Radical cancer treatment is safe during COVID-19: the real-world experience of a large London-based Comprehensive Cancer Centre during the first wave Research Published on 2022-07-152022-10-05 Journal: British Journal of Cancer [Category] 임상, 치료법, [키워드] anticancer cancer patient cancer treatment Characteristics Chemotherapy Clinical outcome combination therapy Comprehensive COVID COVID-19 COVID-19 infection COVID-19-related death evaluated First wave hospital Immunotherapy measure outcome pandemic Patient paucity of data positive proportion Radical receive receiving reduced reported Result risk SACT Safe Support therapy treated Treatment [DOI] 10.1038/s41416-022-01909-0 [Article Type] Research
A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug DiscoveryCOVID-19 약물 발견을 위한 잠재적인 납 화합물로서 Andrographis paniculata(Burm. f.) Nees 및 그 구성 요소에 대한 포괄적인 검토Review Published on 2022-07-132022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro activity Andrographis paniculata Anti-inflammatory anti-inflammatory activity Antiviral antiviral activity argument Asian biological properties clinical trial clinical trials Combination complementary Compound Comprehensive Constituent COVID-19 COVID-19 pandemic COVID-19 treatment Critical demonstrated drug Drug discovery early treatment economics Efficacy global health hACE2 Health immunomodulatory immunomodulatory activity in silico in vitro study Infection information ingredient inhibit lead compound Manifestations natural product. pharmacological Placebo Potential Prophylaxis Randomized controlled trial Randomized controlled trials reducing review SARS-CoV-2 severity Side effects Support target protein Treatment treatment for COVID-19 upper respiratory tract upper respiratory tract infection URTI virion production Well-being [DOI] 10.3390/molecules27144479 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanismsSARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다Article Published on 2022-06-202022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Amino acid amino acid changes amino acids analyzed Anti-viral drugs can be used cleave Complete Comprehensive conserved contribute Coronavirus-2 correlated Critical deep mutational scanning deep sequencing defined drug drug design drug resistance Effect effective elicit evade Evolution Evolutionary biology expression functional human population Infectious disease inhibitor inhibitors life cycle M pro main protease mechanism Microbiology Microbiology. MPro Mutation network new strain performed physically protease Protein reduced reveal S. cerevisiae SARS-CoV-2 SARS-CoV-2 main protease selection pressure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Toxicity Vaccines variant viral life cycle Viral resistance virulent yeast [DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article
Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]건강한 개인에서 다양한 COVID-19 백신 조합의 안전성 및 면역원성 평가: 무작위, 피험자 맹검, 대조 3상 시험을 위한 연구 프로토콜 [PRIBIVAC]Article Published on 2022-06-162022-09-11 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 antibodies antibody approval best blood sample Blood samples BNT162b2 boost booster booster dose booster vaccinations cellular Cellular immune response collected Combination Comprehensive control arm Controlled clinical trial CoronaVac country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstration different time point different time points dose Effectiveness Eligible participants Endpoint enrolment evade excluded group healthy Heterologous homologous host immunity humoral immune immune profiling immune response Immunity Immunocompromised immunogenicity Immunoglobulin immunoglobulins Inactivated vaccine Infection Intervention intervention arm Laboratory test Laboratory tests Local maintain mRNA mRNA vaccine mRNA-1273 omicron over parameters participant performed persistence phase Phase 3 phase 3 trial physical population immunity pregnant primary endpoint Probability quantity raising randomization Randomized Randomized controlled trial regimen Regulatory SARS-CoV-2 SARS-COV-2 infection Serious Adverse Event Serious Adverse Events Singapore Study protocol vaccination Vaccine vaccine availability Vaccine booster. vaccine candidate variants variants of concern volunteers wildtype [DOI] 10.1186/s13063-022-06345-2 PMC 바로가기 [Article Type] Article
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics Therapeutics. therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Addressing a critical need for caregiver support in neuro-oncology: development of a caregiver navigation intervention using eSNAP social resource visualizationRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: Supportive Care in Cancer [Category] 임상, [키워드] Brain Brain tumor Care Caregivers collected communication community health Comprehensive COVID-19 Critical Data collection dropped effective engage enrolled Health help identify impacted include Intervention iterative Navigation oncology oncology. outcomes participant Patient physical Preliminary data Psychological qualitative data Randomized receive recruitment resource Support Trial tumors [DOI] 10.1007/s00520-022-06977-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Accuracy of rapid point-of-care antigen-based diagnostics for SARS-CoV-2: An updated systematic review and meta-analysis with meta-regression analyzing influencing factorsSARS-CoV-2에 대한 신속한 현장 진단 항원 기반 진단의 정확성: 영향 요인을 분석하는 메타 회귀 분석을 통한 업데이트된 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-262022-09-11 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval Accuracy acute respiratory syndrome coronavirus Ag-RDT Ag-RDTs Analysis analysis Antigen Asymptomatic Chain Reaction Comprehensive coronavirus 2 Ct-value Ct-values cycle threshold database decrease Descriptive analyses Descriptive analysis detect diagnostics driven by duration of symptom Effect estimate evaluate Factor false False negative heterogeneity high viral load highest in viral individual infected with SARS-CoV-2 information Meta-analysis meta-regression meta-regression models multivariable nasopharyngeal Patient peer-reviewed performed point-of-care polymerase chain polymerase chain reaction positive PROSPERO public health random-effect Random-effects meta-analysis Rapid diagnostic test RDTs Registered registration number respiratory reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 searched sensitivity Sensitivity and specificity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Standardization symptom onset symptom status symptomatic systematic review Testing the mean Viral load virus was used [DOI] 10.1371/journal.pmed.1004011 PMC 바로가기 [Article Type] Meta-Analysis
Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive OverviewSARS-CoV-2 감염 환자의 조절되지 않은 면역 반응: 종합 개요Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus adaptive alteration Antigen antigen-presenting cell antiviral immune responses B cell subset Biomarker caused CD8+ CD8+ T cell cellular cellular immunity complications of COVID-19 Comprehensive comprehensive analysis coronavirus country COVID-19 COVID-19 patients disease effective evade follicular follicular Th cell help Host Human humoral Humoral immunity identify immune responses Immunity IMPROVE Infection Inflammatory information innate and adaptive immunity involved knowledge mechanism molecular mechanism monocyte new virus outcomes pathological change pathological changes Phenotypes post-COVID-19 syndrome. predict recognize Research response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Symptom syndrome T cell Th cell Th cell subsets Th17 the SARS-CoV-2 variety [DOI] 10.3390/v14051082 PMC 바로가기 [Article Type] Review
Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2SARS-CoV-2에 대한 RNA 추출 없는 타액 기반 분자 분석의 종합적인 분석 및 임상 평가Article Published on 2022-05-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition analytical sensitivity clinical evaluation Comprehensive described diagnostic false-negative gold gold standard house individual individuals invasive Laboratory medical staff molecular molecular analysis participated PCR protocol provided repeated RNA RNA extraction RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 testing sensitivity shown specificity Standard Swab swabs testing protocols [DOI] 10.1371/journal.pone.0268082 PMC 바로가기 [Article Type] Article