role Protein Protein binding response responses SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera severe COVID-19 specific antigen spike spike glycoprotein subject the disease vaccination Vaccine vaccinees Variability Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.838780 PMC 바로가기 [Article Type] Article
Complement activation in COVID-19 and targeted therapeutic options: A scoping reviewReview article Published on 2022-07-012022-10-05 Journal: Blood reviews [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Activation approach article C5a complement Complement activation Complement cascade complement inhibition Complement pathway Coronavirus disease 2019 correlation COVID-19 disease severity double blind Evidence histopathological Increasing Mortality observational study Pathogenesis RCT review SARS-CoV-2 screened therapeutic [DOI] 10.1016/j.blre.2022.100995 [Article Type] Review article
Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine비활성화된 SARS-CoV-2 백신으로 면역된 건강한 개인의 면역 반응과 관련된 단백질 및 대사체 서명Article Published on 2022-05-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation Adaptive immune response adaptive immune system affected Amino acid amino acids Analysis applied approach Arm Biosynthesis Cohort complement Complement activation CoronaVac COVID-19 dose driving glycine help highlight host response humoral Humoral response identify IgM/IgG immune immune response immune signature Immunity immunization immunized Inactivated vaccine individual innate immune system Interaction mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomics molecular molecular mechanism multifactorial network Phenylalanine proteomics response SARS-CoV-2 SARS-COV-2 infection Serine shown signature Sinovac specific IgM Systems biology TCA cycle threonine Tryptophan tyrosine utility vaccination Volunteer [DOI] 10.3389/fimmu.2022.848961 PMC 바로가기 [Article Type] Article