Using a Systems Approach to Explore the Mechanisms of Interaction Between Severe Covid-19 and Its Coronary Heart Disease ComplicationsCardiovascular Medicine Published on 2022-02-162022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] activate aggravate approach association cardiovascular comorbidities cardiovascular complication cardiovascular disease CHD chronic cardiovascular Comorbidities Complete Complication complications computational analysis Coronary Coronary heart disease COVID-19 death disease severity Endothelial cell Factor FIVE hallmark Health heart help hypercholesterolemia hypoxia include inhibitors Injury Interaction investigated mechanism mechanisms nine occur Pathogenesis pathogenic pathway Patient patients pharmaceutical intervention recommendation Research resulting risk SARS-CoV-2 Seven severity smoking spiral Stress suppress System systems-approaches thrombin β-blockers [DOI] 10.3389/fcvm.2022.737592 PMC 바로가기 [Article Type] Cardiovascular Medicine
The Association of Low Molecular Weight Heparin Use and In-hospital Mortality Among Patients Hospitalized with COVID-19Observational Study Published on 2022-02-012022-10-05 Journal: Cardiovascular Drugs and Therapy [Category] 임상, [키워드] 95% CI adjusted adjusted odds ratio age Analysis association benefit CHD conducted Coronary heart disease COVID-19 Critically ill D-dimer demonstrated determine diabetes Elderly patient enrolled had more heparin hospital hospitalized COVID-19 patients hypertension IL-6 in-hospital mortality in-hospital mortality rate Inflammatory cytokine IQR limit LMWH LMWH. low molecular weight median age men Mortality mortality risk Older parameter Patient patients with COVID-19 Primary outcome Retrospective study severe COVID-19 severely ill patients survival treated weight with COVID-19 Wuhan, China [DOI] 10.1007/s10557-020-07133-3 PMC 바로가기 [Article Type] Observational Study
Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity유전자 연관성 데이터의 소음-증류 방향성 클러스터링Research Article Published on 2022-01-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting applied approach approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants [DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article
Clinical Characteristics, Outcomes, and Risk Factors of Disease Severity in Patients With COVID-19 and With a History of Cerebrovascular Disease in Wuhan, China: A Retrospective StudyNeurology Published on 2022-01-112022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome Admission adverse outcome adverse outcomes age albumin analyses Analysis analyzed Blood urea nitrogen C-reactive protein cerebrovascular Cerebrovascular disease chronic obstructive clinical Clinical characteristics clinical feature Clinical outcome clinical study Comorbidities confirmed case confounding effect consecutive patient Coronary heart disease coronavirus Coronavirus disease 2019 COVID-19 CVD death Decreased diabetes difference event Factor higher risk history Hospitalization Huoshenshan Hospital hypertension incidence intensive care investigated lactate dehydrogenase lymphocyte Lymphocyte count mechanical ventilation multivariate logistic regression neutrophil Odds ratio Older pandemic Patient patients with COVID-19 propensity score matching pulmonary disease retrospective risk factor Risk factors Sex Shock single-center smoking two group White blood cell Wuhan [DOI] 10.3389/fneur.2021.706478 PMC 바로가기 [Article Type] Neurology
Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV StudyCardiovascular Medicine Published on 2021-11-302022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute COVID-19 age Analysis Care chest pain clinical status Coronary heart disease COVID 19 COVID-19 COVID-19 disease COVID-19 patient COVID-19 symptoms cross-sectional determine diabetes Diagnosis disease dysfunction Effect endothelial Endothelial dysfunction endothelial function Endothelium female gender hypertension independent risk factor Infection Injury insight large cohort Long Long COVID-19 syndrome Microcirculation multicenter observational study need for oxygen Patient patients Polymath recruitment severity Sex significantly Symptom Symptoms syndrome Vascular endothelium [DOI] 10.3389/fcvm.2021.745758 PMC 바로가기 [Article Type] Cardiovascular Medicine
Cohort study of the characteristics and outcomes in patients with COVID-19 and in-hospital cardiac arrestObservational Study Published on 2021-11-292022-10-04 Journal: BMJ Open [Category] Fulltext, MERS, SARS, 임상, [키워드] 95% CI adult cardiology age Cardiology Cardiopulmonary cause Characteristics clinical condition condition Coronary heart disease COVID-19 displaying hypoxia In-hospital Infection measure objective outcome outcomes pandemic participant Patient patients with COVID-19 predictor prevalence of COVID-19 proportion receiving registry Result Resuscitation second wave survival Swedish women [DOI] 10.1136/bmjopen-2021-054943 PMC 바로가기 [Article Type] Observational Study
Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non- ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, IndonesiaResearch Article Published on 2021-11-292022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] age Analysis and well-being average Chronic kidney disease Coagulation coagulation parameter Coagulation parameters Coagulopathy comorbid Coronary Coronary heart disease COVID-19 COVID-19 case COVID-19 patient COVID-19 patients CRP D-dimer death Deceased decrease Diabetes Mellitus disease East good health hematologic hematology hospital ICU Increases independent Indonesia Isolation room lymphocyte lymphocyte counts majority moderate Mortality neutrophil NLR parameter parameters Patient positive predict Research Result retrospective risk factor severe COVID-19 patient significantly single-center study survival tested the disease treated WBC White blood cell [DOI] 10.12688/f1000research.53803.3 PMC 바로가기 [Article Type] Research Article
Association of cardiac injury with hypertension in hospitalized patients with COVID-19 in China중국에서 COVID-19를 가진 입원 환자의 고혈압과 심장 손상의 연관Article Published on 2021-11-172022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, [키워드] acute respiratory distress acute respiratory distress syndrome addition Analysis analyzed association bilateral pneumonia blood pressure brain natriuretic peptide C-reactive protein cardiac injury cardiac injury marker cardiac injury markers caused Cerebrovascular disease China Chronic kidney disease CK-MB collected Comorbidities Comorbidity Coronary heart disease coronavirus disease Coronavirus disease 2019 correlated Correlation analysis COVID COVID-19 COVID-19 patients creatine creatine kinase CRP demographic demographic data demonstrated diabetes disorder elevated erythrocyte sedimentation erythrocyte sedimentation rate evaluated exhibited global pandemic heart disease higher risk Hospitalization hospitalized patient hypertension hypertensive hypertensive patient hypertensive patients hypoproteinemia IMPROVE increase in Injury Kidney disease Laboratory laboratory findings lactic dehydrogenase LDH moderate morbidity and mortality Myoglobin Older Patient patients peptide phenotype Pneumonia Prognosis respiratory distress sedimentation rate severe disease significantly significantly increased suggested syndrome Systolic blood pressure variables with COVID-19 [DOI] 10.1038/s41598-021-01796-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection and cardiovascular or pulmonary complications in ambulatory care: A risk assessment based on routine dataObservational Study Published on 2021-10-212022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] Accuracy adjusted age Care CHD Chronic kidney disease chronic obstructive CKD Cohort cohort study complex COPD Coronary heart disease Dementia excluded Factor Germany Health help high risk hospital hypertension Hypothesis identify investigated multivariable obesity Odds ratio participant Patient PCR PCR test physician Pneumonia polymerase chain positive positive PCR test prognostic pulmonary complication pulmonary complications pulmonary disease receive Regression model Result risk risk factor Risk factors SARS-COV-2 infection sensitivity severe COVID-19 Significant significantly specificity type 2 diabete were used [DOI] 10.1371/journal.pone.0258914 PMC 바로가기 [Article Type] Observational Study
Association between renin-angiotensin system inhibitors and COVID-19 complicationsObservational Study Published on 2021-09-212022-10-05 Journal: European heart journal. Cardiovascular pharmacothe [Category] SARS, 임상, [키워드] 95% confidence interval Admission Analysis Associated factors association baseline characteristics of patient clinical trial complications of COVID-19 composite endpoint Coronary heart disease Course COVID-19 COVID-19 complication Critical Critical outcomes death died Disease progression Factor France higher risk Hospitalized hospitalized patient ICU ICU admission identify inhibitor inhibitors intensive care IQR laboratory-confirmed Local median median age medication multivariable logistic regression not differ Odds ratio outcome outcomes Patient patients treated positive primary composite endpoint renin-angiotensin system renin–angiotensin system Renin–angiotensin system inhibitors. risk SARS-CoV-2 severe COVID-19 subset tested the disease the primary endpoint treated university hospital variables were used widespread with COVID-19 [DOI] 10.1093/ehjcvp/pvaa062 PMC 바로가기 [Article Type] Observational Study