Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine CandidatesArticle Published on 2022-09-132022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect Amino acid association candidate cellular immunity change changed composed coronavirus COVID-19 creating Delta Epidemic immune immune responses immunized mice Inactivated vaccine Inactivated Vaccines induce induced metabolic metabolism metabolomic metabolomics mice neutralizing antibody positive profile Protein proteomic proteomics response resulting SARS-CoV-2 Vaccine vaccine candidates Vaccine design Vaccines variant variants Variation virus [DOI] 10.3390/ijms231810644 PMC 바로가기
A Critical Analysis of the Use of Cilgavimab plus Tixagevimab Monoclonal Antibody Cocktail (Evusheld™) for COVID-19 Prophylaxis and TreatmentArticle Published on 2022-09-092022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] Alpha VOC Analysis antibody approved AZD7442 baseline cilgavimab Clinical data Clinical efficacy cocktail Combination conducted control arm convalescent plasma COVID-19 creating Delta VOC dominant early treatment Efficacy Evidence Evusheld Fc fragment high risk Immune escape Immunocompromised Immunocompromised patient Immunoglobulin indicated ingredient LAAB mAb monoclonal antibody monotherapy omicron Patient Prophylaxis Randomized controlled trial Regulatory robust subject subjects suggested the SARS-CoV-2 therapeutic Therapies Tixagevimab Treatment Trial trials variant viral loads VoC [DOI] 10.3390/v14091999 PMC 바로가기
Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemicRandomized Controlled Trial Published on 2022-09-022022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] active site activity affected applied approaches assessment assessments Canada CONSORT COVID-19 pandemic creating Critical Critical care Critical illness Cycling data entry determine discharge Endpoint enrolled extremity Guidance ICU ICUs In-hospital intensive care unit International Intervention Lower management Modification outcomes pandemic Patient Patient care physical Primary outcome Primary outcomes protocol provide Randomized Randomized controlled trial Randomized controlled trials randomized trial RCT receiving recruitment rehabilitation required Research Research design Research personnel Research report. retained risk strength Trial [DOI] 10.1186/s13063-022-06640-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Strategic purchasing and health systems resilience: Lessons from COVID-19 in selected European countriesReview article Published on 2022-09-012022-10-05 Journal: Health policy (Amsterdam, Netherlands) [Category] 신약개발, [키워드] conducted Contracting contributed country COVID-19 COVID-19 pandemic creating defined Efficiency European European country European health systems Features Government health system health systems Health systems resilience lesson pandemic Payers Purchasing Research respond selected Seven [DOI] 10.1016/j.healthpol.2022.06.005 [Article Type] Review article
COVID-19 vaccination simulating lymph node progression in a patient with prostate cancerCase report Published on 2022-09-012022-10-05 Journal: Radiology Case Reports [Category] 진단, [키워드] cancer patient choline Complete COVID-19 COVID-19 vaccination COVID-19 vaccine creating described diagnosed diagnostic displaying emission Evidence False-positive highlight Inflammatory involved less Lymph node lymph nodes male mRNA Patient PET-CT PET/CT Pfizer Positron progression Prostate Prostate cancer Radiotherapy regions second dose the patient treated vaccination [DOI] 10.1016/j.radcr.2022.05.072 [Article Type] Case report
Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 ProteaseArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, 치료기술, [키워드] 229E Activation acute respiratory syndrome affected airway being benefit Calu-3 cell change changes in cleavage conserved coronavirus creating Critical Delta dibasic experiment favor functional fusion peptide had no help host cell human coronavirus 229E humans immune evasion immunogenic Impact influence less MERS-CoV Middle East motif mutant Mutation mutations new SARS-CoV-2 no difference omicron pathogenic protease Proteases Protein pseudovirus pseudovirus entry reduced remained residue residues respiratory syndrome coronavirus reverse effect SARS-CoV-2 SARS-CoV-2 spike sequence shown spike spike functioning Spike protein Surveillance the SARS-CoV-2 TMPRSS13 TMPRSS13 protease TMPRSS2 Tolerance variant variants Variation virus entry Wuhan-Hu-1 [DOI] 10.1128/mbio.01376-22 PMC 바로가기
Nanotechnology-based strategies against SARS-CoV-2 variants Reviews Published on 2022-08-182022-10-05 Journal: Nature nanotechnology [Category] COVID19(2023년), SARS, 변종, 신약개발, 임상, 치료제, [키워드] acute respiratory syndrome coronavirus coronavirus disease COVID-19 creating effective Efficacy immunological Infectious disease Messenger RNA mRNA vaccine Nanotechnology pandemic SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants the SARS-CoV-2 Vaccine variant variants [DOI] 10.1038/s41565-022-01174-5 [Article Type] Reviews
Improving child health through Big Data and data science Reviews Published on 2022-08-162022-10-05 Journal: Pediatric Research [Category] 바이오마커, [키워드] assessments Characteristics child health childhood children complex creating defined determinant developmental dimension disease risk Diseases fetal for inclusion Genetic Health highlight identify Impact IMPROVE Improving infancy Interaction mechanisms outcomes Patient pediatric phenotype Predictive provide Racial recommendation reducing Regulatory Research resource susceptibility the United State Therapies Trajectories while [DOI] 10.1038/s41390-022-02264-9 [Article Type] Reviews
Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2Article Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant variant of concern (VOC) variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC [DOI] 10.3389/fimmu.2022.948431 PMC 바로가기
SARS-CoV-2 pre-exposure prophylaxis: A potential COVID-19 preventive strategy for high-risk populations, including healthcare workers, immunodeficient individuals, and poor vaccine respondersSARS-CoV-2 노출 전 예방: 의료 종사자, 면역 결핍 개인, 백신 반응 불량자를 포함한 고위험 인구를 위한 잠재적인 COVID-19 예방 전략Review Published on 2022-08-082022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, 치료제, [키워드] addition administration anti-SARS-CoV-2 Antibody titer Antiviral antiviral drugs benefit building complementary contributing to COVID-19 COVID-19 patient COVID-19 vaccine COVID-19 vaccines creating drug drug combination drugs effective framework Health care health care systems healthcare Healthcare workers high-risk population HIV HIV disease individuals Infection knowledge limit molnupiravir new virus Nirmatrelvir outcomes pandemic Paxlovid populations pre-exposure prophylaxis (PrEP) PrEP Prevent progression Prophylaxis Protective Protective antibody Remdesivir Responder responders restrict risk factor Risk factors Ritonavir SARS-CoV-2 SARS-COV-2 infection secondary to severe COVID-19 severity shown Spread suppressed Transmission uninfected Vaccine variants widespread [DOI] 10.3389/fpubh.2022.945448 PMC 바로가기 [Article Type] Review