COVID-19(22) SARS-CoV-2(20) acute respiratory syndrome coronavirus(19) acute respiratory syndrome(19) molecular(16) severe acute respiratory syndrome Coronavirus(15) coronavirus(14) Infection(14) the spike protein(12) Spike protein(12) pathway(10) acute respiratory syndrome coronavirus 2(10) angiotensin(10) ACE2(10) RBD(10) the SARS-CoV-2(9) Analysis(8) Mutation(8) angiotensin-converting enzyme 2(7) receptor(7) Contact(7) RBD residue(7) the receptor-binding domain(7) Angiotensin-converting enzyme(7) virus(7) Receptor-binding domain(7) complex(7) reduce(7) molecular dynamics(7) free energy(7)