Conjugation with 8-arm PEG and CRM 197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein8-arm PEG 및 CRM 197과의 접합은 SARS-CoV-2 ORF8 단백질의 면역원성을 향상시킵니다Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] activate adjuvant adjuvants aluminum antigens BALB/c mice carrier protein cellular conjugate Conjugates conjugation COVID-19 pandemic CRM(197) cytokine Cytokines effective effective vaccine Effective vaccines Effectiveness eight-arm PEG. ENhance evaluated expected functions humoral immune response IFN-β IFN-γ IgG IL-5 immune protection immune response immune responses immunogenicity IMPROVE inherent inhibit liver multiple antigen ORF8 ORF8 protein proliferation promoter Protein raise renal SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine SARS-CoV-2 variants splenocyte T helper cell T helper cells the SARS-CoV-2 TNF-α Toxicity Vaccine Vaccines variant [DOI] 10.1016/j.intimp.2022.108922 PMC 바로가기 [Article Type] Article
In-silico study for the screening and preparation of ionic liquid-AVDs conjugate to combat COVID-19 surgeResearch article Published on 2022-08-012022-10-05 Journal: The British journal of oral & maxillofacial surger [Category] 변종, 신약개발, 치료제, [키워드] abacavir acyclovir ADME Analysis Antiviral antiviral activity antiviral drug antiviral drugs binding energy blind caused Combination combination therapy complex conjugate Conjugates COVID-19 death DFT Diseases drug effective greater Ionic liquids MD simulation molecular molecular docking MPro pandemic performed protease recorded SARS-CoV-2 screened stability suggested target protein therapeutic Toxicity was done were used [DOI] 10.1016/j.molliq.2022.119277 [Article Type] Research article
Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme: Open label phase I and phase IIa clinical trials동종 또는 이종 체계에서 항 SARS CoV-2 백신 SOBERANA 02의 안전성 및 면역원성: 공개 라벨 임상 1상 및 2a상 임상 시험Clinical Trial Published on 2022-07-292022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adaptive adverse event Anti-RBD IgG Antigen clinical trial clinical trials conjugate Conjugate vaccine COVID-19 COVID-19 vaccine D614G delta variant dose doses elicited ELISA evaluate evaluated frequencies Frequency hACE2 Heterologous heterologous immunization Heterologous immunization scheme homologous homologous or heterologous IgG IgG ELISA IIa immune response immune responses immunogenic immunogenicity Immunological response Interaction local pain molecular neutralization neutralized Neutralizing antibodies neutralizing antibody Open-label outcome Panel performed phase Phase I phase IIa Primary outcome progressed protocol protocols RBD receive receiving reduction reported Safe Safety SARS-CoV-2 secondary outcome selected Specific T-cell response subjects Subunit vaccine T-cell T-cell Response T-cells Tetanus tetanus toxoid trials Vaccine variant Volunteer volunteers [DOI] 10.1016/j.vaccine.2022.05.082 PMC 바로가기 [Article Type] Clinical Trial
Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccinesResearch article Published on 2022-07-092022-10-05 Journal: iScience [Category] 비임상, [키워드] Antigen binding collected conjugate Conjugates crosslinked demonstrated domain effective Efficacy ENhance functional generate hACE2 immunology isolate mice pandemic persist Protein Pseudovirus neutralization assays RBD SARS-CoV-2 SARS-CoV-2 vaccine sera Th1 Vaccine variant variants Virology [DOI] 10.1016/j.isci.2022.104739 [Article Type] Research article
Adjuvant-Protein Conjugate Vaccine with Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV-2 and Variants of ConcernS1에 TLR7 작용제가 내장된 아주반트-단백질 접합 백신은 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다Article Published on 2022-07-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] adjuvant adjuvant-protein conjugate agonist Alpha Antigen B.1.1.529 Beta cellular immunity Cluster concern conjugate Conjugates coronavirus disease COVID-19 disease Diseases Effect effective expected facilitate global pandemic humoral immune immune response induce mice Neutralizing antibodies neutralizing antibody New coronavirus omicron potent Prevent Protein recombinant protein vaccine. Research S1 protein S1 subunit Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein the vaccine TLR7 TLR7 agonist Toxicity triggered Vaccine vaccine candidate variants of concern [DOI] 10.1021/acsinfecdis.2c00259 PMC 바로가기 [Article Type] Article
Silent Antibodies Start Talking: Enhanced Lateral Flow Serodiagnosis with Two-Stage Incorporation of Labels into Immune ComplexesSilent Antibodies Start Talking: 면역 복합체에 라벨을 2단계 통합하여 향상된 측면 흐름 혈청 진단Article Published on 2022-06-212022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] added antibody Antigen applied approach binding Blood carried coloration complexes conjugate coronavirus COVID-19 demonstrated diagnostic diagnostic sensitivity diagnostic specificity enhanced false-negative false-negative results first stage Flow gold Gold nanoparticle Immune complexes immunochromatographic immunochromatography Immunoglobulin immunoglobulins incorporation increase in intensity lAbel Lateral lateral flow immunoassay LFIA magnitude membrane non-specific pathogen pathogen-specific Protein protein A RBD RBD protein recombinant RBD protein reduction risk SARS-CoV-2 separated serodiagnostic specific antibodies specificity staphylococcal test strip test strips. The diagnostic sensitivity variant zone [DOI] 10.3390/bios12070434 PMC 바로가기 [Article Type] Article
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Research Published on 2022-06-022022-10-05 Journal: Nature biotechnology [Category] Coronavirus, 진단, [키워드] administration Alzheimer’s disease amyloid precursor protein approved Cell cell types Central nervous system CNS conjugate Efficacy evaluated hepatocyte intranasal intravitreal knockdown liver lung non-human primate organs physiological Region resulting RNA RNA interference rodent Safe siRNA siRNAs specificity sustained target gene therapeutic Therapeutics tissue [DOI] 10.1038/s41587-022-01334-x [Article Type] Research
Increase of Macrolide-Resistance in Streptococcus pneumoniae Strains After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Lima, Peru페루 리마에서 13가 폐렴구균 결합백신 도입 후 Streptococcus pneumoniae 균주에서 Macrolide 내성 증가Article Published on 2022-05-092022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, 폐렴구균 감염증, [키워드] 13-valent pneumococcal conjugate vaccine 2019 Azithromycin carriage children collected conducted conjugate COVID-19 COVID-19 pandemic cross-sectional study evaluate Evolution FIVE Frequency Future healthy healthy carrier immunization program increase increasingly introduced invasive invasive pneumococcal disease isolate Macrolide macrolide-resistance mechanism Nasopharyngeal swab nasopharyngeal swabs PCR Pediatric patient Pediatric patients pneumococcal pneumococcal conjugate vaccine Pneumonia pneumoniae Program resistance gene respiratory infections S. pneumoniae screened serotype significant decrease significant increase strain Strains Streptococcus Streptococcus pneumoniae treated Treatment upper respiratory infection Vaccine [DOI] 10.3389/fcimb.2022.866186 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech)SARS-CoV-2 스파이크 잔기 616/644 및 1138/1169는 COVID-19 mRNA COMINARTY 백신에서 2개의 항체 에피토프를 나타냅니다(화이자/바이오엔텍)Article Published on 2022-04-092022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody epitope Antibody Response Antigen B-cell epitope BALB/c mice conjugate contribute coronavirus SARS-CoV-2 COVID-19 COVID-19 mRNA vaccines COVID-19 recovered patients COVID-19 vaccine COVID-19 vaccines effective Efficacy effort ELISA assay full-length identify immune immunogenic individuals linear B-cell epitope mRNA peptide peptide-based performed Pfizer-BioNTech Pfizer/BioNTech Protective question raise recipient residue responsible SARS-CoV-2 spike SARS-CoV-2 spike protein sera the SARS-CoV-2 the spike protein Vaccine worldwide pandemic [DOI] 10.1038/s41598-022-10057-7 PMC 바로가기 [Article Type] Article
Capability of novel fluorescence DNA-conjugated CdTe/ZnS quantum dots nanoprobe for COVID-19 sensingCOVID-19 감지를 위한 새로운 형광 DNA 접합 CdTe/ZnS 양자점 나노프로브의 기능Article Published on 2022-03-152022-09-11 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] CdTe/ZnS quantum dots complementary Complementary DNA Concentration conditions conjugate COVID-19 Covide-19 virus DNA energy transfer fluorescence intensity FRET infected patient infected patients linear linear equation mixture Nanosensor Nanosensor. outcome positive control R 2 Regression replacing RNA RT-PCR Saliva thioglycolic acid was determined [DOI] 10.1016/j.saa.2021.120702 PMC 바로가기 [Article Type] Article