Abstract
Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid-19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid-19 therapeutics that are known for their dampening effect on the immune system. Thus, the underlying concept of selecting these drugs is to temper the potentially life-threatening overshooting of the immune system reacting to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This viewpoint discusses the possibility that the impact of these and other drugs on autophagy contributes to their therapeutic effect by hampering the SARS-CoV-2 life cycle.
Keywords: Covid-19; SARS-CoV2; autophagy; drug repurposing; pharmacology; virophagy.
【저자키워드】 COVID-19, Drug repurposing, SARS-CoV2, Pharmacology, autophagy, virophagy, 【초록키워드】 coronavirus disease, Drug repurposing, SARS-CoV-2, Coronavirus disease 2019, pandemic, Infection, severe acute respiratory syndrome coronavirus-2, drug, Pharmacology, immune system, severe acute respiratory syndrome Coronavirus, autophagy, COVID-19 therapeutics, Severe acute respiratory syndrome, respiratory, Coronavirus-2, Health Organization, life cycle, World Health Organization, acute respiratory syndrome, Treatment strategies, acute respiratory syndrome coronavirus, SARS-CoV-2 life cycle, acute respiratory syndrome coronavirus-2, therapeutic effect, contribute, potentially life-threatening, temper, the SARS-CoV-2, 【제목키워드】 effort,