Crystallography – Page 2 – Communicable Diseases Research

Structural diversity of the SARS-CoV-2 Omicron spike

SARS-CoV-2 오미크론 스파이크의 구조적 다양성

Article

Published on 2022-06-022022-09-11
Journal: Molecular Cell [Category] COVID19(2023년), SARS, 변종,

[키워드] affecting Analysis changes in communication conformational conformational change Critical cryo Cryo-electron microscopy cryo-EM structure cryo-EM structures Crystallography Delta delta variant determine domain dominant electron microscopy epitope fusion peptide immune immune evasion Impact interprotomer communication intraprotomer communication Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron spike peptide RBD Receptor-binding domain SARS-CoV-2 evolution spike Spike protein the SARS-CoV-2 Transmissibility variant vector analysis. virus transmissibility X-ray X-ray crystallography
[DOI] 10.1016/j.molcel.2022.03.028 PMC 바로가기 [Article Type] Article

A Structural Comparison of SARS-CoV-2 Main Protease and Animal Coronaviral Main Protease Reveals Species-Specific Ligand Binding and Dimerization Mechanism

Article

Published on 2022-05-182023-07-09
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년),

[키워드] coronavirus Coronavirus pandemic COVID-19 Crystallography Protein conformation SARS-CoV-2 viral proteases X-ray
[DOI] 10.3390/ijms23105669 PMC 바로가기

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking

SARS-CoV-2 스파이크의 확장된 모티프는 역행 인신매매에서 숙주 코토머의 결합 및 방출을 조절합니다

Article

Published on 2022-02-082022-09-10
Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 변종,

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성

Research Paper

Published on 2022-01-012022-09-01
Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] In vitro and in vivo function abrogated ACE2 Analysis anti-RBD Anti-RBD antibody anti-receptor-binding domain antibodies antibody antibody cocktail Antibody-antigen complex attenuate B.1.1.7 B.1.351 B.1.617.2 binding cocktail convalescent patient Convalescent patients COVID-19 Cryo-electron microscopy Crystallography curtail dissect effective Efficacy electron microscopy epitope Epitopes evaluate feature Formulation hamster hamsters Hospitalization Human monoclonal antibody in vitro in vivo Infection leads lung viral load mechanism mechanism of action monoclonal antibodies monoclonal antibody Mutation neutralization Neutralizing neutralizing monoclonal antibodies non-overlapping epitope non-overlapping epitopes patients with SARS-CoV-2 Prevent Prophylactic pulmonary inflammation RBD Receptor-binding domain epitope reduce reported residue reveal SARS-CoV-2 SARS-COV-2 infection shown somatic mutations Structural analysis Structure structure-function subsequent Support the RBD therapeutic therapeutic potential unique variable region variant variants variants of concern Viral viral RBD viral shedding virus weight loss wild type
[DOI] 10.7150/thno.65563 PMC 바로가기 [Article Type] Research Paper

Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses

박쥐와 인간 코로나바이러스 ORF8 단백질 Ig-유사 도메인의 결정 구조는 면역 반응의 다양성에 대한 통찰력을 제공합니다

Immunology

Published on 2021-12-172022-09-11
Journal: Frontiers in Immunology [Category] 바이오마커, 변종,

[키워드] accessory protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assays bat biochemical biological function Biological functions CD14 Characteristics Combined conditions conformations coronavirus COVID-19 crystal crystal structure crystal structures Crystallography Disulfide Diversity domain Effect human coronavirus human peripheral blood immune immune responses in vitro insight Interaction interfere isoforms monocyte Monocytes Mutagenesis ORF8 ORF8 protein ORF8 proteins Peripheral blood Protein RaTG13 residue respiratory response responsible RNA genome SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure subsequent the epidemic variant Viral
[DOI] 10.3389/fimmu.2021.807134 PMC 바로가기 [Article Type] Immunology

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

Research article

Published on 2021-10-012022-10-05
Journal: European journal of medicinal chemistry [Category] SARS, 치료제,

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

Article

Published on 2021-09-252023-06-14
Journal: Cell Reports [Category] MERS, SARS,

[키워드] anti-viral therapeutics cryo-EM Crystallography human antibodies mAb SARS-CoV-2
[DOI] 10.1016/j.celrep.2021.109822 PMC 바로가기 [Article Type] Article

Protein purification and crystallization of HLA-A∗02:01 in complex with SARS-CoV-2 peptides

SARS-CoV-2 펩타이드와의 복합체에서 HLA-A*02:01의 단백질 정제 및 결정화

Article

Published on 2021-09-172022-09-11
Journal: STAR protocols [Category] SARS, 치료법,

Structures of synthetic nanobody–SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction

Research Article

Published on 2021-09-162022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] accompanied ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody BSA, buried surface area CCs, correlation coefficients CDR1, complementarity-determining region 1 CDR2, complementarity-determining region 2 CDR3, complementarity-determining region 3 complementarity-determining region complexes conformational coronavirus cryo-EM cryo-EM structure crystal structure Crystallography CTF, contrast transfer function difference domain enzyme explained FIVE indicate interact Interaction PDB, Protein Data Bank RBD RBD variant RBD, receptor-binding domain S-6P, HexaPro S S, spike SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography single-domain antibody (sdAb, nanobody) Spike protein SPR, surface plasmon resonance Spread Structure structures surface plasmon resonance (SPR) sybody synthetic nanobodies the RBD the SARS-CoV-2 Trimeric spike protein unliganded variant X-ray
[DOI] 10.1016/j.jbc.2021.101202 PMC 바로가기 [Article Type] Research Article

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication

SARS-COV-2 복제에서 NSP7, NSP8 및 NSP12의 과도 및 안정화 된 복합체

Articles

Published on 2021-08-032022-09-10
Journal: Biophysical Journal [Category] MERS, SARS, 유전자 메커니즘,

[키워드] activities addition amplify atomic Combination complex complexation complexes component components conducted conformation Coordinate crystal structure crystal structures Crystallography defined Disruption DNA form functions greater high-resolution crystal structure Host host immune responses immune responses Interaction make up mechanism mRNA new virus Nsp12 Nsp7 NSP8 Propagation Protein Proteins recognizing Replication reported responsible RNA RNA-dependent RNA polymerase RTC SANS SARS-CoV-2 SARS-CoV-2 replication SAXS scattering size exclusion chromatography Structure Transcription Transient viability Viral Viral proteins Viral RNA virus
[DOI] 10.1016/j.bpj.2021.06.006 PMC 바로가기 [Article Type] Articles