Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extractsArticle Published on 2024-05-102024-09-05 Journal: Communications Biology [Category] update2024, [키워드] Computational biology and bioinformatics structural biology Virology [DOI] 10.1038/s42003-024-06204-7 PMC 바로가기 [Article Type] Article
Enhancing tuberculosis vaccine development: a deconvolution neural network approach for multi-epitope predictionArticle Published on 2024-05-062024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Computational biology and bioinformatics Drug discovery [DOI] 10.1038/s41598-024-59291-1 PMC 바로가기 [Article Type] Article
Vaccine effectiveness against emerging COVID-19 variants using digital health dataArticle Published on 2024-05-062024-09-05 Journal: Communications Medicine [Category] update2024, [키워드] Computational biology and bioinformatics Diseases [DOI] 10.1038/s43856-024-00508-9 PMC 바로가기 [Article Type] Article
Immunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomerArticle Published on 2024-05-042024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Computational biology and bioinformatics Predictive medicine Protein analysis Protein design Protein structure predictions [DOI] 10.1038/s41598-024-61025-2 PMC 바로가기 [Article Type] Article
Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastasesArticle Published on 2024-04-242024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Cancer Computational biology and bioinformatics genetics immunology Tumour immunology [DOI] 10.1038/s41598-024-60049-y PMC 바로가기 [Article Type] Article
Long-read sequencing and optical mapping generates near T2T assemblies that resolves a centromeric translocationArticle Published on 2024-04-182024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Computational biology and bioinformatics genetics [DOI] 10.1038/s41598-024-59683-3 PMC 바로가기 [Article Type] Article
Immune response stability to the SARS-CoV-2 mRNA vaccine booster is influenced by differential splicing of HLA genesArticle Published on 2024-04-182024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Admixed population Computational biology and bioinformatics genetics human leukocyte antigen Immune response variability immunology Molecular biology SARS-CoV-2 vaccine response whole blood transcriptome [DOI] 10.1038/s41598-024-59259-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 remodels the landscape of small non-coding RNAs with infection time and symptom severityArticle Published on 2024-04-172024-09-05 Journal: NPJ Systems Biology and Applications [Category] update2024, [키워드] Computational biology and bioinformatics Molecular biology SARS-CoV-2 [DOI] 10.1038/s41540-024-00367-z PMC 바로가기 [Article Type] Article
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learningArticle Published on 2024-04-172024-09-05 Journal: Nature chemical biology [Category] update2024, [키워드] Cheminformatics Computational biology and bioinformatics Drug discovery Neurodegenerative diseases Single-molecule biophysics [DOI] 10.1038/s41589-024-01580-x PMC 바로가기 [Article Type] Article
Molecular modelling studies and in vitro enzymatic assays identified A 4-(nitrobenzyl)guanidine derivative as inhibitor of SARS-CoV-2 MproArticle Published on 2024-04-142024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] 3CL Protease Biochemistry Chemical biology Computational biology and bioinformatics coronavirus COVID-19 Drug discovery inhibitors Medical research molecular docking molecular dynamics [DOI] 10.1038/s41598-024-59292-0 PMC 바로가기 [Article Type] Article