The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus MonkeysGenetics Published on 2021-01-182022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Analysis analyzed animal model association Brain BSG children coronavirus coronavirus 2 coronavirus disease correlated COVID-19 CTSB CTSL development developmental differential expression DPP4 dynamic endosomal protease evaluate exhibited expressed expression expression level feature help highest Immune cell infiltration Immunity incidence Infection livers lung Lungs mediator Mild moderate Monkey Neonate Neonates Other pandemic pathogenic Population populations Potential protease Protective reached receptor researcher respiratory Rhesus monkey SARS-CoV-2 SARS-CoV-2 receptor severe disease Spread stages susceptibility therapeutic strategy TMPRSS2 TMPRSS9 Transcriptome transmembrane serine protease TTSPs Type Variability [DOI] 10.3389/fgene.2020.607479 PMC 바로가기 [Article Type] Genetics
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complicationsCOVID-19 임상 합병증을 표적으로 하는 SARS-CoV-2 수명 주기, 병태생리학 및 합리화된 치료에 대한 통찰력Review Published on 2021-01-122022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, MERS, [키워드] “cytokine storm” ACE2 activate Adaptive immune response adverse effect adverse effects approach approaches ARDS AT1R clinical complication collateral tissue damage complications of COVID-19 COVID-19 CTSB Cytokine storm distress expression gastrointestinal tract Host human gene hyper-cytokinemia immune responses Infection infection rate infection rates Inflammation inflammatory immune response insight life cycle life-threatening mitigate multi-organ collapse organotropism of SARS-CoV-2 pathobiology of COVID-19 Pathologies pathophysiology Phase 1 Phase 2 Propagation respiratory respiratory and gastrointestinal tract respiratory distress Respiratory distress syndrome robust SARS-CoV-2 SARS-CoV-2 life cycle Sex Signaling Support suppress syndrome systemic failure tissue tissue damage tissues TMPRSS2 Treatment Trigger triggered triggers two-phase disease Viral viral infection virus virus antigen presentation virus transmission [DOI] 10.1186/s12929-020-00703-5 PMC 바로가기 [Article Type] Review
Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytesSARS-CoV-2 진입 매개체는 심근세포가 우선적으로 풍부합니다.Research Published on 2021-01-042022-09-10 Journal: Hereditas [Category] 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding cardiac conduction cardiac injury cardiac muscle cathepsin B cathepsin L Cell cellular coronavirus disease Coronavirus disease 2019 cough COVID-19 CTSB CTSL DEGs differentially expressed gene Differentially expressed genes embryonic enrichment analysis expression Fever Injury ion channel less mechanism mediator mitochondrial muscle contraction Patient patients with COVID-19 priming protease Regulation respiratory respiratory chain respiratory symptom respiratory symptoms Result RNA expression S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2, COVID-19, ACE2, CTSB, CTSL, cardiac injury Serine serine protease Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Signaling single-cell Spread susceptible TMPRSS2 transmembrane serine protease ventricular Viral viral transcription [DOI] 10.1186/s41065-020-00168-4 PMC 바로가기 [Article Type] Research
Female reproductive tract has low concentration of SARS-CoV2 receptors여성 생식기는 SARS-CoV2 수용체 농도가 낮습니다.Research Article Published on 2020-12-142022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] ACE2 Breast cathepsin cathepsin B cathepsin L cell type cell types co-expression Concentration Cornea CTSB CTSL dataset detect explain expression facilitate fallopian tube female reproductive organ female reproductive organs host cell Infection investigated myometrium nasal epithelium outcome pandemic Prevalence Proteases recent receptor receptors reproductive reproductive organs SARS-CoV2 SARS2 Sequencing single-cell susceptible the cell tissue TMPRSS2 Transmission unlikely uterus [DOI] 10.1371/journal.pone.0243959 PMC 바로가기 [Article Type] Research Article
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer범암에서 CTSL/B 및 SARS-CoV-2 수용체 ACE2의 게놈, 후성유전체 및 면역 아형 분석Research Paper Published on 2020-11-302022-09-10 Journal: Aging (Albany NY) [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 addition Analysis analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 association bioinformatics Cancer cathepsin cathepsin B cathepsin L Cell Cervical copy number COVID-19 CTSB CTSL CTSL/B Cystadenocarcinoma demonstrated DNA methylation endocervical enzyme epigenomic Gene Expression genetic alterations healthcare IFN-gamma immune International Methylation negative correlation ovarian overexpressed positive correlation potential risk present Prognosis protease receptor Result risk risk factor RNA expression SARS-coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serous Cystadenocarcinoma Society Squamous cell Squamous cell carcinoma stomach subtype upregulation urothelial carcinoma [DOI] 10.18632/aging.104147 PMC 바로가기 [Article Type] Research Paper
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approachResearch article Published on 2020-11-012022-10-05 Journal: Toxicology and applied pharmacology [Category] SARS, 치료법, [키워드] affected Anti-COVID-19 Therapy antibiotic antiretroviral drugs apoA1 approach Autoimmune diseases Azithromycin BCL2L1 benefit candidate drug CCL2 Chloroquine chloroquine/hydroxychloroquine clinical condition Combination Comparative COVID-19 CTSB CXCL8 CYP3A4 Cytoscape software demonstrated Diseases disorders downregulated drug drug combination dyslipidaemia expected expression greater ICAM1 IL1B IL6 immune response improvement in silico in silico Approach infected patient Inflammation involved lipid metabolism Lopinavir Patient pharmacological problems Research risk Ritonavir Safety SARS-CoV-2 therapy TNF Toxicogenomics Treatment was used [DOI] 10.1016/j.taap.2020.115237 [Article Type] Research article
Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2Cell and Developmental Biology Published on 2020-08-192022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] abundantly expressed ACE2 addition ANPEP binding carried Cell cells cellular co-expressed Complication component coronavirus Coronaviruses COVID-19 CTSB CTSL DPP4 during pregnancy Express expressed Factor Glucose healthy host cells Human identify in viral infected with SARS-CoV-2 Infection Inflammation involved JAK-STAT pathway marker membranes mitochondrial metabolism mother mRNA Neonate novel coronavirus disease Other other protease pathogen pathway physically Placenta placental positive predict Pregnancy pregnant women Premature priming proportion protease TMPRSS2 Proteases PROTECT Protein receptor receptor ACE2 receptors Replication required respiratory RNA-Seq rupture SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown single-cell RNA-seq subset subtype systematic review target the S protein these cell TMPRSS2 Transport trophoblast unique viral S protein Viremia virus were also expressed with COVID-19 [DOI] 10.3389/fcell.2020.00783 PMC 바로가기 [Article Type] Cell and Developmental Biology