A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M pro ) of SARS-CoV-2 and MERS-CoVarticle Published on 2024-07-302024-09-05 Journal: JACS Au [Category] update2024, [키워드] 3CL Protease antivirals COVID Crystallography ibuzatrelvir SARS-CoV-2 [DOI] 10.1021/jacsau.4c00508 PMC 바로가기 [Article Type] article
ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesteraseResearch Article Published on 2024-05-142024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] binding protein conformational change Crystallography DNA repair Genomics inhibition mechanism phosphodiesterase: cancer RNA Small Angle X-ray Scattering (SAXS) structural biology [DOI] 10.1016/j.jbc.2024.107368 PMC 바로가기 [Article Type] Research Article
Structural and functional comparisons of salivary α-glucosidases from the mosquito vectors Aedes aegypti , Anopheles gambiae , and Culex quinquefasciatusArticle Published on 2024-03-142024-09-05 Journal: Insect Biochemistry and Molecular Biology [Category] update2024, [키워드] arthropods Crystallography enzyme kinetics hematogaphy sugar vector-borne diseases [DOI] 10.1016/j.ibmb.2024.104097 PMC 바로가기 [Article Type] Article
Molecular basis of the final step of cell division in Streptococcus pneumoniae폐렴구균에서 세포 분열의 마지막 단계의 분자적 기초Article Published on 2023-07-252024-08-24 Journal: Cell Reports [Category] 폐렴구균 감염증, [키워드] bacterial division cell wall CP: Microbiology Crystallography LytB molecular dynamics peptidoglycan SAXS StkP Streptococcus pneumoniae teichoic acid.
Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunityArticle Published on 2023-07-192024-09-05 Journal: Cell Reports [Category] update2024, [키워드] Antigen presentation CD4+ T cells coronavirus COVID-19 Crystallography HLA class II Immune escape immune memory SARS-CoV-2 T cells [DOI] 10.1016/j.celrep.2023.112827 PMC 바로가기 [Article Type] Article
Structural studies of protein–nucleic acid complexes: A brief overview of the selected techniquesMini-Review Published on 2023-04-292024-09-05 Journal: Computational and Structural Biotechnology Journal [Category] update2024, [키워드] Atomic force microscopy (AFM) Circular Dichroism (DC) cryogenic electron microscopy (cryo-EM) Crystallography DNA-protein interactions Infrared Scpectroscopy (IR) nuclear magnetic resonance (NMR) Nucleic acid binding proteins Nucleoproteins Protein-nucleic acid complex RNA-protein interactions Small Angle Neutron Scattering (SANS) Small Angle X-ray Scattering (SAXS) [DOI] 10.1016/j.csbj.2023.04.028 PMC 바로가기 [Article Type] Mini-Review
Turning high-throughput structural biology into predictive inhibitor designPhysical Sciences Published on 2023-03-062024-09-05 Journal: Proceedings of the National Academy of Sciences of [Category] update2024, [키워드] Crystallography drug design machine learning [DOI] 10.1073/pnas.2214168120 PMC 바로가기 [Article Type] Physical Sciences
Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoesArticle Published on 2023-02-142024-08-27 Journal: Immunity [Category] 말라리아, [키워드] Crystallography human monoclonal antibodies malaria Pfs48/45 Plasmodium falciparum transmission-blocking vaccine transmission-reducing activity.
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease용도 변경에서 재설계까지: SARS-CoV-2 주요 프로테아제의 강력한 억제제에 대한 보세프레비르의 최적화Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3C-like protease activities activity addition alpha-ketoamides alphacoronavirus approach Betacoronavirus boceprevir complexes coronavirus COVID-19 coxsackievirus Coxsackievirus B3 crystal structure crystal structures Crystallography enterovirus enterovirus 3C protease exhibited Glutamine HCoV HCoV-NL63 hepatitis C hepatitis C virus inhibitor lactam M pro main protease moderate NL63 optimization potency potent protease Protease inhibitor Proteases replacing repurposing resulting SARS-CoV-2 starting structure-based design Structure-based drug design telaprevir telaprevir. the SARS-CoV-2 treatments for COVID-19 Validity virus X-ray X-ray crystallography [DOI] 10.3390/molecules27134292 PMC 바로가기 [Article Type] Article
Potent cross-reactive antibodies following Omicron breakthrough in vaccineesArticle Published on 2022-06-092023-07-09 Journal: Cell [Category] COVID19(2023년), [키워드] Antibody responses BA.1 BA.1.1 BA.2 COVID-19 Crystallography Immune escape neutralization omicron Receptor binding domain SARS-CoV-2 variants of concern [DOI] 10.1016/j.cell.2022.05.014 PMC 바로가기