Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody responseArticle Published on 2022-12-132023-07-11 Journal: Cell Reports [Category] COVID19(2023년), [키워드] antibodies COVID-19 CP: Immunology glycosylation SARS-CoV-2, IgG, RBD, Nucleocapsid, vaccination, infection, neutralization, inflammation [DOI] 10.1016/j.celrep.2022.111799 PMC 바로가기
Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Article Published on 2022-11-152023-07-10 Journal: Cell Reports [Category] COVID19(2023년), [키워드] allelic preference broadly neutralizing COVID-19 CP: Immunology CP: Microbiology Data mining public antibody SARS-CoV-2 Sequence analysis variants of concern [DOI] 10.1016/j.celrep.2022.111650 PMC 바로가기
Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variantsArticle Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] Analysis antibodies antibody Beta breadth complementary conserved CP: Immunology CP: Microbiology Efficacy Hamster model human monoclonal antibodies immune Immune escape in vivo interact monoclonal antibody mutations neutralization neutralize Neutralizing activity omicron Omicron sublineages BA.1., BA.2, BA.2.12.1, and BA.4 overcome potent Protective provide raise reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein Spread the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic efficacy Vaccine variant variants variants of concern [DOI] 10.1016/j.celrep.2022.111528 PMC 바로가기
A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two dosesArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administering boost caused coronavirus COVID-19 CP: Immunology Donor dose elicit elicited extended interval humoral Humoral response humoral responses individual Infection long interval mRNA vaccine observé omicron regimen robust SARS-CoV-2 SARS-CoV-2 BNT162b2 second dose significantly spike glycoproteins third mRNA vaccine dose vaccinated individuals variant variants of concern VoC VOCs [DOI] 10.1016/j.celrep.2022.111554 PMC 바로가기
BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with ageArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome addition age antibody Antibody glycosylation BNT162b2 mRNA vaccine breadth coronavirus COVID-19 CP: Immunology disease domain dose Efficacy Fab Fc effector functions Fc function Fc receptor FIVE function functions greater immune cells Immunity individual induce Infection isolate magnitude neutralization neutralize Neutralizing Neutralizing activity non-neutralizing antibody omicron polyclonal antibody populations promote provide response SARS-CoV-2 SARS-CoV-2 variants sera uninfected Vaccine vaccine-specific antibodies variant variants virus wild-type [DOI] 10.1016/j.celrep.2022.111544 PMC 바로가기
SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinationsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody antigenic assays boost coronavirus CP: Immunology cross-react determine elicit Health care worker human coronavirus human coronaviruses Infection magnitude mRNA mRNA vaccination mRNA vaccines original antigenic sin participant proportion reactive responses SARS-CoV-2 SARS-COV-2 infection specificity vaccination [DOI] 10.1016/j.celrep.2022.111496 PMC 바로가기
Reduced B cell antigenicity of Omicron lowers host serologic responseArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response Antibody titer antigenicity B cell Breakthrough infection common cold coronavirus computational structural biology conserved CP: Immunology CP: Microbiology cross-reactivity deep learning ELISA Epitopes evade explain feature geometric Host Infection less Lower mechanism Mice immunization experiment mutated Neutralizing omicron Omicron variant of concern RBD RBS Receptor binding Receptor binding domain receptor binding site reduced reduction reduction in reveal SARS-CoV-2 Serologic response serological response serum Spike protein trajectory vaccine-induced antibody variant variants viral evolution [DOI] 10.1016/j.celrep.2022.111512 PMC 바로가기
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination상피 HIF 매개 외래 식세포작용이 살모넬라 감염 및 전파 조절에 필수적인 역할Article Published on 2022-09-272024-08-22 Journal: Cell Reports [Category] 살모넬라증, [키워드] autophagy chromatin immunoprecipitation Colitis colonoid CP: Immunology CP: Microbiology hypoxia Inflammation Innate immunity mucosa neutrophil Transcription
A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donorArticle Published on 2022-09-132022-11-15 Journal: Cell Reports [Category] SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 antibodies antibody antibody repertoire Bioactivity characterized contribute CP: Immunology deep sequencing developmental Donor early infection elicit event facilitate immunogen information Lineage longitudinal maturation monoclonal NAb neutralizing antibody P2C-1F11 lineage pathway reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibody sequence significantly viral infection [DOI] 10.1016/j.celrep.2022.111335 PMC 바로가기