Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype OntologyKGEV(Knowledge Graph Exploration and Visualization)용 웹 프레임워크를 통한 신속한 지식 습득: COVID-19 및 인간 표현형 온톨로지에 대한 사례 연구Article Published on 2022-06-022022-09-12 Journal: BMC Medical Informatics and Decision Making [Category] MERS, 진단, [키워드] acquisition computational method computational tool COVID-19 COVID-19 pandemic Data visualization database dataset demonstrated downstream eight emerging disease exploration facilitate filtration FIVE generate heterogenous Human human disease hypotheses information Information extraction knowledge Knowledge discovery Knowledge graph Knowledge graph. lack Metadata phenotypic question reliability Research shortest path Support utility Visualization [DOI] 10.1186/s12911-022-01848-z PMC 바로가기 [Article Type] Article
Phytochemicals-based targeting RdRp and main protease of SARS-CoV-2 using docking and steered molecular dynamic simulation: A promising therapeutic approach for Tackling COVID-19Research article Published on 2022-06-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] affected antiviral drug approved binding binding pocket caused complexes computational tool COVID-19 COVID-19 pandemic docking inhibitor Interaction knowledge Ligand Main proteases mechanism molecular molecular docking molecular dynamic simulation Molecular dynamics simulation MPro mutated phytochemicals protease Protein RdRP RNA-dependent RNA polymerase SARS-CoV-2 Side effect stability Steered dynamic simulation strain suggested targets therapeutic Therapeutic approach therapeutic efficacy Vaccine vaccine candidate virus [DOI] 10.1016/j.compbiomed.2022.105468 [Article Type] Research article
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients통합 멀티오믹스 및 in silico 분석은 경증 및 중증 COVID-19 환자에서 ARHGEF1 및 선별된 길항제의 역할을 밝혔습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anticancer Antiviral ARHGEF1 association Biotechnology caused center co-expression co-expression network Compound computational tool computational tools coronavirus COVID-19 database DEGs determine differentially expressed gene Differentially expressed genes disease effective therapy ENhance enrichment expressed expression profile gene co-expression network Gene ontology group guanine identify in silico analysis In silico methods in vitro in vivo infected patients inherent Medicines messenger Messenger RNA Mild molecular molecular docking molecular dynamics MSI-DEGs nucleotide number of infected Ontology overlapping pathogenic pathway patients worldwide protein-protein interaction rapid increase required Research SARS-CoV-2 SARS-CoV-2 patients screened severe acute respiratory syndrome Coronavirus severe COVID-19 patient Severity of infection stratified target therapeutic drug therapeutic efficacy therapeutic target therapy virus [DOI] 10.1002/jcb.30213 PMC 바로가기 [Article Type] Article
Multiscale PHATE identifies multimodal signatures of COVID-19 Research Published on 2022-02-282022-10-05 Journal: Nature biotechnology [Category] 유전자 메커니즘, 치료법, [키워드] analyzed Cell chromatin Classifier clinical variables Community complex computational tool coronavirus disease COVID-19 dataset diffusion disease feature flow cytometry granularity hospitalized patient identify increasingly neutrophil outcome Patient predict Predictive responses scRNA-seq Sequencing single-cell Single-cell RNA sequencing Th17 Topology [DOI] 10.1038/s41587-021-01186-x [Article Type] Research
Comparative analysis of machine learning-based approaches for identifying therapeutic peptides targeting SARS-CoV-2SARS-CoV-2를 표적으로 하는 치료 펩타이드 식별을 위한 기계 학습 기반 접근 방식의 비교 분석Comparative Study Published on 2022-01-172022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Algorithm Algorithms anticipated Antiviral antiviral peptides approach approaches AVP bioinformatics Comparative analysis computational tool conducted coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical datasets develop disadvantage Disadvantages epitope Epitopes evaluate evaluated evaluation metrics Guidance IL-6 IL-6 inducing peptides impacted in silico independent machine learning peptide peptide-based peptides performance assessment. predictor public health robustness SARS-CoV-2 scalability Scientific community Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus therapeutic [DOI] 10.1093/bib/bbab412 PMC 바로가기 [Article Type] Comparative Study
Identification of transcriptional regulatory network associated with response of host epithelial cells to SARS-CoV-2SARS-COV-2에 대한 숙주 상피 세포의 반응과 관련된 전사 조절 네트워크의 확인Article Published on 2021-12-142022-09-10 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] addition analyses approach BTK change Combination complications of COVID-19 Computational biology and bioinformatics computational tool contribute COVID-19 disease epithelial cell epithelial cells exacerbate Gene Expression Gene regulatory networks Host host cell host cells identification identify Immunity Infection Inflammation involved kinase kinases MAPK14 mechanism mitigate organ damage other respiratory virus Other respiratory viruses pathway Pathways provide reflect Regulation Regulatory regulatory network respiratory SARS-CoV-2 Signaling Systems biology therapeutic target transcriptional virus viruses [DOI] 10.1038/s41598-021-03309-5 PMC 바로가기 [Article Type] Article
Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19COVID-19에 대한 활동을 입증 한 승인 된 약물의 선택과 관련된 독성 위험의 계산 결정Research Published on 2021-10-212022-08-31 Journal: BMC Pharmacology & Toxicology [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach approved approved drug Cardiotoxicity caused clinical assessment clinical trial clinical trials Compound computational tool coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment demonstrated disease drug Drug discovery excretion expected facilitate FIVE global pandemic healthcare in silico independent knowledge majority manuscript metabolism molecules non-toxic off-label Patient pharmacological Practitioner predict profile receive repurposing Repurposing drugs, hERG) researcher respiratory Result risk safety profile SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe pneumonia significantly Spread Stratification supplementary material therapeutic therapeutic agent therapy Toxicity treating COVID-19 Treatment treatment for COVID-19 Usage Vaccine Vaccines [DOI] 10.1186/s40360-021-00519-5 PMC 바로가기 [Article Type] Research
Potential of Marine Terpenoids against SARS-CoV-2: An In Silico Drug Development ApproachArticle Published on 2021-10-202022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 3CL pro acute respiratory syndrome addition analysed Analysis anti-SARS-CoV-2 Antiviral antiviral drug computational tool Coronavirus-2 develop development docking score drug enzyme exhibited Favipiravir genomic HSV-1 in silico Infection M pro marine terpenoids molecular docking performed pharmacological Phylogenetic tree Potential protease RdRP Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 strain selected sequence shown terpenoid toxicity and drug−likeness profiles [DOI] 10.3390/biomedicines9111505 PMC 바로가기 [Article Type] Article
Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approachCOVID-19 발병 기전에서 예측된 SARS-CoV-2 miRNA의 역할 해독: 생물정보학 접근Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Apoptosis apoptotic pathway apoptotic pathways approach bioinformatics computational tool computational tools Coronavirus-2 COVID-19 COVID-19 pathogenesis dataset deregulated down-regulated down-regulated gene e genes enriched pathways function functional enrichment Genes global pandemic Host immune immune responses immune system infected cells infections influence immune responses involved KEGG pathway analysis microRNA miRNA miRNAs modulating molecular mechanism p53 Pathogenesis pathogenicity pathway predicted progression provide regulated Repository SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 miRNA SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling significantly survival target the SARS-CoV-2 transcriptomic profile up-regulated viral miRNA viral miRNAs viral pathogenesis virus [DOI] 10.1016/j.compbiomed.2021.104669 PMC 바로가기 [Article Type] Article
Big Data for Biomedical Education with a Focus on the COVID-19 Era: An Integrative Review of the LiteratureReview Published on 2021-08-262022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] acting articles big data Canada carried challenge China Clinical practice computational tool conducted contribute COVID-19 curriculum database datasets determinant DNA duplication education Effectiveness ENhance equity European facilitate FIVE focus France Germany IMPROVE Inclusion information integrative review Italy knowledge literature literature review medical education methodology MONITOR nine North overcome pandemic performed Perspective Practitioner professional professionals promote proteomics Research retrieved review transcriptomics translational USA while [DOI] 10.3390/ijerph18178989 PMC 바로가기 [Article Type] Review