Exploring Toxins for Hunting SARS-CoV-2 Main Protease Inhibitors: Molecular Docking, Molecular Dynamics, Pharmacokinetic Properties, and Reactome StudyArticle Published on 2022-01-272022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Analysis binding affinity binding energy biochemical characterized Combination conducted COVID-19 patient CTSB CTSK CTSL database Dynamics enzyme hunting IL-13 IL-4 in silico in silico screening include inhibitor Ligand M pro matrix metalloproteinase MD simulations molecular molecular docking molecular docking calculations molecular dynamics (MD) simulations Pathway enrichment analysis Prevent protease provide Reactome SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication screened severe lung injury Signaling toxin toxins [DOI] 10.3390/ph15020153 PMC 바로가기 [Article Type] Article
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer PatientsBioengineering and Biotechnology Published on 2022-01-262022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] acute respiratory syndrome bioinformatic analysis Cancer cancer patient cancer tissue cathepsin cell lines Comprehensive coronavirus correlated correlation CTSB CTSL death digestive distribution expressed expression facilitate Gallbladder Genetic host cells Immune cell infiltration immune infiltration in healthy individual individual infect investigated kidney tissue liver Lungs novel overexpressed Prognosis Prognostic value protease Proteases reported SARS-CoV-2 SARS-COV-2 infection significantly suggested susceptible tissues translational [DOI] 10.3389/fbioe.2022.780751 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks흡연자에서 COVID-19의 불리한 임상 결과는 H3K4me3, H3K9me3 및 H3K27me3 히스톤 마크에 의해 매개됩니다Review Published on 2022-01-132022-09-11 Journal: Epigenomics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Abstract ACE2 Alter AT1R Clinical outcome COVID-19 CTSD CTSL deleterious effect Epigenetic epigenetic gene regulation epigenetics and disease Evidence expression favor H3K27me3 H3K4me3 HeK9me3 histone histone modifications IL-6 implicated indicate individual induce mdig mechanisms mediator modifications NRP1 NRP2 PGE2 proportion Protein recent receptor receptors regulate respiratory Respiratory disease respiratory diseases SARS-CoV-2 SARS-CoV-2 entry severe COVID-19 SLC6A20 smoker smoking Transcription turn upregulating Viral viral entry [DOI] 10.2217/epi-2021-0476 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and Implantation Window: Gene Expression Mapping of Human Endometrium and Preimplantation EmbryoReview Published on 2021-12-102022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] ACE2 ACE2 pathway Affymetrix analyzed ART biopsy BSG candidate Cohort CTSA CTSL detectable Embryo endometrial receptivity endometrium entire cohort examined expression level female genital tract gene expression level gene expression profile Human implantation infect cell knowledge mapping Microarray ovarian performed potential risk preimplantation embryos Prevalence protease protocol question receptor renin-angiotensin system reported risk SARS-CoV-2 SARS-COV-2 infection stimulated target tissue transfer understanding virus infection [DOI] 10.3390/life11121378 PMC 바로가기 [Article Type] Review
Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta CellsMolecular Biosciences Published on 2021-11-082022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 analyzed canonical Cell cell entry cells changes in coronavirus COVID-19 COVID-19 pandemic CTSL DAAM1 demonstrated DPP4 expressed expression host protein Human identify Infection Interaction mechanism Microarray PAICS Placenta placental predicted prediction Pregnancy Protein Proteins receptor Replication route SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection single-cell These cells TMPRSS2 transcriptional translated transmission of SARS-CoV-2 virus virus entry mediator Zika virus [DOI] 10.3389/fmolb.2021.614728 PMC 바로가기 [Article Type] Molecular Biosciences
Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adultsOriginal Article Published on 2021-10-222022-10-30 Journal: Journal of Physiological Anthropology [Category] COVID-19, [키워드] activated Alter Analysis cathepsin L changed Cold stress condition Coronavirus disease-19 CTSL Differential gene expression differentially expressed differentially expressed gene enrichment analysis experiment expression level FDR Fold change Human humans initial Invasion investigated Japanese key factor Local log male Mild molecular mechanism Novel coronavirus Ontology Protein recent responsible Result RNA sequencing RNA-Seq Saliva saliva sample SARS-CoV-2 Sequencing significantly Stress subject suggested supplementary material susceptibility temperature Thermoregulation transcriptional transcriptional change transcriptional profile upregulated were used [DOI] 10.1186/s40101-021-00267-9 PMC 바로가기 [Article Type] Original Article
Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestationsResearch article Published on 2021-09-292022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] age Analysis binding binding ability Brain cathepsin Cathepsins complexes COVID-19 COVID-19 infection CTSL cyclosporine disorder disorders drug Drug repurposing expression Health host cells Hypothesis identify involved lysosomal cathepsins mitigate molecular molecular docking Neurological disorders neurological manifestation neurological manifestations performed potential therapeutic target Proteases required SARS-CoV-2 SARS-CoV-2 entry shown stability targeting virus entry [DOI] 10.1016/j.heliyon.2021.e08089 [Article Type] Research article
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium선입견 인간 자궁 내막에서 SARS-CoV-2 세포 진입 인자의 단일 세포 RNA 시퀀싱Article Published on 2021-09-182022-09-11 Journal: Human reproduction (Oxford, England) [Category] SARS, 치료기술, [키워드] ACE2 Analysis ANPEP Asymptomatic COVID-19 Biohub biopsy board BSG canonical carriers caution CD209 Cell cell entry cell type cells chance CLEC4G Cohort conducted COVID-19 CTSB CTSL dataset Donor during pregnancy early pregnancy Efficiency epithelial cell epithelial cells European examined expressed expression expression of gene Factor Focusing framework furin Gene Expression Gene Expression Omnibus head healthy Horizon IFITM1 implication Infection Innovation luminal LY6E menstrual menstrual cycle Miguel NCBI NRP1 offer Pregnancy processed Program proliferative Proteases protein expression raw data receptor receptor ACE2 reported reproductive resource reveal risk risk of infection RNA sequencing SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 receptor scRNAseq Sequence Read Archive single-cell level Single-cell RNA-sequencing Spanish Stanford stromal cells supported the SARS-CoV-2 tissue TMPRSS11A TMPRSS2 TMPRSS4 transcriptomics transmission of SARS-CoV-2 Type union vertical transmission viral infection virus [DOI] 10.1093/humrep/deab183 PMC 바로가기 [Article Type] Article
Management of Patients With Glucocorticoid-Related Diseases and COVID-19글루코코르티코이드 관련 질환 및 COVID-19 환자 관리Review Published on 2021-09-142022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration Adrenal insufficiency adrenocortical carcinoma affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anticancer binding Cancer caused circulating cleaved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTSB CTSL Cushing’s syndrome cushing’s syndrome cytokine Cytokine storm Endocrine enzyme expressed furin gastrointestinal tract genes encoding glucocorticoid Glucocorticoids group Health Health crisis host cell host cells hyperaldosteronism immune response Immunosuppressant immunosuppressants immunosuppressive in silico analysis Infection inhibitory effect kidney lung management mRNA expression outcome pandemic pathophysiological mechanism Patient Pituitary protease respiratory SARS-CoV-2 secreted Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility the cytokine storm the timing tissues TMPRSS2 transmembrane transmembrane protease serine 2 Tumor tumors [DOI] 10.3389/fendo.2021.705214 PMC 바로가기 [Article Type] Review
Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/LResearch Article Published on 2021-08-182022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] activate analyzed cathepsin Combination Compound COVID-19 CTSL cysteine proteases drug drug combination Effect enrichment analysis entry pathway expression gene expression signature gene-gene interaction Genes GSEA host cells host protease human proteins identify interact molecular docking analysis performed potential treatment option Proteases regulatory element SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 proteins serine protease target the spike protein Therapeutic benefit therapy TMPRSS2 transmembrane serine protease upstream [DOI] 10.1371/journal.pone.0256141 PMC 바로가기 [Article Type] Research Article