Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2렘데시비르-이버멕틴 조합은 SARS-CoV-2에 대한 개선된 시험관 내 활성과 상승적인 상호작용을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: International journal of antimicrobial agents [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral activity approved Combination combination therapy combination treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CPE Cytopathic activity demonstrated drug Drug administration drug resistance effective Efficacy food greater in vitro in vitro activity in vivo Interaction Ivermectin management mechanism offer reduce Remdesivir reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support synergistic synergistic action synergy therapeutic therapeutic index to define Treatment strategies US Food and Drug Administration [DOI] 10.1016/j.ijantimicag.2022.106542 PMC 바로가기 [Article Type] Article
Reduction of Cell Fusion by Deletion in the Hypervariable Region of the Spike Protein of Mouse Hepatitis VirusArticle Published on 2022-02-152022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Brain Cell fusion cells Characteristics characterized CPE CPEs cultured cells DBT Deletion Effect explain expression level fusion greater growth highlighting hypervariable region in viral involved luciferase activity MHV mouse mouse hepatitis virus Pathogenesis produced reduction Region several variant significantly higher spike gene strain Strains the Spike the spike protein virus growth [DOI] 10.3390/v14020398 PMC 바로가기 [Article Type] Article
In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 ActivityBrief Report Published on 2022-02-142022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] activity acute respiratory syndrome Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity anti-SARS-CoV-2 agent Antiviral effect binding binding affinity camostat contribute coronavirus covalent bond COVID-19 CPE Cytopathic effect derivative derivatives element expected greater inhibition interact investigated molecular nafamostat predicted reported SARS-CoV-2 shown significantly synthesis TMPRSS2 TMPRSS2 inhibitor transmembrane serine protease unique weakened [DOI] 10.3390/v14020389 PMC 바로가기 [Article Type] Brief Report
The Petasites hybridus CO 2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In VitroArticle Published on 2022-01-072022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Petasites hybridus affecting Anti-COVID-19 Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug block caused clinical study compounds coronavirus disease COVID-19 CPE cytotoxicity deaths Delta delta variant Effect effective Extract FIVE in vitro inhibited isopetasin Novel coronavirus Petasite ranged reduction Remdesivir reported resulting SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication selectivity index significantly Spread tested therapeutic option treat variant variants Vero E6 cell viral output virus virus replication virus variants was used Wuhan Ze339 [DOI] 10.3390/v14010106 PMC 바로가기 [Article Type] Article
Exploration of SARS-CoV-2 3CL pro Inhibitors by Virtual Screening Methods, FRET Detection, and CPE Assay가상 스크리닝 방법, FRET 감지 및 CPE 분석에 의한 SARS-CoV-2 3CL pro 억제제 탐색Article Published on 2021-12-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료기술, 치료제, [키워드] 3CL pro Algorithm Analysis Antiviral effect Bayesian binding mechanism biological activity caused CDOCKER component Compound compounds coronavirus COVID-19 CPE cross Cytopathic effect database detection determined by drugs eight energy transfer exploration half-maximal inhibitory concentration indicated information inhibiting inhibitor machine learning algorithm Machine learning algorithms machine learning model molecular naïve Novel coronavirus predicted protease Replication SARS-CoV-2 Screening scutellarein selected trihydroxyflavone two-dimensional was determined [DOI] 10.1021/acs.jcim.1c01089 PMC 바로가기 [Article Type] Article
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy시험 관내 항 바이러스 활성 및 면역 조절 효과를 갖는 시스 티민은 COVID-19 요법에 대한 용도의 약물 후보가 될 가능성이있다.Article Published on 2021-12-242022-08-31 Journal: Cells [Category] SARS, 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory effect Antiviral antiviral action Antiviral effect antiviral effects applied assays Bacteria blood sample Blood samples calu-3 cells candidate caused coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients COVID-19 therapy CPE cystamine cysteamine Cytopathic effect cytopathic effects decrease demonstrated determine Disulfide drug Drug repurposing Effect IFN-γ immune response immunomodulatory effects in vitro independent independent of investigated modulate Oxidation pandemic parasites Potential repurposing respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly the SARS-CoV-2 therapy for COVID-19 these compound these compounds Treatment Vero E6 VERO E6 cells Viral viruses [DOI] 10.3390/cells11010052 PMC 바로가기 [Article Type] Article
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples감염성 예측: 임상 샘플에서 배양 가능한 SARS-CoV-2를 검출하기 위한 4가지 PCR 기반 분석 비교Article Published on 2021-12-132022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition analytical sensitivity caused Cell cell type clinical clinical sample clinical samples correlated COVID‐19 CPE Culture Cutoff Cytopathic effect dependent on detect diagnostic diagnostic testing effective expressing faster Genome identify infected individuals infectious Infectious virus Isolation Live virus Methods & Resources Microbiology, Virology & Host Pathogen Interaction negative‐strand pandemic parental predict replicative RNA RT‐PCR RT–PCR SARS‐CoV‐2 SARS‐CoV‐2 sgRNA significantly specimen subgenomic subset tested the cell TMRPSS2 transcriptional transcripts Vero E6 Vero E6 cell VERO E6 cells Viral Viral RNA viral RNA species viral RNA specy virus [DOI] 10.15252/emmm.202115290 PMC 바로가기 [Article Type] Article
Metabolomics Diagnosis of COVID-19 from Exhaled Breath CondensateArticle Published on 2021-12-062022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] acute lung injury acute respiratory syndrome Analysis approach biochemical biofluid Biomarkers breath Breath analysis can be used Cardiopulmonary caused change condensate coronavirus COVID-19 COVID-19 disease COVID-19 patient CPE demonstrated diagnostic edema Fatty acid GCxGC-MS healthy subject identify Infection metabolomics noninvasive analysis noninvasive diagnosis Patient performed Potential biomarker protective effect reliability respiratory tract SARS-CoV-2 SARS-COV-2 infection [DOI] 10.3390/metabo11120847 PMC 바로가기 [Article Type] Article
Fecal Carriage and Molecular Characterization of Carbapenemase-Producing Enterobacterales in the Pediatric Population in QatarResearch Article Published on 2021-11-102022-10-30 Journal: Microbiology Spectrum [Category] Coronavirus, MERS, SARS, [키워드] Klebsiella pneumoniae Arabian Peninsula Asymptomatic carrier Carbapenemase Care carriage carrier Characteristics characterization characterized children Comorbidity coronavirus disease country CPE dominant E. coli Endemic enzyme Escherichia coli exhibited expressed fecal Genes genetic diversity Genotype Health hospital implementation incidence International introduced isolate Klebsiella pneumoniae knowledge Local molecular Multiple NDM OXA-48 Patient patients pediatric pneumoniae Population produced rectal sequence Sequencing strain swab sample Travel variant was used whole-genome sequencing [DOI] 10.1128/Spectrum.01122-21 PMC 바로가기 [Article Type] Research Article
Cell-based Culture Informs Infectivity and Safe De-Isolation Assessments in Patients with Coronavirus Disease 2019세포 기반 배양으로 코로나바이러스 질병 2019 환자의 감염성 및 안전한 분리 제거 평가 정보 제공Article Published on 2021-11-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assessment Cell Chain Reaction collected coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 CPE Culture culture supernatant cycle threshold Cytopathic effect De-isolation defined ICU patient ICU Patients indicate Infection infection control infective Infectivity Inpatient Inpatients intensive care intensive care unit Isolation marker outpatients Patient patients PCR PCR-positive polymerase chain polymerase chain reaction positive protocols RNA SARS-CoV-2 SARS-CoV-2 PCR severe acute respiratory syndrome Coronavirus shedding significantly more symptom onset tested upper respiratory tract Vero viral culture virions virus replication was performed [DOI] 10.1093/cid/ciaa1579 PMC 바로가기 [Article Type] Article