Neurological and Neuropsychological Changes Associated with SARS-CoV-2 Infection: New Observations, New MechanismsReview Published on 2022-12-012023-07-06 Journal: The Neuroscientist : a review journal bringing neurobiology, neurology and [Category] COVID19(2023년), [키워드] angiotensin ARDS autoantibodies COVID-19 Encephalitis Inflammation neurodegeneration pandemic SARS stroke Viral infection. [DOI] 10.1177/1073858420984106 PMC 바로가기 [Article Type] Review
Evidence for Interplay Between the Renin-Angiotensin System and Toll-Like Receptor 4 Signaling Pathways in the Induction of Virus-Induced Acute Lung InjuryArticle Published on 2022-12-012023-07-10 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), [키워드] ACE2 ALI angiotensin Inflammation macrophages. RAS S protein SARS-CoV2 TLR4 [DOI] 10.1089/jir.2022.0081 PMC 바로가기
Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid Thyroid. tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2. sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article
Mechanisms of COVID-19 pathogenesis in diabetes당뇨병에서 COVID-19 발병 기전의 메커니즘Review Published on 2022-09-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 cardiovascular cardiovascular disease caused Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pathogenesis Cytokine storm diabete diabetes Disease progression Effect enzyme global pandemic heart failure Host host cell host cells hypertension Inflammation Inflammation. mechanism multiorgan failure Mutation outcomes Patient receptor receptors resulting risk of infection SARS-CoV-2 SARS-CoV-2 spike proteins severe acute respiratory syndrome Coronavirus therapeutic approaches variety virus [DOI] 10.1152/ajpheart.00204.2022 PMC 바로가기 [Article Type] Review
The basis of mink susceptibility to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 밍크 감수성의 근거Review Published on 2022-09-012022-09-11 Journal: Journal of applied genetics [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals B.1.1.7 B.1.617.1 B.1.617.2 coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Cross-species infection Cross-species transmission D614G death rate disease Evolution highest Host host range Human humans Infection interact issue Minks Mutation Occurrence over Pathogens phenomenon possession Protein raise RBD receptor Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sequence Sequence alignment spike Spike protein spike protein. susceptibility the receptor-binding domain Transmission variants Viral diseases viral pathogenesis viral pathogens virus Y453F [DOI] 10.1007/s13353-022-00689-w PMC 바로가기 [Article Type] Review
A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmesSARS-CoV-2에 대한 척추동물 감수성 식별을 위한 새로운 구조 기반 접근 방식: 미래 감시 프로그램에 대한 의미Article Published on 2022-09-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity conservation contribute coronavirus Critical Cross-species transmission debatable dissociation Dissociation constant domain facilitate facilitated genetic determinant genetic determinants highlight Host host cell host cell receptor host cells host range hosts in vivo Intensive interacting residue Interaction isoform Ligand mechanism molecular interaction Outbreaks Pathogens Prevent profile Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Scientific community severe acute respiratory syndrome Coronavirus spike Spike protein Surveillance susceptibility susceptible the SARS-CoV-2 understanding Vertebrate Vertebrate species. viral evolution virus entry zoonotic pathogens [DOI] 10.1016/j.envres.2022.113303 PMC 바로가기 [Article Type] Article
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19COVID-19로 입원한 남성의 개선된 결과와 관련된 레닌-안지오텐신 시스템 경로 치료제Observational Study Published on 2022-09-012022-09-11 Journal: Critical Care Medicine [Category] 유전자 메커니즘, 임상, [키워드] ACE ACE inhibitor ACE inhibitors ACE-2 ACE2 gene acute COVID-19 acute COVID-19 illness acute respiratory syndrome acute respiratory syndrome coronavirus adjusted odds ratio Admission Analysis angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme ARB ARBs baseline baseline characteristics cohort of patient Comorbidities component components contribute coronavirus COVID-19 COVID-19 illness d -dimer determine downregulate dysregulation Effect explain female females hospital Hospitalized hospitalized patient hospitalized patients Improved include inhibitor inhibitors Interaction less male measurement Mortality multicenter Observational cohort study organ support outcome outcomes Patient plasma polymerase chain polymerase chain reaction pro-inflammatory Prospective RAS recorded Renin renin-angiotensin system response severe acute respiratory syndrome Coronavirus Sex Sex-related differences significant effect significantly significantly higher System Therapeutics Treatment Vasopressor vasopressors Ventilation with COVID-19 X chromosome [DOI] 10.1097/CCM.0000000000005589 PMC 바로가기 [Article Type] Observational Study