Conformational variability of loops in the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질 루프의 구조적 가변성Article Published on 2022-03-012022-09-11 Journal: Proteins [Category] SARS, 변종, [키워드] Accuracy Analysis applied binding Characteristics Cluster cluster analysis conformation conformational conformational ensembles conformations COVID-19 decoy selection facilitate flexible identify involved loop loop modeling Protein Protein binding Protein Data Bank protein structure protein structure prediction Region SARS-CoV-2 spike sequence sequence variants. Spike protein structures targets the S protein the SARS-CoV-2 Variability variants viral infection while [DOI] 10.1002/prot.26266 PMC 바로가기 [Article Type] Article
Analysis of the Neutralizing Activity of Antibodies Targeting Open or Closed SARS-CoV-2 Spike Protein ConformationsArticle Published on 2022-02-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 activity analyzed binding binding affinity binding affinity prediction circulating complex conformation conformations contribute COVID-19 domains elicit elicited enzyme Epitopes escape fractions fraction Fractions immune response immunodominant immunogens immunoinformatics in silico infected patients information inhibit mRNA-1273 NAb neutralizing antibody Patient plasma polyclonal polyclonal plasma pre-fusion predict predicted Prevent SARS-CoV-2 SARS-COV-2 infection spike Spike protein Spike protein variants Strains Structure suggested target targeting the spike protein to define trajectory trimer Vaccine Vaccines variant virus [DOI] 10.3390/ijms23042078 PMC 바로가기 [Article Type] Article
Unravelling the molecular interactions between the SARS-CoV-2 RBD spike protein and various specific monoclonal antibodiesSARS-CoV-2 RBD 스파이크 단백질과 다양한 특정 단일클론항체 간의 분자 상호작용 규명Article Published on 2022-02-012022-09-12 Journal: Biochimie [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accelerated Accelerated molecular dynamics ACE2 ACE2 receptor approach cell receptor conformation Conformational study conformations COVID-19 disease CR3022 determine drugs epitope identify increase Interaction knowledge mAb mAbs molecular molecular interaction monoclonal antibody physiological conditions predominant protein-protein interaction RBD Result S protein S309 Salt Bridge SARS-CoV-2 spike glycoprotein Spike protein the RBD the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic option treat Vaccine virus [DOI] 10.1016/j.biochi.2021.10.013 PMC 바로가기 [Article Type] Article
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms스파이크 당단백질에 대한 헤파린의 결합은 세 가지 메커니즘에 의해 SARS-CoV-2 감염을 억제합니다Article Published on 2022-02-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity antiviral agent antiviral therapy assays bind binding biochemical cleavage competing conformation conformations coronavirus COVID-19 derivative docking experiment facilitate furin glycoprotein glycosaminoglycan heparan sulfate heparin hinge region homotrimer Host host cell host cell receptor inactive induce Infection inhibit inhibit SARS-CoV-2 investigated mechanism molecular molecular dynamics molecular dynamics simulations motion multifunctional N-terminal domain opening Proteoglycan RBD Receptor-binding domain residue responsible S1/S2 site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein SARS-CoV-2 virus SARS-CoV-2 virus spike (S) severe acute respiratory syndrome Coronavirus spike glycoprotein subunit sulfate the RBD the receptor-binding domain the SARS-CoV-2 viral infection virus [DOI] 10.1016/j.jbc.2021.101507 PMC 바로가기 [Article Type] Article
Multiple conformations of trimeric spikes visualized on a non-enveloped virusArticle Published on 2022-01-272022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, 치료제, [키워드] ATP C-terminal C-terminal domain cascade cellular membrane conformation conformations Cryoelectron microscopy cytoplasmic cytosolic domain host cells insertion Integrins membrane monomer Multiple N-terminal N-terminal domain Reoviridae RNA S-adenosylmethionine SAM spikes Structure Transcription Trigger triggered trimeric trimeric spike viral infection virus Virus structures [DOI] 10.1038/s41467-022-28114-0 PMC 바로가기 [Article Type] Article
Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses박쥐와 인간 코로나바이러스 ORF8 단백질 Ig-유사 도메인의 결정 구조는 면역 반응의 다양성에 대한 통찰력을 제공합니다Immunology Published on 2021-12-172022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, 변종, [키워드] accessory protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assays bat biochemical biological function Biological functions CD14 Characteristics Combined conditions conformations coronavirus COVID-19 crystal crystal structure crystal structures Crystallography Disulfide Diversity domain Effect human coronavirus human peripheral blood immune immune responses in vitro insight Interaction interfere isoforms monocyte Monocytes Mutagenesis ORF8 ORF8 protein ORF8 proteins Peripheral blood Protein RaTG13 residue respiratory response responsible RNA genome SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure subsequent the epidemic variant Viral [DOI] 10.3389/fimmu.2021.807134 PMC 바로가기 [Article Type] Immunology
Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding PocketArticle Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Analysis arginine residue binding pocket circulating clades conformations ENhance Evolution evolutionary relationship expressed furin furin cleavage furin cleavage site greater highlight human host Improving Interaction investigated involved Italy Lineage molecular molecular dynamics mutant Mutation new SARS-CoV-2 performed Phylogenesis Phylogenetic pocket polar predicted Prevalence proteolytic Q675H spike mutation role SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage shown spike spike mutation Spike protein viral entry viral fitness Viral protein VoC VOCs [DOI] 10.3390/v13122511 PMC 바로가기 [Article Type] Article
DINC-COVID: A webserver for ensemble docking with flexible SARS-CoV-2 proteinsResearch article Published on 2021-12-012022-10-05 Journal: Computers in biology and medicine [Category] 유전자 메커니즘, [키워드] addition binding affinities binding energy binding mode conformation conformations correlation COVID-19 COVID-19 pandemic crystallographic structure dataset docking effective inhibitor effort Ensemble docking flexible highlight in silico inhibitor inhibitors Ligand ligands molecular molecular docking molecular dynamics platform producing Protein Protein Data Bank provide receptor Receptor flexibility Research resolved SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins shown temperature tested Virtual screening [DOI] 10.1016/j.compbiomed.2021.104943 [Article Type] Research article
Exposing structural variations in SARS-CoV-2 evolutionSARS-CoV-2 진화의 구조적 변이 노출Article Published on 2021-11-112022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] ACE2 acute disease Affect affinity aligned Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 conformational change conformations contributed coronavirus Course Critical delta variant disease effective Effectiveness Evolution function human cells integration lack Lineage Lineage B.1.1.7 Mutation mutations Physicochemical properties physicochemical property physiochemical property Protein protein sequence protein structure residue SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variants Spike protein Structural analysis structural biology Structural variation structural variations Structure structures the SARS-CoV-2 Vaccine variant Viral viral infection virus Virus evolution [DOI] 10.1038/s41598-021-01650-3 PMC 바로가기 [Article Type] Article
The Antiviral Activity of Bacterial, Fungal, and Algal Polysaccharides as Bioactive Ingredients: Potential Uses for Enhancing Immune Systems and Preventing VirusesNutrition Published on 2021-11-052022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activity addressed adjuvants Anti-inflammatory antioxidant Antiviral antiviral activity antiviral properties Bacteria biological activities conformations COVID-19 drug Enhancing evaluated exhibited Factor food functional fungi groups healthy human diseases immune immune response immune system immunomodulation immunomodulatory activities Infection infections inhibit mechanism mechanisms microbe microbial microorganisms modulate molecular molecular weight polysaccharide Potential Prevent Preventing public health Safe SARS-CoV-2 SARS-COV-2 infection Spread sulfated polysaccharides System viral infections virus [DOI] 10.3389/fnut.2021.772033 PMC 바로가기 [Article Type] Nutrition